I've kept them for years without a lot of the issues posted on this thread.
Hutch- most shop bought ones are not big enough for lops so I would get smaller species. Even then they aren't ideal. The hutches with doors at the bottom can be adapted by attaching a run on. Mine always had outside space and I put an old cold frame in there with a box of soil. They loved sitting in the soil and sunbathing. Hutches are my biggest bug for rabbits, they need space to hop. The biggest annoyance is people who sell guinea Pig hutches for rabbits, where they don't have room to hop.
Run- yes needed. A decent sized so they can run and jump. They do like to dig though so don't go out and leave them in it!
Get them neutered/spayed to improve health and temperament (around £80 per pet). I had a bastard of a rabbit years ago who was like a guard dog. He wasn't neutered...it really makes a difference when they are!! Makes sure you get them out every night for a cuddle to tame them.
Lots of straw and the plain nuggets to eat (used to buy huge bags etc so about £15 a month on food). Don't get the muesli as they tend to leave the bits that are good for them! Not too many carrots...carrots are a rare treat. I'm shocked at how much some posters spend on food on here! My rabbits had a bowl of nuggets between them a day and a tonne of straw and were perfect weight so I wasn't underfeeding them.
They don't need to come in over winter, just make sure you can cover windows etc. I used old carpet and shut them up at night. Hutch is somewhere sheltered in the garden. On really cold nights we would fill a bottle with warm water for them to cuddle up to. They mainly were ok as long as they had a huge amount of straw to snuggle into. I used to bring them into the house for a hop about in the winter too, just keep an eye on their chewing.
Vets bills - well, I wouldn't spend thousands. I am a realistic animal owner. As with any animal, you can spend thousands if you want. Rabbits can be sickly and have a fair bit wrong so you need to weigh that up. I'm sure many people will take issue with that but you need to know when to stop.
Vaccinations - about £80 a year each for them. Our vet used to do a health check and trim their nails etc. No issues with teeth. They need stuff to gnaw on.
Holidays: we used to put ours in our local pet hotel for £5 a night. No issues there.
Cleaning out- I had to do it every other day as they pooed a ridiculous amount.
My daughter absolutely adored our rabbits. They were amazing and lasted 7years. I was devastated when they died and haven't had rabbits for 2 years now. I really miss them though and am now weighing up buying some more. I need to buy a new hutch though as the last one was purpose built for them and it is hard to find anything that is as good for space.
One last thing - I always chose the rabbit who was the most inquisitive, regardless of colour. A rabbit should be curious and I believe it's a sign of their health! And I would never keep a rabbit alone. I tried to match our widowed male with a new lady friend and it didn't work out sadly. He was mourned the loss so very badly and went downhill quickly. So you have to be prepared for when one dies.
Adore rabbits! Not easy peasy pets but so rewarding.