I have no words of wisdom on being perimenopausal (I have that to look forward to...), but I've been there on sick leave due to stress, I've retrained, moved far away, and started a new job a couple of times so far.
Moving is always stressful. Do your absolute best to minimise the stress, whether that's decluttering or just labelling boxes with room names, so that they all go to the right place.
Once you have moved and you're settled in, try to get involved in your local area, and to get to know people, even if it's just chatting with the neighbours to start with. Go to an activity of interest, church, or whatever your thing is. Even getting your nails or eyebrows done could be a thing; beauticians know an awful lot about the lives of their clients, and might put you on the right track for things to do, and you might find people in common. At least those activities usually end at a set time, so it's not quite as overwhelming as being there full-time. Just remember that you don't have to cram every waking moment with a 'thing'; it's fine to relax.
Go out in your new area, travel and find your way around, eat out, visit festivals or local celebrations if you can (I have to avoid busy periods and places, as they are too overwhelming for me, personally!). That way, you might find things in common with people at work/in the area. If you move to a place where English isn't the dominant language, (1) learn the words and phrases that signify that you have manners in the local language, and (2) sign up for language classes ASAP, and start watching children's TV and reading picture books in that language. That way, you can pick up bits, recognise them, and perhaps, eventually, you might be brave enough to carry a simple conversation out.
If you have a sociable dog, you will find that you meet a LOT of people through daily walks. (Mine are endlessly sociable, whereas I am a bit shy with new people, so I've had to spend a lot of time chatting with other dog-walkers!).
Other than that, good luck, OP! I only moved 80 miles away, but it might as well be another world at times, and I much prefer it here 😊