I have never applied for a job that required 'essential' qualifications I didn't have because I'm scared of rejection out of my own stupidity for not listening to the requirements and wasting everyone's time. I will apply if they are 'nice to have' but never if they are listen as essential. If i am working towards the qualification of missing a bit of the experience length I would apply. But completely no relevant qualifications or experience to requirement? Noway.
I have taken jobs that I wasn't qualified for because they were offered to me and I was assured there would be training.
Usually the employer is desperate eg mat cover that nobody wants, high turn over shitty jobs, employer not paying enough for the experienced and qualified staff they really need, employer too busy to go through the advertising and hiring process properly.
The training usually doesn't scratch the surface and I quickly realise how out of depth I am, my mental health starts to suffer and I lose confidence and motivation as I make more mistakes and feel like I let everyone down. A month or three later everyone expects me to know my role and get irritated when I ask for help, looking at me like I'm an idiot. I get that in such companies the 'mentor' is probably not paid enough to train and support long enough so they resent the added responsibility to their load. it creates tension when a mistake happens, you're supposedly hired at a certain level but you're asking others sometimes more junior for help. It makes you lose credibility and respect among colleagues like is she a liar? A scammer? Did she get it because she knows someone or because of her looks? The insinuation is that you got the job without merit.
So now I would now neither apply nor take out of depth jobs.. however, plenty of people are on the opposite spectrum to me, they havr misplaced high self confidence, maybe a touch of narcissism, they think they are so marvellous and brilliant even when they are the biggest bullshitters. They talk the talk, they know how to charm people and they get places that on paper they have very little qualifications for.
So my opinion is, if you have high self confidence and thick skin go for it. If you are sensitive, if you care too much about doing a job well, if the consequences of a mistakr on the job is too high like people dying or losing money then I wouldn't recommend it.
I know they say men go for high jobs anyway but they also tend to be more stressed at work and generally do a lot less at home than women. Life home balance and support at home is something to think about when aiming for jobs that will be strerching you at least for the first 6 months while you learn to make up for the qualifications shortfall.