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Feminism: Sex and gender discussions

Streeting declares the puberty blocker trial 'safe'

577 replies

ArabellaSaurus · 06/01/2026 15:04

https://archive.ph/CFzK4

'On Monday, Mr Streeting reiterated that he was not “comfortable” with the trial, which involves more than 200 people under the age of 16, but said there were significant “checks, balances and safeguards” that made it safe.

He told Sky News: “The thing I’ve had to continually weigh up is that for lots of people who have been through this sort of gender identity treatment, they describe it as life-affirming and life-saving. But there is an understandable degree of public anxiety and concern.

“The crucial reassurance is that not just anyone will be able to sign up to this trial. They will go through extensive assessment by expert clinicians locally that will be reviewed nationally, and every young person would need to assent.
“They’re not old enough to consent. They would need to assent, and they would <a class="break-all" href="https://archive.ph/o/CFzK4/www.telegraph.co.uk/news/2025/12/17/children-cannot-consent-puberty-blocker-trial-wes-streeting/" rel="nofollow" target="_blank">need the consent of parents.

“And so there are lots of checks, balances, oversights and safeguards and constant monitoring in a way that disgracefully wasn’t there before. That’s what gives me the confidence and assurance of knowing this trial is safe.

“There is a debate about whether this is the right thing to do. I understand that, and there’s one thing we’ve learnt about this particular area of policy is that we shouldn’t silence, debate, dissent, disagreement.

“So we’ll continue to have that, and we’ll continue to be subject to scrutiny and challenge.”

Mr Streeting admitted that the children who will be involved in the trial are “very young” and that the drugs are “very strong”.

But he claimed he had tried to take the “politics out of what has been an extremely <a class="break-all" href="https://archive.ph/o/CFzK4/www.telegraph.co.uk/news/2025/11/25/nhs-puberty-blockers-trial-repeat-tavistock-whistleblowers/" rel="nofollow" target="_blank">difficult and sensitive issue”.

Despite the research going ahead, the Health Secretary added: “I think there are still big questions about how we ever ended up in this situation where these sorts of drugs were being routinely prescribed with and we’re continuing to get into that and looking.
“There’ll be another study looking at what’s happened to that cohort of young people over time.”'

OP posts:
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KnottyAuty · 06/03/2026 12:33

J should we hear from the other D's before we hear from C [Jenni Richards KC now on her feet for the MHRA explaining options re discussions between MHRA and KCL on modifying the trial

J the C's have issues with things like the constitution of the research ethics committee JRKC the likely scenario is that whatever the changes are there would be a challenge from C's they are making a "root and branch" challenge to the trial to stop it going ahead

J and you are saying that it's best to wait until the PB trial has been changed and agreed before proceeding with the JR JRKC yes and we say that C's claim is incoherent because they say the only logical response to Jorge's letter is to stop the trial

J if we take this through to July will anything have started in terms of the PB trial JRKC there will have been a further meeting of the research ethics committee. If MHRA and KCLs lead to a revised trial protocol that would come back to us and we would consider it.

JRKC it's my understanding that Mr Sharland's timetable (which we are content with) means that the PB trial would not take place until after judgment in the JR [so - end July]

J C's say relevant approvals have been given unlawfully JRKC they can argue that in July J and by that time no treatment will have been given to anyone in the PB trial before the JR is heard JRKC yes. This court cannot reach a view until hearing the full. C's objection is hollow

J C's don't want an 8 week wait JRKC but its absurd as D's will have to put together their evidence and grounds whilst simultaneously having to work out what the trial is. It could be completely wasted energy if the PB trial doesn't go ahead.

JRKC raises Dr Cass iv in the Observer with her observations on Jorge's letter and her firm view that the trial should proceed. Says C are trying to twist her views. J Dr Cass is not involved in this process tho

JRKC yes - but I am making a point of detail because C's have raised it in their submissions [JRKC sits down. Andrew Sharland KC on his feet] AS reluctantly we don't oppose the stay

[Sharland is counsel for KCL which is an "interested party" in this case] AS our timetable says we make submissions by 27 April, C's can reply, then we get detailed grounds - we don't need a two stage approach given the urgency. in my skeleton we flag up our concerns about

delay in this matter. It's not just about the funding J it's the patients AS yes this is a very "fragile" cohort. "Some are self-medicating with puberty suppressants"... "there's a high level of self-harm - attempted suicide"

