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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

To ask about Ozempic…..

56 replies

FMLWTF · 18/04/2023 16:47

Ok, hard hat at the ready.

I wondered if anyone had any direct (so not my neighbour’s auntie’s postman) experience with Ozempic? Has anyone taken it and not had weird side-effects? Lost weight easily and feels it was A Good Thing?

If you’ve nothing helpful to say, can I ask that you try a different thread? My reasons for potentially doing this are personal and serious. But hard hat ok anyway as I know some people just won’t be able to resist.

OP posts:
FMLWTF · 18/04/2023 21:03

That article is not saying quite what you’re saying though. It’s saying that patients lost weight on the drug then their appetite returned and they regained weight when they came off it. Presumably that’s because they went back to their old eating habits.

It doesn’t say anything about appetite doubling (unless you meant doubling from when they were on the drug?) based on their pre-Ozempic appetite. I would expect one’s appetite to return afterwards. It’s not a magic trick is it? But I think you’re fearmongering a bit.

OP posts:
YunaBalloon · 18/04/2023 21:13

Yeah, I think Green is fear mongering a bit too. I've done a significant amount of research in to semaglutide (I work in the NHS so used our medical library) and yes, your appetite will come back, but it will be much the same as before.

For me, it totally cut food noise. So I just don't think about food like I used to. Previously my appetite was virtually insatiable. I couldn't stop eating, I was constantly hungry and never felt full. I'd tried every diet and lifestyle change possible and none were sustainable. And that's the key -sustainable change. But sustainable change is really really hard if food is your foremost thought all the time and absolutely no eating plan/diet changed that. Some ways of eating do work for some people to stop the insatiable appetite but they didn't for me. Ozempic has been like an off switch for me. I just feel really really normal around food. I can listen to my body about what it needs. I can have a biscuit and not scoff the packet. I've no fear that once I start eating I won't stop.

BUT I feel almost constantly sick or have bad indigestion or have really dreadful sulphur burps. It got me down a bit in the last couple of weeks but it's been better today and overall the positives outweigh the negatives.

Twiglets1 · 18/04/2023 21:28

I think what @greenspaces4peace meant was that you will have a strong appetite after stopping Ozempic, which was my experience though I only took it for 6 weeks.
I felt hungrier than normal when I stopped and certain foods that I had not been able to eat on Ozempic due to nausea tasted extra delicious. It’s a shame but it is really hard to keep the weight off when you no longer have the appetite suppression to help you stay on track.
I’m sure some people will succeed and I wish them well, but it’s also good to be aware that lots of people will probably put the weight back on unless they take it for life. It’s not a magic pill, or rather injection, but I guess that’s the case with every method of weight loss.

FMLWTF · 18/04/2023 21:38

Ok, but what they’re saying in that article is not surprising to me, it’s what I would expect to happen once you stop doing the thing that helped you lose weight and return to “normal”. It’s like any diet. It only work long-term if you make permanent changes. If you go back to how you ate before, you’ll gain weight. It’s obvious isn’t it? Still I think for many people the loss itself would be motivation enough to try to keep it off.

OP posts:
Twiglets1 · 18/04/2023 21:42

FMLWTF · 18/04/2023 21:38

Ok, but what they’re saying in that article is not surprising to me, it’s what I would expect to happen once you stop doing the thing that helped you lose weight and return to “normal”. It’s like any diet. It only work long-term if you make permanent changes. If you go back to how you ate before, you’ll gain weight. It’s obvious isn’t it? Still I think for many people the loss itself would be motivation enough to try to keep it off.

The loss itself will be motivation to try to keep it off, I agree. But isn’t that the case with any diet? No one who had lost 2/3 stones for example wants to put it back on, and yet most people do when they stop the diet.

MatchaTea · 18/04/2023 21:47

You need to seriously consider the after-Ozempic. Despite the continued lifestyle interventions, the vast majority of users will regain the weight and return to their abnormal metabolic features. You are mistaken if you think they regained because they returned to bad habits.
It is not true they gained twice as much, but they regain very quickly compared to the weight loss.

In conclusion, among adults with overweight/obesity, after a substantial reduction in body weight during 68 weeks of treatment with once‐weekly s.c. semaglutide plus lifestyle intervention, subsequent treatment withdrawal led to most of the weight loss being regained within 1 year, and a similar change in some cardiometabolic variables back to baseline, reinforcing the need for continued treatment to maintain weight loss and cardiometabolic benefit
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542252/

@FMLWTF unless there is a health threat and you need to put metabolic markers out of danger zone, you might be worse off after ozempic.

Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension

To explore changes in body weight and cardiometabolic risk factors after treatment withdrawal in the STEP 1 trial extension.STEP 1 () randomized 1961 adults with a body mass index ≥ 30 kg/m[2] (or ≥ 27 kg/m[2] ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542252

Twiglets1 · 18/04/2023 21:48

Anyway, YANBU to try Ozempic and there are lots of people talking about it positively on the weight loss forum.
I would still be on it myself if I hadn’t had bad side effects so I’m not against it. I just think people should go in with their eyes open as to what is quite likely to happen when they stop taking it.

ThinWomansBrain · 18/04/2023 21:57

I've been taking the tablets for six monthsish - haven't really lost much weight TBH, but I'm not on the strongest dose, only 7mg - but when I'm eating I do feel full and often leave some - something never heard of before.
Unfortunately I tend to eat because I'm bored/it's there/etc - I never actually feel hungry (I don't think, I'm not entirely sure I'd know what hungry feels like).

You take the tablets in the morning on an empty stomach - occasionally I feel sick for a bit afterwards, but they never actually make me vomit. Haven't really noticed any side effects, aside from more stable blood sugars.

TheCrystalPalace · 18/04/2023 22:07

Where are people getting it from? Someone mentioned getting it privately?
Can you choose between the injection and the tablets?

Twiglets1 · 18/04/2023 22:10

TheCrystalPalace · 18/04/2023 22:07

Where are people getting it from? Someone mentioned getting it privately?
Can you choose between the injection and the tablets?

Most people wanting it for weight loss are getting it privately and buying weekly injections of Ozempic. You can get loads of information if you google it.
Im not sure about the tablets 🤷🏼‍♀️

Greensleevevssnotnose · 18/04/2023 22:18

I take rybselsus the tablet version, I lost 16lb the first month on 3mg and moved to 7mg this week. I have lost 6lb but the heartburn has been awful and I have been sleeping a lot. Have to say I am not looking forward to going up a level again. Have ordered some gaviscon to see if that will help. The weight loss is great and at 3,mg I had no side effects. Not gonna lie this week has been tough.

TheCrystalPalace · 18/04/2023 22:22

Yeah but WHERE? What does "getting it privately" entail?
And how much does it cost?

YunaBalloon · 18/04/2023 22:34

TheCrystalPalace · 18/04/2023 22:22

Yeah but WHERE? What does "getting it privately" entail?
And how much does it cost?

It means getting a private prescription via a consultation with a private GP or prescribing pharmacist. Companies that provide this service include juniper, manual, Numan and quickmeds. The consultation is anything from just a form to a telephone call to a zoom call. It assesses your medical history and whether you meet a criteria for "off label" prescribing, and if you do, they issue and dispense a prescription. It's roughly £150-£200 per month. You'll need to log you starting weight with the prescriber and then again 3months later as there's a criteria for how slow or fast you're allowed to lose weight. You'll get a monthly prescription of a set dose (though in reality months 1 and 2 there's more than a month's dose in the pen). You titrate up from the low dose to the therapeutic dose as per advice from your prescriber. Some [idiots] decide to follow their own titration plans i.e.btaking smaller or bigger doses than advised, but I wouldn't suggest you do that. Most prescribers will do follow up consults/ advice if you need it re side effects, moving doses, if you miss a dose etc.

Kickingupmerrybehaviour · 18/04/2023 22:45

I’ve taken 0.5 mg for a month and haven’t lost so far but have felt sickly and had diarrhoea. I’m due to go up to 1 mg which is the proper dose I believe next week so hoping for some appetite suppressant then. I used to have appetite suppressants years ago that worked well but I think they got withdrawn

TheCrystalPalace · 18/04/2023 22:56

Thank you, @YunaBalloon That's very detailed (although it's not for me, I don't think).

Twiglets1 · 19/04/2023 07:16

TheCrystalPalace · 18/04/2023 22:56

Thank you, @YunaBalloon That's very detailed (although it's not for me, I don't think).

You could have Googled all of that instead of shouting “Yeah but WHERE?” at people on Mumsnet

Laughloveloneliness · 19/04/2023 07:36

I was on an appetite suppressant for a year. It cost me £140 a month (tablets) but was absolutely worth it. It totally switched my relationship with food around. I originally used it to lose weight for a procedure and it is one of the best things I have ever done for myself. I very occasionally felt nauseous for a few minutes an hour or so after taking it but that was all. My habits totally changed and I dont eat anything between meals now. I dont particularly calorie count but don't eat very fatty foods often. It changed my life BUT it is expensive. I sacrificed to pay for it.

