Meet the Other Phone. Child-safe in minutes.

Meet the Other Phone.
Child-safe in minutes.

Buy now

Please or to access all these features

AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

The rise of the trend of GLP-1 and the pressure it brings?

697 replies

PiriPiriMenopause · 18/12/2025 09:07

First of all I just want to say I have nothing against the choice people make for the injections at all, I think they’re great and they obviously work for people who need them! I totally get why someone would want to take it, and it really is transforming lives.

But I worry about the pressure this is bringing so the it. I’m a size 14 and pretty normal. At the moment I don’t have trouble buying clothes or getting stuff to fit. My BMI is about 26 which yes is higher than the recommended but not massively so.

So many people I know are on this drug! Honestly, in my normal every day life, I know of at least 15 people who are taking it. It’s working brilliantly and the results are fantastic they’re happy and it’s great, I love seeing how their confidence has turned on a sixpence. Some of the women were larger than me some were not that much larger than me or the same size.

I’m not sure if my experience is a reflection of what’s going on country wide or not. But AIBU to worry about the knock on effect this will have moving forward. I worry that a size 14 will soon become almost obsolete in the shops because people are no longer requiring larger sizes, I worry about the knock on pressure this will bring to those of us who can’t afford to take it or simply don’t want to or can’t take it. I worry about it becoming a culture for people of my daughter’s age and what it means for their confidence in future.

I’m just interested to see if I’m just being paranoid or if this is something other people worry about. There’s always been a massive pressure on women in particular with their size and appearance but this is the first time I’ve ever really felt it so extreme!

OP posts:
Eyeshadow · 18/12/2025 15:57

SilenceInside · 18/12/2025 15:53

@Eyeshadowive been on Mounjaro for 18 months and lost almost 11st. Of course I have made major lifestyle changes and plan to maintain them. When I started WLI I was aware that I would need to be on them for maybe 2 years or so to get to target weight and then I would have the challenge of maintaining. I am not stupid, and I am aware of how I got obese. I now have a tool, not a miracle cure, but a tool that is effective in helping me lose weight and to maintain that loss. I know I don’t ever have to be obese ever again. I can stop the WLI, and start again if I need to. Or not if I don’t. Whatever works.

Which is amazing!

But you have made a conscious effort to make a lifestyle change and so you’re not the type of person I am talking about.

ladyofshertonabbas · 18/12/2025 15:58

There is.no way size 14 will ever become obsolete.

SilenceInside · 18/12/2025 16:00

@Eyeshadow I think that most people are like me and are aware of the issues. And actually, even if they’re not, and are happy to continue taking medicaiton to control their weight, then that’s fine too. It’s also fine if they try without, and realise they need to start taking it again, or make some major changes, or both at the same time. All valid options, and dependent on personal circumstances.

lemonts · 18/12/2025 16:00

Eyeshadow · 18/12/2025 15:55

You don’t think people need to change their lifestyle in order to lose weight or maintain it?

You don’t think they need to change their mindset?

Of course you need to reprogram your brain.
You can’t go from being morbidly obese (a disease) your whole life, to a healthier weight and to maintain with absolutely no sort of lifestyle/mind changes.

This is the exact issue that I have with the injections.
I am in full support of the injections but it’s these sorts of mindsets that I am against.

Do you understand how the medications work? Do you understand that some people's brains don't give them the 'full' signal in the same way that other peoples do? Do you think that they can change that hormonal and chemical profile through willpower? If so, you are even more ill informed than I thought.

MargoLivebetter · 18/12/2025 16:01

@Eyeshadow what type of person are you talking about? I've been on the WLI threads since August 2024 and I don't know a single poster who hasn't had to change their food intake on WLI to lose weight!!!!

