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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

Will sertraline work? When?!

158 replies

Pelvicpaininthebum · 11/10/2025 10:08

I've been having anxiety attacks and panic attacks.

I started Sertraline 11 days ago at 25mg and then went up to 50mg 4 days ago.

I feel my anxiety is worse if anything. I've got constant low level anxiety and am so worn out from it. I'm waking early and feeling panicky.

Will the sertraline end up working? I feel so desperate for it to.

OP posts:
Rituelec · 11/10/2025 14:07

only worked for me on a dose of 150mg

HourlyTime · 11/10/2025 15:06

Pelvicpaininthebum · 11/10/2025 14:07

Well done form keeping yourself distracted. I'm finding it too hard, I'm just focussing on it all the time. And I'm so exhausted I couldn't imagine going for a jog. Is it not making you tired?

Just remember to be kind to yourself, it's really brave even to be trying it.

I'm definitely exhausted from it, but I'm forcing myself to do things - (it helps there are some tasks I have to do) but it's absolutely okay if you can't focus and just need to rest.

Thinking logically has helped me - like "Oh, okay, I'm on extra high alert, this is really hideous, but it's just my body's way of keeping me safe and a reaction to the new medication".

I feel like although the anxiety/stress is a high, uncomfortable level, in not fighting it, I can let it just sit there within me.

If that makes any sense!

SendTheNextOneIn · 11/10/2025 15:58

Pelvicpaininthebum · 11/10/2025 12:55

Thanks everyone.

@SendTheNextOneIn I'm so sorry that sounds awful. Did you start straight on 50mg. As well as the raised anxiety I feel so tired and spaced out. Do you have this?

Yes my doctor just started me straight onto 50mg. It’s definitely affecting my sleep I think. I’ve been taking it in the morning as suggested but the last few nights I’m really not sleeping well. But I’m not the best sleeper anyway so I’m not really sure if it’s the meds or just me. But poor sleep obviously doesn’t help my mood.

SendTheNextOneIn · 11/10/2025 15:59

Sorry yes I’m also noticing I’m a bit spaced out. Like brain fog. Which is not helping me support my daughter right now.

Fluffypotatoe123987 · 11/10/2025 16:26

6 weeks. Propanolol 80mg works str8 away though

Pelvicpaininthebum · 11/10/2025 18:43

HourlyTime · 11/10/2025 15:06

Just remember to be kind to yourself, it's really brave even to be trying it.

I'm definitely exhausted from it, but I'm forcing myself to do things - (it helps there are some tasks I have to do) but it's absolutely okay if you can't focus and just need to rest.

Thinking logically has helped me - like "Oh, okay, I'm on extra high alert, this is really hideous, but it's just my body's way of keeping me safe and a reaction to the new medication".

I feel like although the anxiety/stress is a high, uncomfortable level, in not fighting it, I can let it just sit there within me.

If that makes any sense!

You feel like you're on high alert too? I feel so agitated tonight, it's horrible 😭

OP posts:
ninjahamster · 11/10/2025 18:46

Pelvicpaininthebum · 11/10/2025 18:43

You feel like you're on high alert too? I feel so agitated tonight, it's horrible 😭

I remember that feeling. I really struggled for a couple of weeks then it steadied. About 6 weeks in I was driving home from the school run, the sun came out and I suddenly felt really happy! I’d forgotten that feeling! It was wonderful.

Pelvicpaininthebum · 11/10/2025 19:20

ninjahamster · 11/10/2025 18:46

I remember that feeling. I really struggled for a couple of weeks then it steadied. About 6 weeks in I was driving home from the school run, the sun came out and I suddenly felt really happy! I’d forgotten that feeling! It was wonderful.

Thank you @ninjahamster

I've forgotten happiness too. I feel like I'm just clinging on.

I feel so uncomfortable in my own skin. I just want to rip it off or scream.

How much longer do I have to feel like this for I just can't cope.

OP posts:
HourlyTime · 11/10/2025 19:36

Pelvicpaininthebum · 11/10/2025 18:43

You feel like you're on high alert too? I feel so agitated tonight, it's horrible 😭

Exactly that, ultra high alert, jumpy, agitated, my anxiety is on the edge of a panic attack. My heart rate is higher than usual too so it's definitely physical.

