Makes me sound awful, I know, and I'm not going to be able to start swerving it without upsetting friends, which I'm not going to do. But as appreciative as I am when a friend or relative wants to spend time with me and offers me hospitality, I've come to strongly dislike the actual process of staying in other people's houses for all sorts of reasons:
1: I have a sleep disorder which can keep me awake till up to 3 a.m. (this is in spite of a daily early wake time, I have delayed sleep phase syndrome and it doesn't tend to respond to normal sleep logic as sufferers' body clocks are hardwired differently) which inevitably means I am exhausted on the next day of a stay at someone's house, feel lousy when I wake, and really have to struggle to be sociable and energetic. Daft little things like unfamiliar pillows/mattresses can exacerbate this problem hugely. The problem is also compounded on stays away from home by the fact that DH is a very loud snorer and tends to move around a lot in his sleep - at home we get around this when necessary with separate beds, but can't do this when we're away, obviously.
2: I'm also an introvert, and it's always a tricky balance for me because as much as I love the company of my friends, I also NEED time alone and when people entertain, they seem to feel they're letting their guests down if they don't 'schedule' every single second. DH and I are both quite introverted and give each other the space we need at home, but perhaps I've been 'spoiled' in that regard and turned a bit antisocial, I dunno. But I always end a visit to someone else's house feeling boundless relief that I'm free to be me again. (I accept that my hosts might feel exactly the same way and need their own space too, BTW, but it always seems to be a case of both hosts and guests not wanting to propose some downtime on their own for fear of seeming rude, maybe the British really are too polite for their own good, lol.)
3: Other people's pets trigger off fairly troublesome allergic reactions in me, I love animals and have cats at home (I seem 'acclimatised' to our own cats so the allergy thing is far less of an issue at home) but other people's pets set me off big time, and I don't expect people to shut them away just because I am visiting, so I tend to spend visits with my eyes constantly itching and blowing my nose every five seconds.
4: Other People's Children First Thing In The Morning. I'm just going to leave this one here as I'm sure I don't need to elaborate 
(at least for those of us who struggle to come awake first thing in the morning).
Seriously, when I type this all out I'm aware I come off as an awful person and I'm expecting some flak, but am genuinely curious as to whether it's just me/whether I am really odd or weird to feel this way. I try not to stay at friends' houses if I can avoid it (prefer hotels by far, for the freedom and space), because although I am a good guest (I go to great lengths to mask my real feelings on all of this stuff, lol and I help my hosts out with meal prep etc if they want me to, and am appreciative of everything that's done for me, etc) I feel I shouldn't be taking advantage of their hospitality when deep down I know I'm not liking staying in someone else's house. At the same time I wouldn't want to hurt someone's feelings by refusing a stay in their house.
There isn't really a solution except to accept I'm out of my comfort zone in other people's houses and that it's part of parcel of having friends, which I do, but I'm genuinely curious as to whether other people feel any of this from time to time? I think I'm a bit of an unusual mix as although I'm introverted and solitary, I do love socialising in small doses and deeply value my friends, I just can't be around others, or in someone else's domestic set,-up 24/7 without getting very stressed.