Methotrexate

[pinkpeoniesmakemesmile]

Looking for positive stories from those on Methotrexate for multiple autoimmune diseases.
I'm due to start it next week and feeling pretty apprehensive.

Started in January for psoriatic arthritis. Was rough at first, lot of side effects and blood tests every two weeks for liver damage.

But after about six weeks it started to work and the side effects went down to manageable. Liver fine and blood test frequency now reduced.

It's still a bit shit having to take something you feel might be toxic and I do still get 'meth' days but it does actually work and I'm mostly pain free most of the time which is amazing.

If it doesn't work for you there are other treatments - the hardest thing is the slow start to feeling better.

You might want to re-post under the ‘autoimmune disease’ topic as that may get seen by more MNers with relevant experience.
Similarly, it would be worth you checking out the autoimmune board for other posts discussing MTX:
https://www.mumsnet.com/talk/autoimmune_disease

I've been on 25mg for ten years now. Hate the trackers honestly no side effects that I notice from the injection. I take it at night. I wouldn't be able to walk without it. (Plus biologic plus sulfasalazine plus naproxen plus painkillers). But I have pretty intractable psoriatic arthritis and or ankles ing spondylitis with all the lovely extras

Someday I'll speak check. I hated the tablets

I took methotrexate for my psoriasis. It was life changing. I had to stop because my blood cell count deteriorated. I wish it hadn’t.

Please make sure you're drinking plenty of water - a relative has kidney damage from being on this drug and not drinking enough

First time DH was on it for less than a year, 2nd time around 5 years for PA as well. Currently not on it and doing well.

He would feel crap a couple of days, better a few days then needing to take it again.
Better than not being on it!

Has a friend that ended up on the most expensive biologicals going, most expensive patient in the GP practice 😳

I take it, alongside prednisolone, for polymyalgia. Have been lucky enough to have no obvious side effects, but that may be because they are counteracted by all the additional medication I take for the side effects from prednisolone.