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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

Doctors/Nurses/Dietitians/healthcare professionals, what are you real and honest beliefs about the whole weight loss injection moment we are having?

331 replies

Banrockmystation · 19/04/2025 19:53

A genuine thread for me who is too afraid to ask in real life. For context I’m in my 40s with pcos, at least 2.5 stone overweight and despite exercising 4 times a week and calorie tracking etc for the last few years my weight issues continue.
I don’t have an opinion on other people being on the injections. My reason for asking is because despite probably being a candidate for them and knowing how hard I try to control weight, there’s something that stops me.
I worry that there is more to it than what is being shown by the media and that there isn’t enough research done on long term effects etc? Aibu? Is that just fear or an actual possible concern that others in the industry have too?
Despite my weight, I’m heart healthy and fitter than I’ve ever been.
Thanks!

OP posts:
AppleDumplingWithCustard · 20/04/2025 22:24

I wish @Cityandmakeup would come back and enlighten us as to why she can’t wait for side-effects and fall out.

Orangeandpurpletulips · 21/04/2025 14:46

PinkArt · 20/04/2025 18:12

Ironically the stigmatising is working the other way - us lazy fatties are proving how lazy we are by 'cheating' using WLI, rather than just gritted teeth and will power.
Lazy if we stay obese, lazy if we use the WLI and now the fear of being lazy if we don't!

It is. I just laugh.

Cloudysky81 · 21/04/2025 14:53

We should be putting large percentages of the population on them.

There will undoubtedly be side effects, but the consequences of 20-30% of the population being obese are worse. Both on an individual and public finances/NHS resources point of view.

UndertheCedartree · 21/04/2025 17:48

Can these medications work if you have gained weight due to mental health medication?

SergeantDawkins · 21/04/2025 18:08

Is anyone else in the medical field (my sister in law is a nurse and mentioned this in conversation) concerned about a potential increase in osteoporosis in the future linked to middle aged/menopausal women using WLI?

MissConductUS · 21/04/2025 19:01

UndertheCedartree · 21/04/2025 17:48

Can these medications work if you have gained weight due to mental health medication?

They work by suppressing your appetite, so you drastically reduce your caloric intake. The cause of your weight gain shouldn't matter, unless you've dramatically lowered your basal metabolic rate.

Scirocco · 21/04/2025 19:18

UndertheCedartree · 21/04/2025 17:48

Can these medications work if you have gained weight due to mental health medication?

Yes, they should. In theory, they might actually be particularly beneficial for people who have gained weight due to the side effects of medications like antipsychotics. Antipsychotic-related weight gain can be due to appetite stimulation (people can feel much hungrier and not recognise when they've eaten enough) and antipsychotics can carry an increased risk of diabetes. So, a medication that targets those same pathways in a different way could be really helpful.

LaurieFairyCake · 21/04/2025 19:23

sergeantdawkins

this is definitely true for me. I’ve lost 3 stone on WLI and have very little muscle tone as frankly too tired to do weights apart from walking. It’s been the only side effect of the drug for me, that I’m really knackered

what I’m hoping for is once I get to maintenance (in 10 pounds time, so about 4 months) I will get a bit more energy from my maintenance calories, should be able to add a couple of hundred calories and that will then give me the energy for using weights.

I still manage at least an hours walk every day but I’m too tired to add in weights at the moment.

UndertheCedartree · 21/04/2025 19:28

Scirocco · 21/04/2025 19:18

Yes, they should. In theory, they might actually be particularly beneficial for people who have gained weight due to the side effects of medications like antipsychotics. Antipsychotic-related weight gain can be due to appetite stimulation (people can feel much hungrier and not recognise when they've eaten enough) and antipsychotics can carry an increased risk of diabetes. So, a medication that targets those same pathways in a different way could be really helpful.

Thank you - that gives me hope!

PinkArt · 21/04/2025 19:35

SergeantDawkins · 21/04/2025 18:08

Is anyone else in the medical field (my sister in law is a nurse and mentioned this in conversation) concerned about a potential increase in osteoporosis in the future linked to middle aged/menopausal women using WLI?

Did she mention where she's read the research about this? To the best of my knowledge osteoporosis isn't currently listed as a known side effect of either Wegovy or Mounjaro.
Presumably she's concerned about the effects of carrying additional weight on older women's bones and joints as well?

Oldgalgames · 21/04/2025 22:00

PinkArt · 21/04/2025 19:35

Did she mention where she's read the research about this? To the best of my knowledge osteoporosis isn't currently listed as a known side effect of either Wegovy or Mounjaro.
Presumably she's concerned about the effects of carrying additional weight on older women's bones and joints as well?

It's well known that significant and prolonged calorie deficit causes muscle loss and impacts bone mass.

SergeantDawkins · 21/04/2025 22:02

LaurieFairyCake · 21/04/2025 19:23

sergeantdawkins

this is definitely true for me. I’ve lost 3 stone on WLI and have very little muscle tone as frankly too tired to do weights apart from walking. It’s been the only side effect of the drug for me, that I’m really knackered

what I’m hoping for is once I get to maintenance (in 10 pounds time, so about 4 months) I will get a bit more energy from my maintenance calories, should be able to add a couple of hundred calories and that will then give me the energy for using weights.