KnottyAuty · 06/03/2026 12:38

J so if I've got this right the PB trial won't start... AS the trial is currently paused. Unless it is unpaused it won't happen J will it be AS that's not a matter for me or my client. there won't be recruitment for this trial until this process is over J C's say this is

going to be harmful to people. So nothing is going to be done until this process is over. AS "I don't anticipate any recuirtment to the trial until this case is determined". It's "extremely unlikely" assuming it's done on our timetable and is not punted off into 2027

J if the claim proceeds and is successful nothing will have been done to the participants AS there will be no recruitment to the trial unless this matter is sorted

[Barrister for South Maudsley Hospital Trust (another Interested Party) on her feet saying she supports a stay and Sharland's timetable. The biggest point being that if the PB trial is massively changed or stopped the JR will need to be changed or just falls away]

Angus McCullough KC on his feet for C's AM we need to make clear our position. It is recongised that D has chosen not to withdraw the trial notwithstanding the concerns in Prof Jorge's MHRA letter, but at the very least there should be reconsideration of the fundamentals

AM the idea of just cracking on is not realistic. There has to be a decision which engages with MHRA concerns. J is that right - just looking at the regulatory scheme - the power to approve has already been exercised..

What's being considered now is a discussion which might lead to KCL making an application under reg 24 or MHRA making changes under red 23 - if it's not either of those will there have to be a fresh deicsion AM there will have to be

AM the decision to go ahead in the future is a decision in its own right and susceptible to challenge. It is not possible for the MHRA and KCL to agree to revert to the original trial protocols given the depth of Prof Jorge's concerns

AS funding is not a concern - but presumably whilst the pause is happening there won't be substantial expenditure. The tail should not wag the dog and dictate the timetable. The challenge to the PB trial should be heard as early as possible

J you say there;s going to be a decision, even if it's a do nothing decision, it's still challengeable - doesn't it then follow that your challenge to that will still be live AS yes but the contours will have changed

J yes. They'll make changes and your claim will look different. What I'm trying to understand is why it matters to you that we don't have a rolling JR?

J normally its D who complains about a rolling JR not C AS the practical difficulty is that we're shooting at a moving target - we have what we content is completely inadequate disclosure to understand the decision-making process

KnottyAuty · 06/03/2026 12:49

J how will that be improved by this claim coming to an end and another one starts. They say they'll be giving you disclosure later AS that presupposes there has been co-operation in the pre-action protocol process. We were not given the minutes of the research ethics committee

meetings J yes that's a disclosure application and we can determine that later. What I don't understand is why the stay and then... surely the target is moving atmo and on D's proposal - the target will come to a standstill in 8 weeks time and you can shoot at it

J you'll know what the target is, you'll know what the claim is and then we can see what expert evidence is admissible etc and if there is an issue about disclosure, then we can work that into the timetable. AS there are two concerns

AS one is disclosure - the ability to take shots without a blindfold on and that 2) no one will be recruited by the trial until this is sorted. Mr Sharland stands up to say "determined by the High Court" - we don't want to get into what the Court of Appeal might say

[all parties seem agreed that no recruitment will take place for the PB trial until this claim has been determined in the High Court - so if the JR fails at the High Court and C's appeal - the govt is not agreeing not to recruit for the PB if this JR goes to CoA]

[AS makes more complaints about disclosure] J it's unusual in JR to have a disclosure app before AS producing summary grounds J well certainly detailed grounds. if you want a disclosure application determined maybe we can incorporate that into the timetable.

J and there's the issue of expert evidence being admissible AS there is a fundamental issue on what constitutes a duty of candour and when it is triggered.

[lots of discussion about lack of disclosure - sounds very familiar]

J your worry is that you want enough material to plead a proper case AS exactly J so you're saying when they give you the further decision - you don't just want a one-page letter saying this is the decision you want the underlying reason for it

AS yes J I see Mr Milford [SS] nodding - it may be that you get the reason and some of the underlying documents AS yes J it's in D's interests to give you that as they want to know what your case is about this decision

AS that's the history of this matter which underlies this concern. My lord it is significant to take into account the context. This is a C which involves performing a clinical trial on a highly vulnerable group of people- not just.

because they're children - the court should apply "anxious scrutiny... and that has an impact on the duty of candour" and what was and wasn't considered is very important when it comes to the decision-making process

[reckon the stay will be granted with a disclosure application and possible hearing about admissibility of expert evidence built into the timetable. let's see]

AS our resistance to the stay - 1st is addressed in no recruitment for PB trial untill matters over. 2nd is in relation to disclosure - and there are still issues there

J in this case if there is a timetable and D have to disclose something at a later stage, they might as well disclose it early AS 3rd objection - moving target - if the court can live with a moving target then I think my clients can

J your view is that nothing should be done to this cohort which you describe as vulnerable on the other hand as both interested parties have pointed out there's a need

. to get on with it as D are saying that the trial may well be of benefit to these vulnerable people and the risks faced by these people in the interim.