Dragonscaledaisy · 18/12/2025 16:02

Daisywhatsyouranswer · 18/12/2025 14:36

Surprised so many thinking long term effects unknown, can’t decide if it’s ignorance or wishful thinking to be honest.

the main agonist in these drugs was first discovered in the 1920s. It is simply a synthetic hormone we produce naturally.
it was then developed in the fifties.
it went through 15 years of trials before being approved for diabetics. Inc diabetics who got to a normal weight. That was over 20 years ago.
it was the trialled for weight loss, again, multiple years, that was approved about 3 years ago, I think by the fda first in the USA.
it was then approved by most health care regulators in countries with functioning health care systems.
this year the WHO concluded their research as they didn’t wish to comment earlier as they wished to examine all the long term impacts. They then recommended all countries with a functioning health care system make available for diabetes.
they then subsequently completed their research into long term effects for weight loss and recommended it was made available for obesity as a long term treatment and issued guidance for all countries to now look at affordability and availability, as they were concerned many people are unable to access due to cost and availability restrictions.
when the who puts a medication on its essential meds list, then countries meet the recommendation.
the drug is now in multiple new trials, all seperate, for multiple other uses
cancer reduction
cardio vascular health
kidney and liver health
dementia reduction
alcohol and drug abuse reduction
anti ageing, - not your face but trials have shown that due to the reduction of inflammation our cells are able to regenerate, meaning the scientists are now seeing, ageing either slow, stop or reverse. The fountain of youth is not about appearance, but what’s going on inside but of course if you are healthy inside you look healthy outside,

this is just a peptide, one we produce naturally, but which production of declines with age, or some people never produce enough off, the ability to get a medicine approved is now incredibly onerous, post thalidomide, and these drugs didn’t just do a 15 year initial trial, they have been in trials ever since. So nearly 40 years now.

The global health authorities know the safety of the drugs, they know the global uptake requirements.

me personally I’ve researched it, and I discussed with my gp before starting, who herself had been prescribing for over two decades and had very good results, albeit for diabetes, and actually said she wished she could prescribe. It’s a scandal about the cost for an essential medication, but this will resolve in time. I am staying on a low dose, as I know my body now works optimally, I am staying on primarily for the health benefits, reduced cancers, better cardio vascular , kidney and liver function, optimal blood sugar and insulin control, reduced risk of diabetes, the reduced inflammation, the improvement in my internal organs,

i recently had a full swathe of blood tests and every one came back in peak health, all smack bang in the middle of the healthy range, everything, from blood cell count to kidney, liver etc and my cholesterol is now low and very healthy.

so no, there won’t be any serious class action law suits, long term effects no one knew, they already know. And that’s why they all approved for life time usage.

lets be honest, the scaremongering is not as people think all the global health authorities have suddenly become inefficient, it’s because people are getting slim, or more accurately women are, and those who can’t access feel envy and or resentment.

The STEP trials of semaglutide in individuals with overweight or obesity weren't 15 years long - these were the pivotals used for approval. Which drugs are you talking about?
Edit: I see you're talking about a T2D population. That's a very different population though.

NikkiPotnick · 18/12/2025 16:07

lemonts · 18/12/2025 16:00

Do you understand how the medications work? Do you understand that some people's brains don't give them the 'full' signal in the same way that other peoples do? Do you think that they can change that hormonal and chemical profile through willpower? If so, you are even more ill informed than I thought.

If you think of this sort of a thing as a belief system it makes more sense.

Fornerly obese people must be able to maintain weight loss through diet advice, because I want that to be true. They can't stay on WLIs permanently, because I want that to be true.

Hohohohohohoho2025 · 18/12/2025 16:07

Grammarnut · 18/12/2025 15:47

Well, perhaps it's a good idea but being 'very thin' is also unhealthy. What one should remember is that what is now a size 14 was, in c.1973 something like a size 18 - 20. I have a jacket from said year which is a 12. It is tiny, with a fitted waist about 24 inches round. And size 12 was considered large in 1973!
We are overweight, and have been consistently lied to by a fashion industry which has increased sizes over time i.e. someone now a size 4-6 could probably
fit into a 50s size 12!
But losing weight by having GLP to reduce appetite isn't going to work because once off the drug appetite returns. The only reliable way is to change one's diet and keep to the new, weight losing diet permanently. Which requires self-discipline and making choices that do not coincide with what one always wants to do.

Edited

This show a lack of understanding of the scientific knowledge of obesity and how these drugs work. For obese people unleaa they take GLP their body will continue to produce excess hunger hormones until they reach their highest ever weight. This is why these drugs are considered to be drugs for life.

