I can think of a few who went past the ten thousand mark. I have grouped them into categories.
1)Fund raising in memorium of a child, to raise a fund to help children/families in a similar place in the future. Always been the extended family and community, not just an individual parent. Totally heart rending stories that would make a complete stranger cry. Usually people can see how that could be them/their child. Tends to be partially going towards local hospital, so makes a connection.
2)Fund raising in gratitude for the near-miraculous survival of a child, who needed very high levels of medical input. Again, always the extended family, community, and in the most successful instance I can think of the family business. Again, totally heart rending "there but for the grace of god" stories. Again, raising towards health services that people could imagine using.
3)Next example is on a national level. Raised over 100,000. But started as awareness campaign, that turned into money raising. Personable lead dealing amazingly with impending death. Started out raising awareness of a generic issue to fellow doctors, really online media savvy, generated national campaign, and awards, and blogs/twitters/books. Made everyone think "wow they're awesome" and "that would help everyone" and "gosh, you made me think".
4)Instead of fundraising went back to work and did overtime, then donated any spare money she'd earned. Some colleagues chipped in, without being asked, when they realised what she was doing.
The problem you're up against is that you're not a cute kid. You're not (I sincerely hope!) valiantly facing an early death. You're probably not talking about a condition that everyone is going to think "shit, that could be me". Most people have a relatively small circle of friends/colleagues/associates. Most people will be prepared to donate once. More than that gets trickier.