J you want the matter determined AS we want the matter determined fairly J yes and the disclosure application should do that AS we can debate which way is more efficient - we could have a redetermination on an accelerated timetable, but I'm not pushing back on that aspect

J but you are still opposing AS some of my concerns have been met today J but you are opposing it in principle on the basis we should get on with it [Sharland on his feet]

[says recruitment to the trial will definitely not happen until end July. Can't make any guarantees beyond that] J timetable has been set to get a judgment at end of july but it is a matter for the judge. J okay since your oppo to the stay remains I'll need to give a judgment

[J is doing it in real time] J the C is brought by three C's to challenge regulatory approval in respect of the clinical trial for PB drugs for u18s. The C was filed at begin Feb though there was a slight delay in issuance. Since C has been filed the 2nd defendant - the Sec of

State for Health - but acting through the MHRA sent a letter to the operators of the trial - the interested parties - outlining a number of concerns with the trial. In the light of that letter there are discussions between the interested parties and MHRA

with a view to seeing if these concerns can be met. AM for the claimants says that even if the decision was taken not to make such amendments they can challenge that and it follows there will be a fresh decision in this case. He says the effect of the letter from Prof J in the

MHRA (though he no longer involved) states there were "very serious failings" in the process by which reg approval was given for the trial. He says it is inevitable that a further decision will be made

The Interested Parties are at one in supporting D's application for stay, following discussions over the next 8 weeks will give C the ability to amend their claim. Then a hearing to decide if C's can rely on expert evidence. Then various submissions ending in a 2 day trial

in week commencing 6 July or 3 to 4 days if expert evidence is allowed. I am granting the stay. It is true there is bound to be. a fresh decision. The contours of the litigation are likely to change or at least a strong possibility. There is no point in proceeding with a process

TheywontletmehavethenameIwant · 06/03/2026 12:50

Thanks for the info, are you typing in real time cos that's phenomenal if you are. 😲

lcakethereforeIam · 06/03/2026 12:53

2nd the thanks.

This made me snigger

There are five people in wigs

My first thought was 'transwomen?', tbh I'm now assuming barristers but I'm still not certain.

KnottyAuty · 06/03/2026 12:57

whereby grounds are submitted and then have to be re-submitted in the light of any changes. This will allow a trial and a judge to give a decision by the end of July. Mr Sharland has undertaken that provided that this court determines the claim by the end of July no

participant will be recruited so no harm which C's say will be caused by the trial will happen. The timetable therefore strikes an appropriate balance between the interested parties in the case. AM raised concern about disclosure...

he invites D and IP therefore if the timetable I have mentioned is ordered to give disclosure at the same time they give notice of any further decisions, both the

underlying reasons behind their decisions as well as the original decision. I encourage both parties to deliver as much disclosure as possible by 27 April. Stay sought by D is granted for a period of 8 weeks. Mr Sharland's timetable will be applied

AM I have not addressed mr sharlands timetable J please do AM we wil co-operate with devising a timetable - we have severe concerns about the realism of the two week period between any further decision being issued on 27 April and the amendment of the claim form and any further

evidence. That will potentially be a big task and will require amendments to the expert report from Prof Baxendale. We can't do this on the hoof J no we need to sort it out today - how long do you think you might need. We normally would get up to 3 months

[sorry - AM said - we normally would get up to 3 months] AM may I take instruction [does so] the proposal i have instructions to make it to extend that date by one week - it'll still be tight, but if we get three weeks, then D gets three weeks

J would that mean that? [Andrew Sharland now making some timetabling points] [The headline point remains that there SHOULD be a decision on the Esses/Bell/Bayswater JR by the end of July. At which point D's guarantee not to recruit children to the trial expires]

[So either there is a decision at end July that the JR fails and the PB blocker trial goes ahead (possibly pending appeal). Or the JR succeeds and the PB trial is canned (possibly pending appeal), or there is no ruling in the JR and the PB trial goes ahead by default, assuming...

.. it hasn't already been binned by agreement between KCL and the MHRA.]

One of the biggest lines to come out of this hearing is the assertion that the children who would be lining up for this trial are already self medicating on puberty blockers.

