I'm 42 and have noticed that every month mid cycle (so around ovulation time), my mood dips to such a low level that I feel incredibly depressed and want to quit everything (marriage, job, etc). It used to only last a couple of days, but this month I am only just coming out of it after nearly a week. This is having a major impact on my life, affecting a number of relationships. My doctor has tried me on antidepressants in the past, but to be honest, they didn't help so I came off them a few years ago. Anyone any ideas of what I can try? I have joined a gym and I enjoy it , but I think this issue is hormonal so it hasn't really helped much. 