It takes a few weeks for your brain to adapt to how the sertraline works, so it's actually a grest sign that it has started doing its thing.

I'm watching Strictly and trying to focus on breathing deeply to ease the anxiety a little x

Ataloss38 · 11/10/2025 20:25

Hello! I’m on day 4 of 25mg, have had quite a few what I can only describe as drinking 20 coffee's!! Jelly legs and have to lay down.

Pelvicpaininthebum · 11/10/2025 21:34

HourlyTime · 11/10/2025 19:36

Exactly that, ultra high alert, jumpy, agitated, my anxiety is on the edge of a panic attack. My heart rate is higher than usual too so it's definitely physical.

It takes a few weeks for your brain to adapt to how the sertraline works, so it's actually a grest sign that it has started doing its thing.

I'm watching Strictly and trying to focus on breathing deeply to ease the anxiety a little x

You sound so hopeful! Glad you've managed to watch Tele. I can't concentrate on anything.

I have two small children and in the day they are just constant which makes me feel even worse.

We should keep checking in with each other...?

OP posts:
Pelvicpaininthebum · 11/10/2025 21:36

Ataloss38 · 11/10/2025 20:25

Hello! I’m on day 4 of 25mg, have had quite a few what I can only describe as drinking 20 coffee's!! Jelly legs and have to lay down.

I definitely haven't had that. I've been very drowsy, whilst also being highly anxious!

OP posts:
Rituelec · 11/10/2025 23:11

The high alert will fade soon. Promise. X

LuceeeeeLoobieeel · 11/10/2025 23:42

Hi OP I’ve been going through a hellish time and started on sertraline recently. I’m on day 5 of taking 25mg and start on 50 tomorrow. I had an absolute horrific day yesterday to the point I thought I would need to get myself admitted. I’ve hardly eaten for two weeks. I have bad work anxiety and I catastrophise.

I woke this morning feeling iffy but after an hour I started to feel better. I’m now able to drink a tea and eat a biscuit and get it down and my thoughts are not racing. It’s early days but I nearly gave up yesterday and I am so glad I didn’t. I don’t know what I would do without this community. Hang in there.

HourlyTime · 12/10/2025 06:32

Pelvicpaininthebum · 11/10/2025 21:34

You sound so hopeful! Glad you've managed to watch Tele. I can't concentrate on anything.

I have two small children and in the day they are just constant which makes me feel even worse.

We should keep checking in with each other...?

Yes definitely; how are you doing this morning?

I slept a bit better but not great; the high alert is still very much there at the moment! Day 3 for me.

I do hope you're feeling a bit stronger?

BadgesforBadgers · 12/10/2025 07:52

Yep, stick with it, it will work.

The last thing to go for me was the morning anxiety, but honestly it's worth persisting with.

Also, if you haven't already, download an App called ' DARE' and pay for the subscription version, it was a lifeline for me.

LuceeeeeLoobieeel · 12/10/2025 07:54

BadgesforBadgers · 12/10/2025 07:52

Yep, stick with it, it will work.

The last thing to go for me was the morning anxiety, but honestly it's worth persisting with.

Also, if you haven't already, download an App called ' DARE' and pay for the subscription version, it was a lifeline for me.

Is that app good for work type anxiety? Or more for things like flying and social anxiety etc

Pelvicpaininthebum · 12/10/2025 09:07

Rituelec · 11/10/2025 23:11

The high alert will fade soon. Promise. X

Thank you 🙏

OP posts:
Pelvicpaininthebum · 12/10/2025 09:09

LuceeeeeLoobieeel · 11/10/2025 23:42

Hi OP I’ve been going through a hellish time and started on sertraline recently. I’m on day 5 of taking 25mg and start on 50 tomorrow. I had an absolute horrific day yesterday to the point I thought I would need to get myself admitted. I’ve hardly eaten for two weeks. I have bad work anxiety and I catastrophise.

I woke this morning feeling iffy but after an hour I started to feel better. I’m now able to drink a tea and eat a biscuit and get it down and my thoughts are not racing. It’s early days but I nearly gave up yesterday and I am so glad I didn’t. I don’t know what I would do without this community. Hang in there.

Keep trying to eat, little and often. I'm struggling with really low appetite too. I've lost so much weight.

