I had a permanent academic position in the life sciences and moved to secondary teaching and now I run a private tuition business (earning similar amounts to dh who is a SL also in the life sciences).
I loved science during my degree, loved research during my PhD, loved it even more during my (overseas presitigious) postdoc, slightly less so during my temporary dalliance with contract research and then I got offered a permanent academic position in the UK. Sounded wonderful. Build my own research group? Yeah, great! Teach highly motivated undergrads? Wonderful!
In reality, I realised that you are building your research group, which means you are stuck behind a desk writting grants to get funding for students/post-docs to do the research you would like to do yourself (and could do quicker and better yourself). Teaching in HE is a fairly thankless task. Most people don't get promoted on the basis of being good teachers, you get promoted on the basis of research funding attracted, so more sitting behind a desk writting grants (and those research papers your PhD students couldn't be bothered to finish off). There's an awful lot of isoolated sitting behind a desk. Yes, you get to go on conferences, but in my ex-department, only if you have personally applied for funding to do so.
I don't do research any more, but I'm still on the editorial boards of 4 international peer-reviewed journals. I do get pee'd off with the same old shit being repeated again and again. Most scientfic research is not about scientists making massively ground-breaking decisions, but is scientists getting any old crap published to support their latest grant application.
Sorry, that's very negative, but I suspect the grass is always greener. Oh and btw, as a lecturer, there wasn't a single family holiday where I didn't take work with me (and complete it) whilst on holiday. I also routinely worked until 34am and got up to be in the office at 9am. I was writting papers whilst in hospital awaiting the birth of ds1, answering reviewers comments on a grant application 2 days after the birth of ds2 and back in woork for meetin with my research group with 6 weeks of ds2 birth (unpaid). In the sciences, it is not a career compatible with young families.