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Share your dilemmas and get honest opinions from other Mumsnetters.

To be scared of taking estrogel?

7 replies

Nearly40mumof4 · 13/02/2026 10:43

Posted recently re my trouble getting treatment for pmdd and peri menopause symptoms. Got the prescription for sylnd pill and estrogel and was ready to start 3 days ago. Then suddenly got nervous about using estrogen — increased risk of cancer and also worries about cross contamination if of my children /dh touches where I’ve put it. Then went down rabbit hole of research papers about estrogen absorption / contamination and scared myself. I have taken the sylnd pill for 3 days and can already feel the impact on me. Would normally be feeling good on day 3/4 but now just feel flat and sad and no enthusiasm in anything. Even food has no appeal and normally I love cooking and eating.
Am I being crazy to worry about increased cancer risk if I start taking estrogel at 39? Am now thinking I was stupid to even get the prescription as “it’s not that bad” but I know it is that bad, I just have this magical ability to forget about the bad days when I’m in the first 12 days.
Does anyone relate? Should I stop being an idiot and just put the gel on!?

OP posts:
Farkinhell · 13/02/2026 10:45

Put the gel on. Follow the instructions. You'll be fine and you'll start to feel much better soon.

I speak from experience!

TofuTuesday · 13/02/2026 10:47

Re cross contamination I use it first thing on inner thighs or upper arms and just takes five mins to dry. I keep the bottle in a wall cabinet in the bathroom and sometimes rinse it if I’ve got the gel on it - I think this is over cautious!

BlimpyWimpy · 13/02/2026 10:50

Slynd and oestrogel combined have totally resolved my PMDD. I can’t have a break from either without a major crash. Oestrogel takes a while to build up but I feel like a different person.

just wash your hands etc and follow the instructions!

Winederlust · 13/02/2026 10:52

I have family history of breast cancer and still haven't hesitated in taking HRT. The increased risk is minimal and the difference it makes to my every day existence is immeasurable. I've been unable to take it for the last 3 weeks and it's hit me like a tonne of bricks. 3 days back on it and I'm already feeling a little more like myself.
It's a no-brainer for me.

PoppyFleur · 13/02/2026 11:00

I apply the oestrogel at night before bed, wash my hands thoroughly and then brush teeth, cleanse face and by then it’s all dry. Takes 5 minutes. There are risks to any medication but the positives out weigh the small risks.

Nearly40mumof4 · 13/02/2026 11:20

Ok thanks all, I knew I was being stupid and my health anxiety is speaking, not my rational mind! I will start the estrogel this evening. I think I got worried by looking at the effects on children and worrying me that I might shrink their nuts or put my little girl in to early puberty.
I would be so glad to have relief from the pmdd and I’m sure the benefits if that will outweigh the risk.

OP posts:
LuxuryWoman2020 · 13/02/2026 11:40

I love my gel, it has made such a difference to my energy, mood, no more hot flushes. It's been great for me

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