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The People In The Trees by Hanya Yanagihara
This is going to be quite hard to review I think, but bare with me.
The beginning of the novel introduces us to Ron Kubodera, a scientist, who has chosen to stand by his colleague Norton Perina, a once Nobel Prize winner now convicted paedophile serving time.
Kubodera presents us with Perina's autobiography, sent to him in installments from prison. Kubodera adds a set of footnotes, a fiction within a fiction. There was a lot I thought of Nabokov in the air. I ignored the footnotes and didn't think, on a skim, at the end, they added much, but regretted not realising they formed part of it before finishing. 
The bulk of the novel is about Perina's career which begins when he is selected to go as the team doctor on an anthropological trip to a Micronesian island. Perina makes an important scientific discovery, but all it achieves is destruction and ruin.
Essentially this book is a general commentary on how predominantly white Westerners travel to exotic lands only to remove or destroy anything of beauty or value in the natural world, whilst also destroying the culture of the indigenous peoples. Such stories have indeed been done before, but this is a good one.
I just, from even the earliest pages, found this so engrossing. I was immersed in it, and I've read it in two days. The prose is great, and this is certainly my first bold this year.
Yet, though I don't particularly agree with books needing trigger warnings; I do feel that it would be remiss of me to enthuse about how "good" a book is, when there are many challenging elements for which to use the word "enjoy" in relation to the book would be wrong.
It's got strong literary merit, but is by no means light.
There are examples of abuse to animals, in the form of animal testing
Abuse of indigenous persons as guinea pigs
There are a number of examples of child sexual abuse
If you have the stomach for that content, then do proceed.
If not I'm happy to have given fair warning.
There is a postscript which is both a complete surprise and no surprise at all.
I also loved A Little Life and so will definitely be seeking out To Paradise when it comes down a bit in price.