Yes we have it in every room, but we have an odd layout (barn conversion) - only one bedroom upstairs. We’re one of 7 Barns all converted by the same builder 10 years ago, our neighbours with more upstairs space have radiators in the upstairs bedrooms and it seems to work for them.
Our system is made by Thermia. The fan unit in the garden is about 1.5m wide 1m deep and maybe 1.2m high. Looks exactly like this: i.ytimg.com/vi/XYklEvEE554/mqdefault.jpg
Sits next to our shed with a bit of trellis in front. I can’t tell you how often the fan kicks in as we can’t hear it inside the house. It’s on sometimes when I leave for work, and well, it sounds like a big fan! It’s not massively noisy, it wouldn't stop you having a conversation next to it, but yes you can hear it - like the sound of air con in an office I guess. In the summer it rarely kicks in, so doesn’t disturb us in the garden. The newer systems have passive cooling, I don’t know the details, but this may cause the fan to run more in summer, maybe something to ask your engineer when they visit?
We have the inside unit in a cupboard in the hall (we don’t have a garage) but our neighbours have it in their attached garage. Again when the heating pump kicks in you can hear it if you are outside the cupboard, but I wouldn’t say it’s any noisier than a standard central heating system.
The biggest downside I think is the servicing. We get ours done every 2 years but you’re limited to a few specialist companies. We found some are reluctant to service units they didn’t install. I think we paid £200 for the last service, so something to factor in.
I’m not sure how it compares efficiency wise to gas - there’s no gas in our village so wasn’t an option for the builders.