I was thinking of an mood more like District 9 on that one
Now for something that 'feels' a bit like The Fifth Element, how about this flick plot...
too-near future when most everyone lives in densely packed urban centres. PPL have to be tested daily before they can leave their homes because of circulating plague(s) that have stymied humanity for many decades. Limited resources but communist style society where everyone lives in small basic spaces, has basic needs met. Temperature checks at buildings and lots of 'have to ask permission' rules, like when to start a family due to scarce resources. There are occasional lockdowns because Plague is rife but then lifted again for long spells when people can see others 'normally'. Every institution and activity has constantly changing social contact rules. Life in countryside is much less constrained but food supply in danger because country life allows more contact with others & plague-prone animals. Agricultural workers get the Plague more often which disrupts food supply.
Sporadically there are mini outbreaks of the Plague which kills someone & govt promotes widely accepted message that it's usually the fault of those who get Plague that they didn't follow all the precautions. Lots of rules. Just follow the social contact rules & you'll be fine.
Crazy menacing old bag lady on streets (played by very scruffy BetteDavis type, about 70yo) opens first scene with rantings about "They aren't telling you the truth" which our hero (someone like Will Smith, but 25 years younger) throws coins at coz he's the only person not scared of her. There aren't many elderly people around because they seem to keep dying because of plague, so young people are openly afraid of the elderly in this society NotWillSmith is off to see his girlfriend (played by someone like Halle Berry, but 25 yrs younger). We see their cozy relationship and lots of govt virus control rules they live under. Not-WillSmith has a group of buddies at his work (something that feels working class but is actually high tech, probably involving digital communication network maintenance).
Work buddies include actors played by Daniel Kaluuya, someone like Michael Keaton but 40 yrs younger, and a host of 4-10 others, including someone like EvaMendes but 15 yrs younger.
NotWillSmith sees something weird happen to notHalleBerry but thinks nothing of it. Soon after, Not-HalleBerry gets sick with the plague. In his desperation to help her, notWillSmith goes on a series of adventures eventually discovering that the Plague doesn't exist, it's all govt con to control the population which is still desperately too large for food supplies. People appear to randomly get plague & publicly villified for their carelessness and irresponsibility in catching it, but it's actually a toxin put into them to mimic plague symptoms and there might be a cure. notWillSmith might be able to save notHalleBerry. There is indeed a food supply crisis but this is caused mostly because of environmental pollution having degraded soils not rural workers always getting sick. BetteDavis-like old lady gets dragged around with notWillSmith and his workMateFriends, who are helping NotWillSmith fight the shadowy govt figures and try to expose the huge lies using their working class knowledge of the basics of the digital comms network and how to hack it, find out how info has been manipulated. All the while becoming fugitives and evading authorities and eventually breaking into the home of a politician or journalist believed to be half-sympathetic to revealing the truth about no-actual-plague to the full population.
Politician is very hard nosed, played by Marg Helgenberger and agrees to help the renegades.. but she is soon killed in ambush by shadowy figures. NotMichaelKeaton dies defending notWillSmith (coz the token best friend white guy always dies). Pursuing clues about the assassins leads notWillSmith to find out and confront the ultimate powerful bad guy .. played by MorganFreeman (who doesn't play near enough villains). Thru many little plot twists, bit of techno wizardry, great bravery and ridiculously good luck, notWillSmith, Kaluuya & gang manage to expose Morgan Freeman and the Plague-Myth truth to the entire population.
But will ppl believe the revelations or insist it's all a conspiracy theory? Is next big problem looming.
penultimate scene is notWillSmith getting antidote to notHalleBerry who seems to recover but is weak. Our heros flee to the countryside where they can adopt aliases and plan what to do next. Indeed govt can't track people at all very well in countryside.
Last scene: Kaluuya, notEvaMendes & notWillSmith talk about the challenges ahead, with BetteDavis-clone still doing odd, menacing things in background (she was totally nuts but also saying truth all along). There are a few key plot points where she produces information or skills that helped the group advance their quest... one of the sequels will be her whole backstory and why she was able to live in spite of her dangerous knowledge of the truth -- probably inherent immunity to the toxin which made govt want to study her... maybe harvest her genes to do genetic engineering on the elite class and render them permanently immune to the toxin, too.