Next substantive hearing is going to be 22 May when disclosure and expert evidence applications will be heard.

J anything else? AM i have an application for disclosure still open and it remains a relevant and pertinent point to resolve J want me to resolve that now? AM yes

J having now ordered this timetable there is a date whereby they have to give you everything arising out of the 8 week disco process. One way to resolve this is to order them to give you everything they think you should see by April 27. AM can I take instruction

[sorry 15 June] J and so they might as well give you everything by 18 May and you can object to it if you haven't got it on 22 May

AM [takes instruction] on that basis I don't pursue the application now J okay they've heard what you said, they've heard what I said and if there's. dispute AM we've got a mechanism to resolve that J can someone draw up an order SS we're happy to do that

BettyBooper · 06/03/2026 12:58

TheywontletmehavethenameIwant · 06/03/2026 12:50

Thanks for the info, are you typing in real time cos that's phenomenal if you are. 😲

Knotty is copy and pasting Nick Wallis's tweets.

Thanks Knotty!

KnottyAuty · 06/03/2026 12:59

TheywontletmehavethenameIwant · 06/03/2026 12:50

Thanks for the info, are you typing in real time cos that's phenomenal if you are. 😲

LOL no!
The hearing seems to have taken just around 90mins and ended about half an hour ago. So I could copy multiple tweets from NW

BettyBooper · 06/03/2026 13:05

If lots of the potential participants are already taking black market PBs, won't this mess up the findings of the trial anyway? How would they know the 'baseline' of the participants before taking PBs if they're already taking them?

The lack of scientific rigour in the whole thing is bonkers.

OpheliaWitchoftheWoods · 06/03/2026 13:07

That confused me too; surely kids self medicating won't be eligble for the trial? And the repeated no recruiting - I will be staggered from the description of the group they are heavily implying are at risk of harm if not given these blockers, (bias fairly clear) and from the references, if there is not already a pool of kids and parents who have been given the nod and are just waiting for the formalities.

BettyBooper · 06/03/2026 13:10

OpheliaWitchoftheWoods · 06/03/2026 13:07

That confused me too; surely kids self medicating won't be eligble for the trial? And the repeated no recruiting - I will be staggered from the description of the group they are heavily implying are at risk of harm if not given these blockers, (bias fairly clear) and from the references, if there is not already a pool of kids and parents who have been given the nod and are just waiting for the formalities.

Yes there was clear implication that they already have a group ready to go. It feels more like a way to legally give this group the drugs they want rather than any sort of 'trial'.

KnottyAuty · 06/03/2026 13:12

BettyBooper · 06/03/2026 13:10

Yes there was clear implication that they already have a group ready to go. It feels more like a way to legally give this group the drugs they want rather than any sort of 'trial'.

Absolutely sounds like that!

PrettyDamnCosmic · 06/03/2026 13:14

OpheliaWitchoftheWoods · 06/03/2026 13:07

That confused me too; surely kids self medicating won't be eligble for the trial? And the repeated no recruiting - I will be staggered from the description of the group they are heavily implying are at risk of harm if not given these blockers, (bias fairly clear) and from the references, if there is not already a pool of kids and parents who have been given the nod and are just waiting for the formalities.

Self-medicating kids shouldn't be eligible as one arm of the trial has patients waiting 12 months before receiving PBs. That isn't possible if they are already taking PBs. Are patients & their parents going to be truthful & admit to self-medicating with PBs?

BettyBooper · 06/03/2026 13:18

PrettyDamnCosmic · 06/03/2026 13:14

Self-medicating kids shouldn't be eligible as one arm of the trial has patients waiting 12 months before receiving PBs. That isn't possible if they are already taking PBs. Are patients & their parents going to be truthful & admit to self-medicating with PBs?

Great point. And yet they are indeed admitting it. So how are they in the cohort being considered?

in my skeleton we flag up our concerns about
delay in this matter. It's not just about the funding J it's the patients AS yes this is a very "fragile" cohort. "Some are self-medicating with puberty suppressants"... "there's a high level of self-harm - attempted suicide"

PrettyDamnCosmic · 06/03/2026 13:26

BettyBooper · 06/03/2026 13:18

Great point. And yet they are indeed admitting it. So how are they in the cohort being considered?

in my skeleton we flag up our concerns about
delay in this matter. It's not just about the funding J it's the patients AS yes this is a very "fragile" cohort. "Some are self-medicating with puberty suppressants"... "there's a high level of self-harm - attempted suicide"

To confirm they are not self-medicating with PBs they will need to screen for this before admission to the trial. They should be loudly telling potential patients that if they are self-medicating with PBs that this will mean they will not be recruited to the trial.

