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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

Genetic cancer testing

31 replies

Thedarksideofthemoon30 · 15/03/2021 16:57

I have a strange feeling that I’m going to have some sort of cancer in the future. I have no idea why.

My mum died of stomach cancer 11 years ago but when she had me she had a hysterectomy 6 months later because she wouldn’t stop bleeding. They found cancer when they removed it.

My auntie also had breast cancer.

I would love to have the gene test but obviously I have no living relative who has cancer. Can you have it done without one?

Iv already had hpv cells removed from my cervix 5 years ago.

OP posts:
Thedarksideofthemoon30 · 15/03/2021 18:44

Bump

OP posts:
bitingcat · 15/03/2021 18:47

I wish I could give you some answers OP but I can't do bumping for you. Flowers

steff13 · 15/03/2021 18:48

I got it because my mother died of breast cancer and her father died of colon cancer. Why would you have to have a living relative with cancer? My doctor told me it was the type of cancer they had and the age they were diagnosed that mattered.

happyjack12 · 15/03/2021 18:50

there are private genetic test centres in the UK.

chinateapot · 15/03/2021 18:52

You need to see your GP and discuss a referral to a clinical genetics service where they’ll be able to do a detailed history and risk assessment for you. They may then be able to offer genetic testing if you want it (there are pros and cons). This will only test for known genes involved in cancer pathways and they’ll only test for those they think you’re at risk of having. If tests are negative but they still think you’re higher risk than average they may be able to discuss screening options with you.
Good luck - GP is the place to start.

steff13 · 15/03/2021 18:53

I'm in the US, those were the criteria for my insurance to pay for the test. I could have paid for it myself.

SwedishEdith · 15/03/2021 18:53

What types of cancer can be tested for?

I have cousins and aunts who died of breast cancer and have tested positive for the BRAC gene. But I was told I don't qualify for a test as I don't have a direct relative of tested positive.

How old are you OP? There's a tipping point where your likelihood of getting breast cancer is the same whether genetic or not (I think it's sometime in your early 40s).

twoofusburningmatches · 15/03/2021 18:56

From my experience: you can go to your GP and they will consider your family history and if that meets the current threshold, they will refer you to a genetic councillor. The genetic councillor will ask even more questions about your family history/lots of forms to be filled in. It is easier to do testing with a living relative who had the form of cancer you think might be genetic. But there’s also basically a bank where they have been collecting cancer tumours for years and they can be tested.

Threeorfour · 15/03/2021 19:05

Are you Ashkenazi Jewish? They have a 1 in 40 risk of having the BRCA gene. With a family history of breast cancer and being Ashkenazi Jewish, your GP may refer you for testing.

Stuckhere2021 · 15/03/2021 19:09

Hi OP. You say “the gene test” - there is no such thing. Cancer genetic testing tests for gene mutations - we all have “the cancer genes”. Normally you need an affected relative / known mutation carrier so that you can be tested for the mutations they carry. That said, there are common mutations that in theory anyone could be tested for but it is not done on the NHS as far as I know - only as part of research studies. Before any genetic testing, a calculation is done to give an indication of the likelihood of finding a mutation. This is based on your family history ie the cancers in your close relatives, age they developed the cancer, multiple cancers (primary cancers ie different tumours not spread) and any known mutations. Red flags are cancers at an unusually young age (eg under 40 for breast cancer), patterns of cancers across siblings that are unusual. I have some experience of working in a genetics clinic and there was a family of 11, 9 of whom had died of cancer. But - they were all at an age when cancer is common, most smoked and some were heavy drinkers. It was concluded a hereditary element was unlikely.

I feel for you being worried like this but cancer genetic testing is not yet at the point of ease that people may think. There is still much more unknown than known.

Threeorfour · 15/03/2021 19:24

www.jnetics.org/

If you're Ashkenazi Jewish, you can get testing for the BRCA mutation here for £250.

balkanscot · 15/03/2021 19:30

I was given one at my medical team’s suggestion after I developed breast cancer - red flags were my dad and aunt (both had had breast cancer and both died from it - my dad actually died from prostrate cancer in the end). After I developed BC, I got immediate referral to the genetics unit and got tested - I got the result - BRCA2 positive. Then my brother got tested as well- he also tested BRCA2 positive.

balkanscot · 15/03/2021 19:31

Forgot to say my dad and my aunt, who was his sister.

Buttercupcup · 15/03/2021 19:33

I work with stomach cancer patients. There is a mutation called HER2 which can be tested for when stomach cancers are diagnosed, if a patient is positive for HER2 with a strong family history of cancer we refer their children/immediate family to a genetics clinic for counselling/testing. It is worth a discussion with your GP if you have a strong family history and if warranted they will be able to refer you to a genetics clinic at least for a discussion of risk. The thing they look at is how many relatives and at what age they developed cancer as below a certain age the risk of a genetic link is higher. This can also be done privately starting at around £300 for an initial consult.

everythingbackbutyou · 15/03/2021 19:39

OP, are you meaning stomach cancer or uterine cancer?

