Love this question I'll quote from a thing I'm working on at the moment below. I would mainly avoid emulsifiers and low cal sweeteners!"Inevitably, most studies focus on obesity 2,11, but there is also evidence that increased UPF intake is strongly associated with an increased risk of:· death – so called all-cause mortality 12–16· cardiovascular disease (strokes and heart attacks) 14,15,17· cancers (all cancers overall, as well as breast cancer specifically) 18· type two diabetes 19,20· high blood pressure 21–23· fatty liver disease 24· inflammatory bowel disease (ulcerative colitis and Crohn’s disease) 25,26· depression 27· worse blood fat profile 28· frailty (as measured by grip strength) 29,30· irritable bowel syndrome and dyspepsia (indigestion) 28· dementia 31This evidence is robust and importantly it shows that UPF is not simply salty, fatty, sugary food low in fibre."References are here:11. Dicken, S. J. & Batterham, R. L. The Role of Diet Quality in Mediating the Association between Ultra-Processed Food Intake, Obesity and Health-Related Outcomes: A Review of Prospective Cohort Studies. Nutrients 14, (2021).12. Schnabel, L. et al. Association Between Ultraprocessed Food Consumption and Risk of Mortality Among Middle-aged Adults in France. JAMA Intern. Med. 179, 490–498 (2019).13. Rico-Campà, A. et al. Association between consumption of ultra-processed foods and all cause mortality: SUN prospective cohort study. BMJ 365, l1949 (2019).14. Kim, H., Hu, E. A. & Rebholz, C. M. Ultra-processed food intake and mortality in the USA: results from the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994). Public Health Nutr. 22, 1777–1785 (2019).15. Bonaccio, M. et al. Ultra-processed food consumption is associated with increased risk of all-cause and cardiovascular mortality in the Moli-sani Study. Am. J. Clin. Nutr. 113, 446–455 (2021).16. Chen, X. et al. Consumption of ultra-processed foods and health outcomes: a systematic review of epidemiological studies. Nutr. J. 19, 86 (2020).17. Srour, B. et al. Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé). BMJ 365, l1451 (2019).18. Fiolet, T. et al. Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort. BMJ 360, k322 (2018).19. Llavero-Valero, M. et al. Ultra-processed foods and type-2 diabetes risk in the SUN project: A prospective cohort study. Clin. Nutr. 40, 2817–2824 (2021).20. Srour, B. et al. Ultraprocessed Food Consumption and Risk of Type 2 Diabetes Among Participants of the NutriNet-Santé Prospective Cohort. JAMA Intern. Med. 180, 283–291 (2020).21. Jardim, M. Z., Costa, B. V. de L., Pessoa, M. C. & Duarte, C. K. Ultra-processed foods increase noncommunicable chronic disease risk. Nutr. Res. 95, 19–34 (2021).22. Silva Meneguelli, T. et al. Food consumption by degree of processing and cardiometabolic risk: a systematic review. Int. J. Food Sci. Nutr. 71, 678–692 (2020).23. Mendonça, R. de D. et al. Ultra-Processed Food Consumption and the Incidence of Hypertension in a Mediterranean Cohort: The Seguimiento Universidad de Navarra Project. Am. J. Hypertens. 30, 358–366 (2017).24. Zhang, S. et al. Ultra-processed food consumption and the risk of non-alcoholic fatty liver disease in the Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study. Int. J. Epidemiol. 51, 237–249 (2022).25. Narula, N. et al. Association of ultra-processed food intake with risk of inflammatory bowel disease: prospective cohort study. BMJ 374, n1554 (2021).26. Lo, C.-H. et al. Ultra-processed Foods and Risk of Crohn’s Disease and Ulcerative Colitis: A Prospective Cohort Study. Clin. Gastroenterol. Hepatol. 20, e1323–e1337 (2022).27. Gómez-Donoso, C. et al. Ultra-processed food consumption and the incidence of depression in a Mediterranean cohort: the SUN Project. Eur. J. Nutr. 59, 1093–1103 (2020).28. Schnabel, L. et al. Association Between Ultra-Processed Food Consumption and Functional Gastrointestinal Disorders: Results From the French NutriNet-Santé Cohort. Am. J. Gastroenterol. 113, 1217–1228 (2018).29. Mariath, A. B., Machado, A. D., Ferreira, L. do N. M. & Ribeiro, S. M. L. The possible role of increased consumption of ultra-processed food products in the development of frailty: a threat for healthy ageing? Br. J. Nutr. 1–6 (2021).30. Zhang, S. et al. Ultra-processed food intake is associated with grip strength decline in middle-aged and older adults: a prospective analysis of the TCLSIH study. Eur. J. Nutr. 61, 1331–1341 (2022).31. Li, H. et al. Association of Ultraprocessed Food Consumption With Risk of Dementia: A Prospective Cohort. Neurology (2022) doi:10.1212/WNL.0000000000200871.