I've had points I've thought about going to a&e and have rung helplines.

Keep letting us know how you're doing.

OP posts:
Doggymummar · 12/10/2025 09:10

Pelvicpaininthebum · 11/10/2025 10:08

I've been having anxiety attacks and panic attacks.

I started Sertraline 11 days ago at 25mg and then went up to 50mg 4 days ago.

I feel my anxiety is worse if anything. I've got constant low level anxiety and am so worn out from it. I'm waking early and feeling panicky.

Will the sertraline end up working? I feel so desperate for it to.

I was on 200mg and it took about six weeks to kick in. That's a very low dose.

Pelvicpaininthebum · 12/10/2025 09:12

HourlyTime · 12/10/2025 06:32

Yes definitely; how are you doing this morning?

I slept a bit better but not great; the high alert is still very much there at the moment! Day 3 for me.

I do hope you're feeling a bit stronger?

I slept terribly, awake at 1am (after going to sleepy after 11) and couldn't go back to sleep so took half a lorazepam (0.5). Still couldn't sleep so took another half an hour later, then only slept till 5:30.

I'm thinking of calling the GP tomorrow to ask for zopiclone as I worry about lorazepam but unsure if you can take it with asthma. The lack of sleep feeds my anxiety.

I'm actually feeling a bit calmer this morning, but it's probably cos the lorazepam is still in my system.

Going to get up and get going now as have to take DS to football. Hoping getting out will help.

What are you doing today?

OP posts:
Pelvicpaininthebum · 12/10/2025 09:13

Doggymummar · 12/10/2025 09:10

I was on 200mg and it took about six weeks to kick in. That's a very low dose.

I'm scared of increasing it as know you then get side effects again every time you do?!

OP posts:
Neurodiversenamechange · 12/10/2025 09:15

Pelvicpaininthebum · 11/10/2025 10:08

I've been having anxiety attacks and panic attacks.

I started Sertraline 11 days ago at 25mg and then went up to 50mg 4 days ago.

I feel my anxiety is worse if anything. I've got constant low level anxiety and am so worn out from it. I'm waking early and feeling panicky.

Will the sertraline end up working? I feel so desperate for it to.

Are you neurodiverse by any chance? SSRIs made me worse. I needed a SNRI.

sunflower1022 · 12/10/2025 09:23

Pelvicpaininthebum · 11/10/2025 10:08

I've been having anxiety attacks and panic attacks.

I started Sertraline 11 days ago at 25mg and then went up to 50mg 4 days ago.

I feel my anxiety is worse if anything. I've got constant low level anxiety and am so worn out from it. I'm waking early and feeling panicky.

Will the sertraline end up working? I feel so desperate for it to.

I have been on Sertraline for five weeks now. I was on Fluoxetine before that but I had awful side effects (bad tinnitus, blurry vision, bad anxiety) and after sticking it out for two months my GP suggested switching to Sertraline.

Currently on 50mg and I can’t say I’m feeling much better really. I think my anxiety has improved a little bit but my depression is still as bad as ever.

I struggle to sleep but then I haven’t really had a good sleep for a long time.

I did not want to go back on ADs (was on them previously) but my husband persuaded me as I was spiralling downwards again fast and I attempted suicide a few years ago.

Hope we all feel a bit better soon. Bad mental health is so debilitating.

❤️

DoubleShotEspressox · 12/10/2025 09:38

I was on sertaline for years and they pretty quickly scaled me up to 200mg and for the first two months I could barely function.

Anxiety, stomach upset, not feeling in the same room as everyone else, couldn’t sleep, couldn’t eat, jitters, panic. However, I was so mentally poorly and passively suicidal that the trade off was worth it.

Despite feeling worse initially, I think about two months into it I just woke up one day and didn’t feel like there was a weight on my chest. It saved my life, undoubtedly. I would encourage you to continue and see it through a while longer.

Because I struggled so much initially the GP did also prescribe diazepam for seriously bad moments and I was also taking a high dose of quetiapine at the same time. Propranolol works too.

Grounding techniques (five senses, what can you smell, what can you feel etc) and breathing exercises - as pathetic as they sound when you feel this bad, did help me not totally crack up and lose my grip on reality.

Also taking the meds in the evening helped me manage the side effects more.

Wish you the best Op.

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