Suzi888 · 15/03/2021 19:42

But what happens if you do carry the gene? Would you have the preventative surgery?
I’ve considered it myself as my dad had pancreatic cancer and my grandfather also had either pancreatic or stomach cancer no-one can remember for sure and he died very young. If you carry a stomach cancer gene, is there even anything you can do about it? Confused I don’t know if it would cause more worry and angst knowing I’d definitely get cancer.

Thedarksideofthemoon30 · 15/03/2021 19:43

Thank you!

My mum was 41 when she had me and then died of stomach cancer at 59. They didn’t give her any chemo or anything after they found the womb cancer and actually left in her ovaries. She was diagnosed with stomach cancer and died 6 months later although she had symptoms for a year before she chose to go to the doctors.

My auntie had breast cancer but I’m not sure what age I just remember her not having a breast growing up.

I don’t know why I have such a strong feeling that I’m going to get it at some point in the future. 😔

OP posts:
TillyTopper · 15/03/2021 19:46

Why not just use 23andme (or similar)?

Thedarksideofthemoon30 · 15/03/2021 19:46

Either, stomach, womb(?), breast..

Ahhh 😭

OP posts:
billypopop · 15/03/2021 19:50

@SwedishEdith

What types of cancer can be tested for?

I have cousins and aunts who died of breast cancer and have tested positive for the BRAC gene. But I was told I don't qualify for a test as I don't have a direct relative of tested positive.

How old are you OP? There's a tipping point where your likelihood of getting breast cancer is the same whether genetic or not (I think it's sometime in your early 40s).

If your direct relative does Not have the BRCA gene change Seen in your relatives you do not need a test. If your direct relative is untested, you should ask your GP to refer you to local clinical genetics service.
Badgerstmary · 15/03/2021 19:55

Hi op, I was recently diagnosed with a lesser known gene called AML. It increases risk of several cancers including pancreatic, breast, ovarian...
Unfortunately my mum ended up passing away of leukaemia having had ovarian cancer, her sister of bile duct cancer & their dad of stomach cancer. My sister & cousin are all unfortunately AML positive. I would definitely enquire at your GP’s taking with you as full a family history as possible. If they are unable to help then maybe try going private. Good luck.

Belledan1 · 15/03/2021 20:04

I have had the tests 6 to 7 ears ago. I am a high carrier for breast and ovarian. I had my ovaries out as had my children now. I get checked yearly for breast. Have mri too. Under 50. Both my mom, my grandmother and great grandmother died of ovarian cancer before 45 and two had breast previously too. I got it done through nhs the test. They look at mothers side for cancer mainly. I think there I'd a big waiting list now for tests. Mine was done before Angelina and the girl from liberty x talked about their story.

Belledan1 · 15/03/2021 20:06

Which made people go Gp more. I am 80 per cent BRac gene for both but having ovaries out has helped.

Belledan1 · 15/03/2021 20:08

Sorry meant to say all my family members had died when had the tests.

DestinyIsAll · 15/03/2021 21:38

Hi Op, I have just been through this, testing for BRCA 1 and 2 gene mutations. After an eight week wait I had my results a few days ago. I was diagnosed with breast cancer in July ‘20 at 50, my sister too, very early last year at 51, I also had a maternal cousin who had (and recovered from) testicular cancer though that wasn’t necessarily relevant. My dad died of cancer and my (paternal side) cousin also died very young a few years ago of ovarian cancer, her age being a major factor. My breast surgeon was quite dismissive, in a trying to be reassuring way but came over to me as dismissive, and didn’t refer me initially saying it was likely just coincidence.

I went to my GP and she was completely supportive, the referral had to be via the consultant so she promptly wrote to him asking for a referral, which he did. My mum died young of a non cancer related illness which I think helped sway things because she was an uncertainty. Once the referral has been done you then do a more detailed family medical history with the genetics clinic and if you meet their own criteria they will go ahead. They felt there was sufficient cause to test both me and my dsis because of us both having BC around 50 and also the young age ovarian link with our cousin.

My understanding is that the only way to get an NHS referral is to have what appears more than a coincidence level (the incidence of which is much higher than you might think) of first and second degree relatives, to show need and get a referral either via a consultant or through your GP. I don’t think they will do it on the NHS unless you have in their view a significant history, not limited to but including relevant cancers, often typically breast, ovarian and prostate, coupled with younger than average ages of diagnosis.

If you can ascertain a bit more detailed family history of close relatives in the last few generations you might find enough justification to go to your GP?

I already had a mastectomy last year but did have counselling about the treatment options for a positive genetic result, but actually tested negative for BRCA gene mutation, this means no genetic very high risk of BC, prostate or ovarian cancers for my dc. Despite this they unfortunately still found a higher risk link to BC in my family, unrelated to BRCA, so my daughters will start screening 10 years earlier. I will get screened regularly anyway because of my own BC.

Just to add, for breast cancer patients having finished active treatment, they have changed the protocol of screening/checking for recurrence and I think this is really important to all women, especially also if there may appear a family link. If you are recalled only once a year, what they don’t want is women to put a high level of faith in annual screening, i.e., mammograms, and rely on that as their main method of checking. They now strongly emphasise, instruct really, that your main method of early detection on top of screening is once a month self checking. We all know we should do it, but I still don’t think a big % of women do it regularly and thoroughly. Everyone should self check properly once a month.