I worked in Southampton and now live in the Midlands. Honestly if we didn't have relatives to be near we'd move much further north.
Southampton puts you in the right place centrally for a wonderful coastline but also giving you the city aspect. However I found it a PITA to get around in rush hour and the housing stock is very similar within the city borders (Post second World war terraced) and it felt claustrophobic to me.
Whilst I miss living there in some respects living in a city with big pollution problems nah I'd happily go north nowadays just not to be so hemmed in.
ETA: we went from a 3 bed new build terraced townhouse in the suburbs just over the Hamble River to a 4 bed semi detached house with room to extend for the same price in the Midlands.