I live in a very famous city in the north. (Comes up regularly on the "Where do you dream of living" polls on mumsnet.)
Jobs are fairly plentiful here and not to seasonal (as tourists want to come here in the winter too! They undoubtedly don't pay as much as, say, London though. (My own profession (finance related) I suspect I could get between 50% and 100% more if I worked in London, Dh (IT) probably closer to the 50% more.)
I've just done a rightmove search.
1 shared ownership for £65k. (Not sure if anyone can buy this or if you have to be a particular occupation such as a nurse.)
Several (admittedly rather grotty looking) studios for £80k - £100k.
£390k would buy you a 4 bed detached in a nice part of the city.
I have several friends who are now "stuck" in London as they moved there "for a couple of years" post university, got jobs, specialised, met someone, got married and now either they or their husband's job can't be done outside London.
Will be advising my kids to avoid London at all costs! (Although can't imagine they would want to go when they already live in the most beautiful city in the country!
)