2 kids under five we have done this 3 or 4 times a year since the first was born when visiting family and going round the country and often go for a family room albeit in travellodge.
Fussy kids often fall asleep better in familar surrondings, each hotel room and bathroom is like a carbon copy of the next if you always use the same brand of hotel. Youngest is 2 and to avoid the bedtime battle he sat in his pushchair in the room lastime while i rocked him to sleep before he was carried into bed.
If you are worried about kids falling out without bedguards we have found that the legs go under quite nicely to make it montessori friendly and we rearrange the foldaway bed locations to suit us
All the travellodges we have done have allowed one end of the room to be quite dark so the kids have settled quite well.
My biggest tips tho to make this an enjoyable break , easy snacks and drinks, bananas and apples, individual pots of porridge, cereal bars, pastrys. Try to avoid fridge goods although we have found a bag of icecubes over 2 pints of milk in the sink over night to keep things fresh for individual cereal packets in the morning as long as everything is watertight is a godsend plus our toddler is very partial to his glass of milk upon waking. We have also ordered takeaway to the hotel to avoid the eat out battle when little ones are impatient and tired. It is often easier to have the big meal out middle of the day and do sandwiches and snacks for tea!
Tablets preloaded with downloaded favourite shows and a couple of small toys, such as a car, pack of snap cards or a colouring book and pencils can keep most kids entertained for a few days easy enough especially if wear them out while on your break.
Enjoy the break! we found the more you do it while they are young the easier they adapt.