Eyeshadow · 18/12/2025 16:08

MargoLivebetter · 18/12/2025 15:52

@Eyeshadow it certainly didn't sound as though you were pro WLI when you were applauding those who put the effort in to lose weight without them and telling us that those who came off them and put the weight back on would "pay the price" whatever that means!

If only the NHS could offer everyone who was overweight really useful, helpful and individualised proper support - that would be absolutely amazing. How much do you think that would cost and when do you think that might be put in place?

Why would it sound like I wasn’t pro WLI when I said it should be available on the NHS so that people get support and poor people can take it too??

I said it would still be cheaper than then the issues caused by obesity.

But because I’m not saying it’s a miracle cure then posters don’t like it.

And these are the people that will likely put the weight back on because they’re not looking at the longer term picture and refusing to read any statistics that show it’s not a miracle cure.

AngelicKaty · 18/12/2025 16:08

@PiriPiriMenopause YABU OP. In 2022/2023, 69.2% of men and 58.6% of women were overweight in the UK - and we're getting fatter each year. Size 14 isn't going anywhere.

SilenceInside · 18/12/2025 16:11

@Eyeshadow so these ignorant people who refuse to read the correct information might start to put weight on when/if they stop taking WLI…. So what would they do then in those circumstances? Well, start taking it again, and then either continue to take it or take it for a while and make the necessary changes if they can. Or a combination. What is the issue with that happening?

MargoLivebetter · 18/12/2025 16:14

Ah @Eyeshadow so you mean poor people? They're the ones who wouldn't change their lifestyles and look at the long term picture? Have I understood you correctly?

Also, who thinks it is a miracle cure? Every single person who has cut their calories for months and months and months while taking WLI knows it isn't a miracle cure!

lemonts · 18/12/2025 16:14

Eyeshadow · 18/12/2025 16:08

Why would it sound like I wasn’t pro WLI when I said it should be available on the NHS so that people get support and poor people can take it too??

I said it would still be cheaper than then the issues caused by obesity.

But because I’m not saying it’s a miracle cure then posters don’t like it.

And these are the people that will likely put the weight back on because they’re not looking at the longer term picture and refusing to read any statistics that show it’s not a miracle cure.

Literally no one is saying it's a cure! Obesity is a chronic disease, often one without a cure. The longer term picture is that WLI address the symptoms of the disease not that they cure the disease. I ask you again, are you against all medications that help manage symptoms of chronic disease or just WLI? Would you suggest that people shouldn't take statins for example as they don't cure high cholesterol?

lemonts · 18/12/2025 16:17

If my mother stops taking the medication that helps control her arthritis, it will flare up again. Should she stop taking it as after all it isn't curing her arthritis? Maybe she should think really hard and reprogram her brain so that it doesn't feel as painful.

ClaireBlunderwood · 18/12/2025 16:21

My BMI currently hovers towards 25 having put on a stone since the menopause which takes me from being happy with my body to unhappy. I have also had a lifetime of thinking about food, worrying about my weight, going on endless diets, a mother calling me fat etc. No, I've never been obese or even medically overweight (but most certainly perceived as aesthetically overweight) but that doesn't not mean that body issues and guilt/obsession around food do not exist.

I know living with obesity is a different and serious condition and I don't want to compare my lifelong peripheral obsession around food and weight. However, I can tell you that GLP-1s have totally dialled it up. It feels like weight loss conversations are everywhere. Endless articles about it, instagram pushes, journalists with their 'look at me I lost four stone!' pieces. I also have close family members with experience of EDs and I worry about them too.

Sometimes it feels like the obese or formerly obese are gatekeeping the drug - no it's not for you, your food noise isn't enough, I need them to maintain my current BMI of 22 or whatever. As someone up thread said, why is someone who had a BMI of 30 but now has one of 23 more worthy of them than the person with the BMI of 27?

Eyeshadow · 18/12/2025 16:22

MargoLivebetter · 18/12/2025 16:14

Ah @Eyeshadow so you mean poor people? They're the ones who wouldn't change their lifestyles and look at the long term picture? Have I understood you correctly?

Also, who thinks it is a miracle cure? Every single person who has cut their calories for months and months and months while taking WLI knows it isn't a miracle cure!

