I have been lucky enough to visit Italy many many times over the past 25 years, a combination of work / pleasure.
I can still remember my very first trip as a young university student, we went to Florence and I literally could not believe the place - it had a profound affect on me!
My first trip with dh, then bf, was to Italy. I had been 3 times already by then but i KNEW he would be blown away by it too. We flew to Milan , spent 2 days there, then train to Venice - (impossibly romantic and all the more so when you are in love) and then the train to Florence, we also spent a night or two in Arrezzo where Life is Beautiful is filmed.
We loved it all so much that we went back again the following year and spent a week in Rome and then a week driving about Tuscany, staying near Pienza.
Other visits have included Lake Garda, Verona, Sienna, Pisa, and back on an almost annual basis to Venice -which we both adore. In fact we are heading there again in early Summer.
I believe Italy is my spiritual home even though I have no Italian ancestry...
Hope you have a wonderful trip!