MyAmpleSheep · 06/03/2026 13:31

BettyBooper · 06/03/2026 13:18

Great point. And yet they are indeed admitting it. So how are they in the cohort being considered?

in my skeleton we flag up our concerns about
delay in this matter. It's not just about the funding J it's the patients AS yes this is a very "fragile" cohort. "Some are self-medicating with puberty suppressants"... "there's a high level of self-harm - attempted suicide"

They are in the wider cohort for whose benefit the study is being conducted. The sooner the study is done, the sooner the lessons of the benefits or absence thereof of PB drugs can be applied in clinical practice to the wider cohort.

I think that's the argument.

spannasaurus · 06/03/2026 13:40

The trial protocol does say that anyone who is taking, or has taken, puberty blockers or cross sex hormones is excluded from the trial

https://www.kcl.ac.uk/ioppn/assets/pathways/trial/pathways-trial-protocol.pdf

https://www.kcl.ac.uk/ioppn/assets/pathways/trial/pathways-trial-protocol.pdf

BonfireLady · 06/03/2026 14:03

Thank you for the transcript Knotty.

Now that we know the outcome (stay granted for 8 weeks.... apologies to those who are reading along and didn't yet know the ending!), this bit seems particularly pertinent (bolding is mine):

SS - the MHRA has the power to impose them. We're not sure what route will be taken, but it will take 8 weeks J what will have happened by the end of the 8 week period

SS all the proposed changes will be done - so either a changed protocol, no change to the trial protocol or no protocol at all [and therefore no trial] as one can't be agreed. J C's say that if you look at the MHRA letter from Prof Jorge is that you have already capitulated

It seems like this judge has them on a tight leash. They have said they need 8 weeks to conclude what they want to do and the judge has said the JR can begin again in 8 weeks.

Also, they aren't allowed to start the recruitment process for participants until 8 weeks is over.

In other words, they've got 8 weeks to learn how science works. If they actually understand it, the only logical conclusion they can reach is that this trial is unethical and needs to be cancelled. And if they still can't understand science and/or can't conclude that, a JR will expose all of their decision-making.

They are on the back foot and they know it. Whether they cancel the trial or not, its going to take some incredible PR spin to stop the whole house of cards from falling.

PrettyDamnCosmic · 06/03/2026 14:38

spannasaurus · 06/03/2026 13:40

The trial protocol does say that anyone who is taking, or has taken, puberty blockers or cross sex hormones is excluded from the trial

https://www.kcl.ac.uk/ioppn/assets/pathways/trial/pathways-trial-protocol.pdf

Excellent! This is as it should be but it still means that they should screen the trial participants for PBs & cross-sex hormones before they can be enrolled into the trial.

OpheliaWitchoftheWoods · 06/03/2026 16:48

spannasaurus · 06/03/2026 13:40

The trial protocol does say that anyone who is taking, or has taken, puberty blockers or cross sex hormones is excluded from the trial

https://www.kcl.ac.uk/ioppn/assets/pathways/trial/pathways-trial-protocol.pdf

I wonder how rigorous this will be. There should be blood/hair tests to establish what chemicals are in the system as dishonesty aka 'stealthing' seems to be hard wired into gender ideology.

I was not at all impressed with the whole 'we have to quickly get to handing out the medications or we'll lose them' schtik, it was heavily and obviously biased towards the meds being the answer to meet emotional and mental health issues and 'better a live son' type thinking focused on galloping on to the desired outcome rather than an unbiased experiment on children to see whether these meds are safe.

Ereshkigalangcleg · 08/03/2026 13:31

PrettyDamnCosmic · 06/03/2026 13:14

Self-medicating kids shouldn't be eligible as one arm of the trial has patients waiting 12 months before receiving PBs. That isn't possible if they are already taking PBs. Are patients & their parents going to be truthful & admit to self-medicating with PBs?

We know this group feels entitled to lie and break the rules. There will need to be robust safeguards against this. Less taking on trust than other research.

Imnobody4 · 23/03/2026 20:15

Glad to hear it, about time professionals took back control.

DrBlackbird · 23/03/2026 23:14

What a strange world we live in when this biological sex “is not a matter of belief, but a fundamental physiological variable” somehow becomes a controversial statement.

OpheliaWitchoftheWoods · 24/03/2026 09:13

Quite. I often think we need to go back to 2012 and re set. Something went very wrong around that time.