Been hearing this over the years (different in-laws, not just one person) and just heard it again recently and it annoys me more each time.
Few examples (not in chronological order):
"I feel guilty we can't stay the night because it would be complicated as you don't live in a house." (even though we had an extra bedroom all ready to be used, this was back when we were renting a flat)
"I feel guilty I'm pregnant and you're not." (when we were struggling to conceive for several years)
"I feel guilty you're going through such a hard time." (when one of my parents was terminally ill)
"I feel guilty we won't get to see you as much. (when coming to visit once in a blue moon and only deciding to stay for a short time before heading off to spend considerably longer with another family member 20 min away).
It's just the whole "I feel guilty..." crap like it would somehow make everything ok even though some of these could have been easily rectified (if they indeed DID feel guilty).
Maybe IABU letting it get to me but would have preferred if nothing was said to begin with.