I was in exactly this situation at age 35 when I was diagnosed with irreversible sight loss.
After 17 years of driving and 14 years of owning a car I was suddenly unable to drive (as well as, eventually, read and work).
I live in an area with very good bus routes. I get a bus pass because I can’t drive for medical reasons. I rely on taxis/ubers when necessary and I have a supportive family. There’s loads I simply cannot do for myself though. DH has been very supportive. So (now) is DS who can drive and gives me lifts.
I could never move to a rural area. I live on the edge of a town and the idea of moving to the countryside or even abroad fills me with dread. I’m not really a city person, so where I am suits me fine. My world is a lot smaller though.
my kids missed out when they were growing up. They weren’t able to participate in things their friends could because DH works long hours and I couldn’t get them there. However, that’s life. Plenty of kids miss out on things for other reasons.
The saddest part was having to give up work (teaching). Not being able to drive made work very difficult and the eyesight loss eventually made my job impossible.
DH’s parents have recently given up their licenses for no good reason. They believe they can use the money saved to pay for taxis but in the year since selling the car they’ve used precisely zero taxis. If they can’t get there on the bus they don’t go. I am rather irritated by the burden they’ve put on DH who already has enough responsibility being sole breadwinner and helping me out without having to trog halfway around the country to take them to places. That’s just me, though. I’m just a bit intolerant of them and I know that’s my fault.