I travelled for 5 months in Asia & Europe with just hand luggage - there's one big trick, pack less, then remove half of what you've packed! And layer up, wearing your heaviest/bulkiest clothes when at the airport.
Forget shampoo/toothpaste/deodorant and buy when you're in the destination. I lived without make up or perfume.
I packed a camera with an extra lens, travel adaptor, first aid kit, notebook, pen, charger for phone, sarong/scarf, sandals, 2 trousers, 3 tops, 2 pairs of socks, 3 pairs of underwear and hand washed between wears.
When at airports I wore jeans, vest top, jumper, hoodie, denim jacket, baseball cap, put phone and passport, headphones, lip balm and tissues in my pockets and wore trainers.
I was budget travelling so I didn't care about 'nice' clothes though, I just looked casual scruffy 24/7. More difficult if you're needing to look nice or eating out while away and need your make up/nice clothes.
Now when I travel I pack double that just for a weekend away 