I have been in both situations so this is just my opinion but..
Job 1 - very high stress, medium paid, lots of responsibility. Company culture was awful and my boss was not able to cope hence I ended up doing lots in the evening and weekends. I was expected to be available at all times. What made it stressful for me was the uncertainty, never knowing if I would still have a job week to week because the culture was so bad and often people were being cut for minor things. A very political and back stabbing organisation.
In that situation my home life suffered as I was always distracted and worrying about work.
Job 2 (current job) - higher pay, more responsibility and pressure to achieve. Much less stress. The main reason being that I have more control over my own team and work. I am expected to be available if needed out of hours but its not constant. I have a capable director who is supportive and the pressure encourages me to do better rather than to panic and feel stressed.
So I guess I would say yes it is possible but the difference is in the working environment and also how you categorise pressure and stress. I cope well with pressure but stress is a killer.
However with any relatively high earning / responsible job you have to accept that there isn't really a 9-5. Although my work/life balance is much improved and I am happy with it, I do check emails on holidays and make sure I am available as that just comes with the wage.
For me its more about separating mentally work from home and I am now in a place where I can do that so I am not distracted at home in the evenings or when I'm with my kids.
not sure if that is helpful or not !