No why are you trying to twist my words.

I said it should be available on the nhs so that even poor people can access it.
Why should the most disadvantaged (which are often the ones with malnutrition) not have the same access to healthcare as someone richer.

I don’t understand why people are so triggered over these injections and won’t hear of anything negative associated with them.

Multiple people on threads like these have said that people do not regain weight afterwards, that they can be on them for life, that they’ve not needed to make changes to their lifestyle, that there are no side effects etc.
Its like people refuse to hear facts.

The injections should be used as a tool for weight loss (similar to bariatric surgery) not a lifelong cure (because they’re not).

ClaireBlunderwood · 18/12/2025 16:23

I'm also interested in what they will do to our perceptions of beauty. Throughout history the beauty goalposts are constantly moving to make it more exclusive. If being very thin becomes more easily accessible, will the desirable body shape change? I think the very toned, worked-out body will be even more prized - people might be able to afford the drugs but having the personal trainers, the expensive skin refining treatments, the time to work out etc will become the next elusive goal.

Eyeshadow · 18/12/2025 16:23

lemonts · 18/12/2025 16:14

Literally no one is saying it's a cure! Obesity is a chronic disease, often one without a cure. The longer term picture is that WLI address the symptoms of the disease not that they cure the disease. I ask you again, are you against all medications that help manage symptoms of chronic disease or just WLI? Would you suggest that people shouldn't take statins for example as they don't cure high cholesterol?

Where have I said I’m against WLI?

IsItSnowing · 18/12/2025 16:26

AbbaCadaBra · 18/12/2025 15:43

Not all of us. I could afford it but I fear medication of any kind.

I am doing it the old fashioned way. It‘s slow.

I agree that you can put on weight whatever you do - especially for an emotional eater like me. The longest I kept the weight off for was 8 years and then I suffered a bereavement and it all went to pot. But I know I can do it and maintain the loss without medication so I am sticking with it.

I really believe that a lot of weight loss is to do with a mental game. Getting started is the main challenge. And the“food noise” quietens down if you have the right nutrition. I find that I have to abstain from sugar. If I eat it the food noise goes crazy. But without it my appetite regulates itself exactly as reported by people on medication.

I wish this was true. I'm vegan. I eat whole food plant based - have for years. I stay away from upf. My diet, on paper, looks great.
Before jabs, I ate too much. That simple. Good wholesome food but too much of it.
So why didn't I cut back? Well, I did, many times. I'd stay on a diet for 2-3 months max. I'd lose a few stones. Then I'd crumble and give in because every day was a fight against wanting to eat.
From the first jab of mounjaro, my food obsession stopped. It was like a light being turned off.
I've been on it over a year. Lost nearly 6 stone now.
I eat what I always did. Just less. I count calories every day. I stick to them. For over a year. This for me is the big change. I've stuck to it. Not for a short time, for a long time. It's quite miraculous.

NikkiPotnick · 18/12/2025 16:27

ClaireBlunderwood · 18/12/2025 16:23

I'm also interested in what they will do to our perceptions of beauty. Throughout history the beauty goalposts are constantly moving to make it more exclusive. If being very thin becomes more easily accessible, will the desirable body shape change? I think the very toned, worked-out body will be even more prized - people might be able to afford the drugs but having the personal trainers, the expensive skin refining treatments, the time to work out etc will become the next elusive goal.

I agree. Being thin had a rarity value which is being lessened. I've bought a healthy BMI for thirty odd quid a week, less when you consider reduced food spend. Lots more like me. So of course the social signals it sends will change, notwithstanding that people have made good points about the obesity and poverty link possibly becoming even more stark until more extensive rollout.

HereforonedayonlytoavoidStrangerThingsspoilers · 18/12/2025 16:31

lemonts · 18/12/2025 15:50

I was responding to a poster who was pontificating on whether she would take them or not. Just out of interest what other medications do you consider to be a news topic worth discussing? IVF is the only other type of medical treatment that I can think of that people seem to see fit to comment on.

