To think Macduff was born from a woman who had a C section

[armpitz]

Which is hardly the same as not being born from a woman?

What the chuff does Macbeth mean then ?

Have always wondered.

Yes, obviously the caesarean means that he was not 'born', or perhaps birthed, in the usual way. Women did not survive caesareans.

Absolutely nothing to do with gender.

You're looking for sense in Shakespeare? 'That way madness lies'. Ha, see what I did there?