Background- I have a kidney infection, had antibiotics on Wednesday, came up in itchy nettle rash type rash on my upper back the next day, GP thought maybe reaction to the antibiotic (Macrodantin) so gave me a different one from a different family (Cefaclor). I had one dose that night, two yesterday, and then another this morning. About two or three hours later rash came back on my back, but worse, hotter and more itchy.I started to cough, which at that point I didn't connect with the rash. I called DH to say I needed to go to the out of hours GP, left message on his mobile as he'd taken the girls out, then called a friend to ask her to come over and my lips started tingling, face tingling, eyes etc, so called an ambulance as tongue felt strange. The operator told me to use my epipen but I was too scared (have one for wasp stings but have never used it) was in a complete panic. Ambulance men came and i took some piriton, and they took me to A+E. Anyway in A+E I was better, tingling had stopped, so they have sent me home with more piriton and a new antibiotic (trimethoprim). Am TERRIFIED of taking it. Still have pain in my kidney so I think I do need it. Any experience of antibiotic reactions? Are you ok with some but not others? I've had plenty and not reacted at all so this is a real shock. I can't see any other link in the ingredients between the two drugs, only titanium dioxide and talc, both of those are pretty intert. don't know if its something unconnected even. Really scared. The hospital is an hours drive away which doesn't help.