I still manage at least an hours walk every day but I’m too tired to add in weights at the moment.

This is a worry. Thanks for sharing your story. I hope you’re able to get some energy back.

SergeantDawkins · 21/04/2025 22:06

Oldgalgames · 21/04/2025 22:00

It's well known that significant and prolonged calorie deficit causes muscle loss and impacts bone mass.

This.

SilenceInside · 21/04/2025 22:17

@SergeantDawkins would you say then that it’s unwise for someone like me to be using Mounjaro to lose weight, as I’m middle aged and female, as it will cause me to develop osteoporosis in a few years time? I’ve been taking it for 9 months plus, so presumably the damage is already done?

PinkArt · 21/04/2025 22:31

Oldgalgames · 21/04/2025 22:00

It's well known that significant and prolonged calorie deficit causes muscle loss and impacts bone mass.

So the weight loss then and not the medication. Same as eat less move more, weight watchers, intermittent fasting etc.

Thisismetooaswell · 21/04/2025 22:38

Kitkate21 · 19/04/2025 20:39

I did it for 8 weeks. It gave me a huge hoof up the backside. I lost 2lbs a week. What I did do though was absolutely change every single thing I needed to. Protein intake, water intake, exercise every single day. I started in July last year and now I've lost 2stone and 2lbs but 90% of this is will power, commitment to exercise and food control. I was only a size 12 but I'm short. I never went up a dose. Stayed on 2.5mg so can't really say I had much in the way of side affects. I see it as a tool to reset your Lifestyle changes. Honestly wouldn't know what my go thought. I know a lot of people on it that have lost stones and stones but once stopped it's come back on once they eat normally again. I had to force myself to eat and it wasn't nice. But I've kept the weight off and I train every day. I feel great.

I am the same size. Which one did you take please?

QueefQueen80s · 21/04/2025 22:58

PinkArt · 21/04/2025 22:31

So the weight loss then and not the medication. Same as eat less move more, weight watchers, intermittent fasting etc.

But far likely for people to get to the lower weights with the injections. It’s if they know when to stop

SilenceInside · 21/04/2025 23:00

Why would people taking injections not know when to stop? Are they different to other people who are losing weight? Would I not know when to stop, for example? Presumably I’d have to start lying to my pharmacy in order to keep getting a prescription if I became underweight.

ArtTheClownIsNotAMime · 21/04/2025 23:06

SilenceInside · 21/04/2025 23:00

Why would people taking injections not know when to stop? Are they different to other people who are losing weight? Would I not know when to stop, for example? Presumably I’d have to start lying to my pharmacy in order to keep getting a prescription if I became underweight.

Quite. The barrels people will scrape to justify their disapproval of these drugs are astonishing, and I say that as someone who's never taken them.

PinkArt · 21/04/2025 23:21

QueefQueen80s · 21/04/2025 22:58

But far likely for people to get to the lower weights with the injections. It’s if they know when to stop

To a healthy weight you mean? None of the legit prescribers will continue to prescribe if someone's weight drops below a BMI of 22 or 23. Presumably they would be at no more risk of osteoporosis than any other middle aged woman of their new weight? And would have removed a lot of pressure from their bones at the same time.

Radionowhere · 22/04/2025 00:01

Useful to aid weight loss in the clinically obese who's health is being compromised by the weight they're carrying however it's a short term fix. Once you come off them you have to maintain which means lifestyle change.

Dodgethis · 22/04/2025 00:09

CakeIsNotAvailable · 19/04/2025 19:56

GLP-1 agonists have been licenced for the treatment of diabetes since, iirc, 2009. They do seem to be pretty safe. I'm a GP and less than 12 months ago I was morbidly obese. Thanks to GLP-1s I now have a BMI of 22.5. I think that the benefits of losing almost 50kg are likely to outweigh the risks in my case. I accept that the risk/benefit equation may be different for someone starting from a lower BMI.

A question, out of interest. As a medical professional did you go for any regular monitoring eg of liver function or just trust the process?

UndertheCedartree · 22/04/2025 00:28

Oldgalgames · 21/04/2025 22:00

It's well known that significant and prolonged calorie deficit causes muscle loss and impacts bone mass.

You need to exercise to counteract this.

Galwaygirlxxx · 22/04/2025 00:48

EM consultant.

I'm on mat leave but colleagues are seeing patients with very bad side effects. We are seeing a lot of gastro issues at the moment. Not sure how many the total is though!

If you are on them, please see your GP and drink a lot of water. Renal and nephrology issues, I'd be extra cautious.

Galwaygirlxxx · 22/04/2025 00:50

CakeIsNotAvailable · 19/04/2025 19:56

GLP-1 agonists have been licenced for the treatment of diabetes since, iirc, 2009. They do seem to be pretty safe. I'm a GP and less than 12 months ago I was morbidly obese. Thanks to GLP-1s I now have a BMI of 22.5. I think that the benefits of losing almost 50kg are likely to outweigh the risks in my case. I accept that the risk/benefit equation may be different for someone starting from a lower BMI.

That is exactly what we are saying in Ireland. The risks of being morbidly obese outweigh the risks for the meds.

Fair play to you for losing that. I was obese too and felt that patients didn't take me as seriously. Lost the weight thanks to running and giving up the chocolates!