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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

To just remind you that autism is genetic?

261 replies

robotgun · 02/07/2024 16:05

Research tells us that 60 to 90% of the risk for autism comes from your genome. Maternal and paternal age are also a significant factor. Also genetic variants exist that cause autism-like behaviours and go undiagnosed because we don't routinely run genetic tests on our children. We also don't routinely institutionalise children that are different to their peers.

There's 'more' autism because people are having babies at older ages. And we are better at spotting autism.

It isn't heavy metals, microplastics, or the MMR.

Sorry, but it seems like every day I open this app and there's a new post saying 'What's going on with all this autism around, eh?' and a slew of replies blaming environmental factors that have no science behind them whatsoever. Or, worse, blaming mothers for reproducing too late in life or eating tuna in pregnancy or taking prescribed meds.

If you see enough of these threads every day you could well start to believe the nonsense that people write, much like people that read the Daily Mail every day start to believe that Meghan Markle is the devil.

Autism has always been here. It's not better or worse than it used to be.

OP posts:
Tinkerbot · 03/07/2024 21:00

ProfessorPeppy · 03/07/2024 19:09

@Alltheyearround

Autism and health issues: https://neurodivergentinsights.com/blog/autism-and-health-issues?rq=Auto&format=amp

Autistic burnout is a likely explanation for lots of conditions that have been attributed to autoimmune disease.

Also - and this one is REALLY interesting - the research is beginning to suggest that Parkinson’s disease might be lifelong ADHD, just the geriatric version: www.medicalnewstoday.com/articles/adhd-and-parkinsons#:~:text=ADHD%20and%20Parkinson's%20both%20affect,increase%20the%20risk%20of%20Parkinson's.

Can I just say that this is a link to a medical magazine and the actual report ends
Researchers still need further evidence to determine the link between Parkinson’s and ADHD, as well as the long-term effects of ADHD medications.
So the jury is still out on this. More research is needed.

ProfessorPeppy · 03/07/2024 22:12

Tinkerbot · 03/07/2024 21:00

Can I just say that this is a link to a medical magazine and the actual report ends
Researchers still need further evidence to determine the link between Parkinson’s and ADHD, as well as the long-term effects of ADHD medications.
So the jury is still out on this. More research is needed.

I did say that Grin here’s a couple of papers:

https://journals.sagepub.com/doi/full/10.1177/0963689720947416

https://rxisk.org/wp-content/uploads/2022/05/Baumeister-Is_Attention_Deficit_Hyperactivity_Disorder_a_Risk.4-2-1.pdf

ntmdino · 03/07/2024 22:23

BloodyHellKenAgain · 03/07/2024 16:10

😲😲😲 that has blown my mind. I wonder how that can happen when they are a product of the same egg and sperm?

If you think about it (and I'm saying this as somebody who studied genetics from a mathematical perspective at university many years ago, not a biologist), it totally makes sense. Mutations (DNA copying errors) occur at cell division time - and, when there are many orders of magnitude fewer cells, there's more of a chance that those mutations will become the dominant majority. Therefore, the earlier the mutation, the more likely it is that those cells will go on to heavily influence further cell divisions.

Therefore, it's vastly more likely to happen in the womb than at any other time, except maybe the creation of the sperm (given the much higher number compared with the number of eggs a woman carries).

EDIT: More than happy to be corrected by any biologists in the crowd...

Crazycatlady79 · 03/07/2024 23:03

FailBetter · 03/07/2024 06:23

They're the same thing!

I know: I was just trying to grab OP's attention!

Theordinary · 04/07/2024 05:51

BellaPommefritio · 03/07/2024 09:54

Maybe inflammation is an aspect to be considered then?

I wouldn't necessarily draw that conclusion. I think it's more likely that these conditions are genetically linked in some way. I believe there's research being done currently. There is a definite link with ADHD and Ehlers Danlos though, I know I've read that.

Errors · 04/07/2024 16:21

robotgun · 03/07/2024 15:43

My siblings have blue eyes, mine are green. Inheritance does vary.

Is your sibling your identical twin? As that’s what the post was referring to…

Draevans · 10/08/2024 10:30

Autism has a heritability of 90% which means it is genetic in origin.

Autism & ADHD “run” in families.

If you believe otherwise, please do some research.

Acinonyx2 · 10/08/2024 14:01

it means it has a substantial genetic component but to save me typing out an explanation of heritability this is pretty good:

www.thetransmitter.org/spectrum/autism-heritability-it-probably-does-not-mean-what-you-think-it-means/

x2boys · 10/08/2024 14:17

Genetic doesn't always mean.its inherited from parents, my son has a,rare chromosome disorder, thought t9 be the underlying cause of his autism and learning disabilities, but it was de novo and neither me or his Dad are autistic.

x2boys · 10/08/2024 14:21

BloodyHellKenAgain · 03/07/2024 14:30

Hi OP,
If autism is genetic then how us it possible I know identical twins. One has a formal diagnosis of autism and one doesn't. In fact, personality wise they are quite different girls.

I know identical twin girls ,whilst both have a diagnosis of autism, one is far more impacted then the other ,she's non verbal and at a special for children with severe and profound learning disabilities, whilst her.twin is very verbal and attends mainstream albeit with an EHCP etc.

LadyGabriella · 13/11/2024 19:02

RatHole · 02/07/2024 16:36

Most of my family are on the autism spectrum.

Having had a child suffer side effects from a prescribed drug and seen first hand how the pharmaceutical companies close ranks and deny I’ve lost my faith in them and no longer trust them to be honest. I was going to be part of an exposè in a National newspaper, I talked to a journalist and a doctor about this, but they were later warned to not discuss it and the article was dropped.

Thousands of people a week join the support group for this drug so it’s still ongoing. The company conceded to add the side effects to the drug info several years ago, but refuse to support any research, so any medical findings are down to patient groups who have done the work.

My autistic son went from being fine and supportable to being very high needs, unable to go to school and needing an awful lot of support.

I suspect more children’s/people’s autism is more disabling to them and their families because of certain pharmaceutical and dietary factors but the might of these huge corporations keeps it well under wraps and parents who talk about this are dismissed as conspiracy theorists or stupid.

I think a lot will come out about certain pharmaceutical products in the next 10-20 years. There are already films about certain coverups (Dopesick, Painkiller, Dark Waters). There will be more to come.

What drug?

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