on the question of enzymes, which will be denatured by heat...
unless, like me, you have a (rare) hot-fill washing machine, your wash will always start cold. There will be a period, while the heater is working, when the water comes warm but not yet hot enough to stop the enzymes working. With some cool washes it may never get that hot.
If you're doing a maintenenace wash, to remove the sludge which is mostly soap and softener, a hot wash and washing soda will clean it away. I see no point in trying to reduce the soap residue by adding more soap. Give it a hot hot wash with no powder and see if the water goes grey and foam. If it does, that's the soap residue dissolving. Do it again until it stays clear. the washing soda is good for cleaning away soap sludge, and also grease residue.
Liquids seem to lead to sludgier machines, but my opinion is that it's because they are mostly used at lower temperatures.
If you use liquids for delicates and colours, and powder for hot white washes, it seems to me that the machine seems to stay cleaner.
YY to putting the powder or liquid into the drum, it prevents soap sludge and mould in the drawer and its aperture.