Do you think I should give up TTC?

Sounds really tough. I don’t have much advice other than are you speaking to someone with counselling?

I would keep trying if you still have the heart or else you may regret giving up later down the line. I echo the previous poster about finding someone professional to talk through your worries.

Keep working towards your goal with getting fitter as in the end it can all help. Wishing you luck. 42/43 is still not old.

If you don't want to give up, can you privately fund IVF? Would you consider the jabs if BMI is the barrier for you? I hope you can get some therapeutic support. Wishing you the best

Unfortunately no one can know if you’ll be able to conceive at your age. Some can. Some can’t. Everyone told me I wasn’t too old at 40 and “plenty of women have babies after 40!!” Which is true they do. But sadly it was too old for me. To be honest though I have no idea if I’d have succeeded earlier because I didn’t try before 40 so I’ll never know. (Met my husband at 39). We started trying the month I turned 40. I had my first miscarriage the month before I turned 41. We started IVF at 41.5. First round failed. Round 2 at 42. Ended in miscarriage. Round 3 at 42.5 failed. Kept “trying” naturally until 43.5 where we agreed to give up. Technically I guess you could say we still “try” because we don’t use contraception. But I’m almost 45 now and nothing so it’s not going to happen now we know that.

If you consider private IVF make sure you go in with your eyes wide open about the actual true statistics for women aged 42/43. They are not good at all. IVF isn’t a miracle cure for age related infertility unfortunately. One possibility is considering donor eggs. We decided it wasn’t for us but the statistics are much better obviously.

I'd focus on getting fitter. Being healthier, not just losing weight. Lots of fresh air & exercise, walking, swimming, dance, gym, whatever you prefer.

Improve the quality of your diet, not just cut calories. Think about a good variety of fruit & veg, good protein, fewer carbs.

If you drink or smoke, stop.

You know you can conceive so have lots of fun with your dh and let nature do the rest. I know it's tough but worrying won't help.

I don't know what you should do but I'm so sorry you're going through this. It must be awful.

It's not settled science at all but there is some indication that exposure to fire retardants in soft furnishings could negatively impact fertility. There were some articles in the Times about it, apparently we add far more than in Europe/USA.
I'm sure you're already eating healthy and getting exercise etc. Another thing that could maybe be worth trying is reducing exposure to industrial chemicals.
Things like microwaving food in a ceramic bowl rather than plastic container, putting a non-flame retardant blanket over the sofa may possibly help. Or may not. I don't think anybody really knows.

I would go privately for some initial testing - that’s not affected by your current BMI. That’ll give you a better picture of your situation and whether IVF would likely be successful or not, whether that’s pursuing it privately or via NHS when you’ve lowered your BMI.

I'm sorry to read your post OP. You sound sad and lost. To be completely honest, your best chance of having a baby is to fund private IVF and use donor eggs rather than your own. Is that something you'd consider (and be able to afford)? If not, I guess that in your shoes I would stop TTC but not actually use contraception. So if it happens it happens, but I'd stop tracking your cycle etc as that can be very depressing when it's not working.

Seeing as you've already conceived once, I would definitely keep trying. There is still a fair chance at your age and I would not let that slip away. I'd try for another 6 months or so and look into private IVF (if you can afford it) after that.

Do you remember what your AMH, FSH and AFC were? As the previous poster said that will give you an idea of your suitability for IVF.

Although what it doesn’t do, and sadly can never do, however is tell you if your eggs are actually good enough to make decent viable embryos.