Has anyone had two trisomy pregnancies?

[VioletteValentia]

I’ve just had my results today from my pregnancy tissue testing. I had a girl who miscarried due to an extra copy of chromosome 9, which is fatal. I also have antiphospholipid antibodies.

This pregnancy was almost identical to a previous loss, which I had no testing on. I had slow growth and low HCG which I’ve been told may point to a trisomy, but we won’t know for sure. It could’ve also been the antiphospholipid.

Now, what I want to know is, why would I possibly have a trisomy twice? Does this mean I’m more likely to have another? Has this happened to anyone else? Posting here for traffic because I’m sure someone out there has had this happen.

I'm not an expert but as I understand it, full trisomy 9 is usually not hereditary, but it is common, so the chances are it was just bad luck.

Are you getting karyotyping done on yourself? That will tell you for sure whether it was coincidence. The NHS will usually only do karyotyping after a third miscarriage (although they usually only do tissue testing on the baby after the third miscarriage as well). Alternatively you can get all the tests done privately for about 800 pounds.

It's a difficult call. I chose to wait for the NHS and then found out I had a translocation (so I had 3 miscarriages with aneuploidy at 13/14) and I wish I'd just had the testing after the first MC, might have felt different if they'd come up a blank though.

I'm sorry for your loss

Yes we are having karyotyping. They took bloods today, this is our third loss, but our second loss was a natural miscarriage and completely different. These two required surgical treatment.

Sorry also it’s a horrible thing.

If there is anything amiss with either you or your DH, they'll refer you to a genetic counsellor and they'll explain the implications. It's not a lot of comfort but at least now things will start to move.

My understanding is that chromosome disorders can either be inherited from a parent of the parent carries it they have a 50% chance of passing it on or de novo ? Ds has a chromosome deletion both myself have been tested and neither of us carry it so ds is de novo .

If not of .

They’re testing us to see if we carry anything. It just seems strange we had pregnancies so similar, eerily i felt like I was repeating the first, which is why I wonder if the first baby also had this.