Topics for discussion? Latest cancer treatment breakthroughs, any drug that can halt the progress of bastard Alzheimer's, any new drug that can help with menopause or anxiety. Also MND, because someone close to us has it. I actually wouldn't discuss IVF because I'm past the child-bearing stage of life.

lemonts · 18/12/2025 16:33

Eyeshadow · 18/12/2025 16:22

No why are you trying to twist my words.

I said it should be available on the nhs so that even poor people can access it.
Why should the most disadvantaged (which are often the ones with malnutrition) not have the same access to healthcare as someone richer.

I don’t understand why people are so triggered over these injections and won’t hear of anything negative associated with them.

Multiple people on threads like these have said that people do not regain weight afterwards, that they can be on them for life, that they’ve not needed to make changes to their lifestyle, that there are no side effects etc.
Its like people refuse to hear facts.

The injections should be used as a tool for weight loss (similar to bariatric surgery) not a lifelong cure (because they’re not).

I don’t understand why people are so triggered over these injections and won’t hear of anything negative associated with them.

People aren't triggered and your use of the word suggests you don't understand what 'triggered' means. Of course there are downsides as with all medications there can be side effects which for a minority of people will outweigh the benefits

Multiple people on threads like these have said that people do not regain weight afterwards,

I have never seen anyone say that people don't regain weight, though I have seen people say that regaining weight can be avoided by remaining on the injections. Of course some people have posted that they themselves haven't regained weight, which is true for them.

that they can be on them for life

People could be on them for life so not sure what your point is

that they’ve not needed to make changes to their lifestyle,

it depends what you mean about changing lifelstyle, but given that not all obese people are shovelling junk into their faces, in fact many are simply eating much to much of what is otherwise a healthy diet, it's not clear what 'lifestyle change you think they should be conductiong.

that there are no side effects etc.

There are people who have no side effects, in fact the vast majority will have no side effects. bearing in mind the high incidence side effects are about 1 in 10, that means for those most common side effects 9 out of 10 people won't be having them. I have never seen anyone post suggesting that these drugs have no known side effects.

The injections should be used as a tool for weight loss (similar to bariatric surgery) not a lifelong cure (because they’re not).

This is your opinion, nothing more, nothing less. Once again I ask what other drugs that tackle symptoms should people have to stop taking, in your opinion, because they aren't a cure.

SwingTheMonkey · 18/12/2025 16:36

Eyeshadow · 18/12/2025 15:50

That’s amazing well done you.

You must be consciously making an effort of what you put in your body and things now though or are you just eating what you want and when you want?

If you go back a few comments you’ll see the one I posted in reply to your original comment that people on WLI put weight back on because they haven’t changed their lifestyles or mindset (paraphrasing).

To recap - I’ve completely overhauled my diet. I know how much I weigh and weigh daily. I know how many calories I need to maintain my weight. I know what foods make me retain water. I know how much protein I should be eating daily. I strength train 4x a week at the gym and aim for 10k steps a day.
Just like lots of people on this medication. Because frankly, it’s too expensive to fuck it up.

HereforonedayonlytoavoidStrangerThingsspoilers · 18/12/2025 16:36

lemonts · 18/12/2025 16:17

If my mother stops taking the medication that helps control her arthritis, it will flare up again. Should she stop taking it as after all it isn't curing her arthritis? Maybe she should think really hard and reprogram her brain so that it doesn't feel as painful.

I was about to say you are conflating two very different medical conditions but I just looked up arthritis to see what causes it and it can also triggered by lifestyle choices so there you go.

MargoLivebetter · 18/12/2025 16:38

@Eyeshadow so who are the people who won't make the changes and look at the long-term picture. In your post you referred to poor people, so I'm not sure which other group of people I'm supposed to conclude you were referring to. Please help me to understand better.

I'm not triggered by WLI. What I find immensely frustrating is the posters who give their opinion about how they don't work, will fail, aren't a miracle cure, will cause other problems, will demonise overweight people who don't use them, are bad for those with eating disorders, will result in everyone looking like Sharon Osborne, will result in horrific long term issues that no one knows about but will happily speculate wildly about, that everyone on them will end up putting all the weight back on and more, will result in world annihilation and so on! And these opinions are expected to be given the same weight as real factual evidence from scientists and those who actually use WLI. That is what I try to counter.