I worked in admissions at a decent RG once upon a time, and since have spent 20 years as a university counsellor/advisor/coordinator in schools in the UK and around the world. Now I do it privately.
20ish years ago, there were lists of preferred or facilitating A Level subjects, and a list of 'vocational' or 'less rigorous' subjects, which were to be avoided if aspriations were high, or sometimes one was OK for the top unis if the other 2.5 (in the time of AS levels) were from the preferred list. Business, media, PE, psychology, sociology home languages etc were all on the second list. Those lists were scrapped about 15 years ago, and I've worked with 1000s of students who've gone on to great success at all the RGs, amazing non-RG options, etc with any subject combination, business included. Anyone saying otherwise has old information or, in the uni example above, has a vestige of that policy still at the back of their minds, even if its no longer enforced. Obviously, that doesn't mean that some admissions tutors won't also have that same old fashioned belief however, but this year I've worked with a student taking BM, history and french admitted to HSPS at Cambridge, another with business, maths, FM and geography to LSE, and another with sociology, psychology and history interviewed for law at Oxford (unsuccessful then though).
Proviso- LSE does warn against taking business and economics A Levels due to the overlap. I thought UCL did as well, but can't find it on the website.
What's really interesting is that today, I was checking the updated requirements at Imperial. For many of their engineering courses they now actively promote business, requiring Astar in chemistry, A in maths and A in bio/phys/FM/econ/business studies for chemical engineering for example. Screenshot below. How many students will that rule out because they've been told to do something 'more academic' as their third? Not loads as three sciences is most common for Imperial applicants, but some.
Finally, I wrote this whole comment about A Levels because ultimately, thats what unis care about beyond the already stated maths and English. When it says GCSE profile considered, it means how many 9/8/7/6 etc depending on the uni, and the occasional niche factor like someone taking art, DT, dance, drama and music but then appplying for a demanding STEM course.