What time of year? As that will affect both the flight price and the weather. And when you say 'the usual' you are talking about culture, landscape, history (which are hard to shoehorn all into one week, but it is doable) but you don't mention sunshine or nights out - whether these are important to you will also massively affect your options.
I can think of a lot of places, but your criteria as it stands is quite broad. If you let us know if we are barking up the right tree I can probably come up with a few more ideas.
Boston would tick all your culture, history and landscape boxes, especially if you get out of town too in the autumn. It would also allow for girls' nights out and a bit of drinking. If you go in the summer there are good beaches within striking distance. It's not a long flight (about 7 hrs) and only 5hrs time zone difference.
Mexico is fabulous for history, culture, adventure sport, jungly wildlife, nights out, sunshine, everything! But it's a very long way to go for a week and flights only just squeak in at £500 if you go out of season. You'll save money when you get there though.
Turkey is brilliant too. I went with my family this summer and we were in a Unesco world heritage site Roman city and we were the only people there. The landscapes are dramatic and varied depending where you go in the country. It's relatively cheap to go there. I have always found it a safe-feeling place, but in a city or off the tourist beaten track you will have to be slightly more conservative than you normally would.
Going for something really different, a holiday to Russia would give you lots of history and culture. And vodka - lots of it! The nightlife scene in Moscow is very modern these days and there are restaurants, bars and cafes to suits all kinds of night out. The history is incredible - I saw evidence all around when I went there of a wild ride through history, everything from the buildings to the parks to the metro system is loaded with it. A train journey to St Petersburg would get you out in the countryside and landscape and on to an even more history-loaded city.
Jordan is a place I love, and again, there is a broad range of things to do there, lots and lots of history, Dead Sea spas, scuba diving in the Red Sea, dune bashing and camping in the desert in Wadi Rum. As a group of women you would not be going on raucous nights out here, but I found the Jordanians very respectful people. I travelled here with my mother, just 2 women, and we had no bother at all but we respected local customs.
If none of those suit, give us some more details as to what you want. I could go on about holidays all day!