Hi OP, I suffered severe fatigue for about 5 years. I tried so many things. the most helpful were:
Vitamin D spray
Feroglobin or Floradix liquid iron
L-Tyrosine
Vit B supplements
Drink 2 litres of water every day.
In terms of keeping up with housework - the 5-minute 'room rescue' from Flylady's cleaning system is wonderful.
Set a timer for 5 minutes. In that time, do as much as you can to make a room look presentable. Do big, visibly ugly stuff first, like empty overflowing bins, hanging up coats and bags, pairing shoes, chucking newspapers and junk mail.
If it's the kitchen, empty and reload dishwasher and wipe down surfaces.
If the living room, plump up cushions, clear away dirty mugs and stray clothes etc.
If the bathroom, wipe mirrors and taps, hang up or change towels and bathmats and clean the loo.
The uplift you get from how much better the house looks after just 5 minutes' effort is a real incentive.
I used 5 minute sessions to:
put on a laundry load
take one out and dry it
fold it
unload and reload the dishwasher
tidy a room
clear and lay the kitchen table
clean kitchen surfaces and sink
declutter the hall
It all adds up but it's never overwhelming.
As you home-ed, you have extra clutter and mess as you are all in the house all day long. But you also have extra helpers. Getting DC into the habit of picking up after themselves is really important.
Get your DC to do room rescues too. Count how many toys you can put away in 5 minutes. Get them to do one job at a time; put books away or check with floordrobe clothes are clean and which are dirty 
. Sort washing piles into whites, lights and darks. Etc.
I made cleaning fun. We'd put on a loud pop song and one would have a feather duster, another would have a cloth and spray and they would do what they could in 5 mins. You can get rid of a lot of dust and cobwebs with two energetic DC in 5 mins. Same with vacuuming. Get DC to do 5 mins - main traffic areas of living room (not a deep clean under furniture) or half way up the stairs. Then the other Dc can do half way down the stairs (if they are old enough and strong enough.)
You get the picture. Do nothing for more than 5 mins. You get loads done in 5 mins. Get DC to help. Make it fun.
keep cooking easy. Tray bakes or single pot recipes. Have a couple of nights a week of ready meals or straight from freezer to oven stuff.
Book a cleaner to do deep cleaning a few times a year.