Im99912 · 19/04/2023 08:23

The sliming clinic offer ozempic & appetite suppressant
they do on line consultation which consists medical history
they want a photo of your weight - ir you standing on the scales
a video of you taking your blood pressure
a full length selfie
and
the appetite suppressant tablets are about 100 for the month
ozempic not sure

They are a legit company and have been around for at least 20 years

Laughloveloneliness · 19/04/2023 09:20

I will tell you what I did struggle with though at first. Just getting my head around not feeling hungry. It sounds silly but it was really weird. I loved food, I savoured that sandwich I could sit and eat between rushing around at work. I enjoyed making those heavenly Nigella recipes 😊 I just loved good food and it got me down sometimes when I met friends for lunch and I just wasn't hungry. Or thinking about what to cook for tea, DH took over completely for a while. It was worth it though and I still enjoy good food just not as much. I have not lost much since stopping the tablets but I haven't regained either. I've never gone back to the snacking which helps! It just helped me change my mindset.

Greensleevevssnotnose · 19/04/2023 09:42

It is very freeing not needing to eat and the cost is more than offset by not buying food.

Peridot1 · 19/04/2023 12:43

Some interesting viewpoints and experiences on this thread.

I read an interview in the FT a few months ago with the chief executive of the manufacturer and he said that he would expect Ozempic to be a bit like a drug for blood pressure in that you would expect to be on that for life. Obviously he has a vested interest in that outcome. But actually it makes sense. Ozempic is used to treat diabetes. The weight loss is secondary. So to control diabetes you would probably need to take it for life. Unless you reverse your diabetes. Which is possible. But takes a drastic change in diet and weight. Going low carb and losing excess weight has been proven to reverse type 2 diabetes. (Look up Dr David Unwin and look at the free Freshwell app.) But if someone who reversed their diabetes through diet and weight loss went back to eating how they ate before hand they will regain the weight and end up with blood sugar control issues again and become a diabetic again. So if someone who loses weight through using Ozempic stops taking it and goes back to eating the way they ate before they will obviously regain the weight.

I have been taking it for over a year and have lost three stone. It’s been really interesting seeing who it seems to work for and who it doesn’t. It seems to me to possibly work more for people who have blood sugar and insulin issues.

It is not an appetite suppressant per se. That’s a side effect. Obviously Wegovy is not yet available here but as you can take higher doses of that possibly the appetite suppression is much stronger.

In the first article @greenspaces4peace linked to the woman in it went back to eating sugar. Nowhere does it say her appetite doubled. She said she was craving sugar. If she had changed HOW she ate and cut out sugar and reduced carbohydrate intake would she have had the same issue?

In the second article @greenspaces4peace linked to the doctor quoted said you “may” regain weight.

How many of us gained weight by eating high protein and fibre and low carbs with lots of vegetables? Not many I don’t think! But that is how you are advised to eat while taking Ozempic. Most of us put weight on because we eat too much sugary and fatty foods. Processed foods. Treats. And it stands to reason if you revert to eating processed foods and sugar and carbs hey presto you will regain the weight lost. It’s not really rocket science. With the original Atkins diet you go full on low carb until you reach your goal weight. Then you are supposed to gradually reintroduce carbs. Healthy carbs that is. More vegetables and fruit and some wholegrain carbs. Not processed sugary foods and pasta etc. Even with WW and SW when you reach goal they suggest you keep going to meetings to stay on track. I think with WW for instance it’s free once you get to goal but if you lose or gain more than four pounds you start paying again. You are supposed to keep eating the way you ate to lose weight.

We are not supposed to eat a diet high in processed foods and sugary foods and high carbs. We need protein, fibre, vegetables, some fruit and some whole grains.

For me personally I was dieting and getting bigger for 30 years. Ozempic has worked for me. I’ve still got more to lose but I’m getting there. For me I think it was insulin resistance. And if I have to take Ozempic for life along with changing now I eat it’s what I have to do.

But anyone who thinks they can take Ozempic for a few months and lose the weight and then just go back to eating the way they ate before is kidding themselves.

Twiglets1 · 19/04/2023 15:07

Peridot1 · 19/04/2023 12:43

Some interesting viewpoints and experiences on this thread.

I read an interview in the FT a few months ago with the chief executive of the manufacturer and he said that he would expect Ozempic to be a bit like a drug for blood pressure in that you would expect to be on that for life. Obviously he has a vested interest in that outcome. But actually it makes sense. Ozempic is used to treat diabetes. The weight loss is secondary. So to control diabetes you would probably need to take it for life. Unless you reverse your diabetes. Which is possible. But takes a drastic change in diet and weight. Going low carb and losing excess weight has been proven to reverse type 2 diabetes. (Look up Dr David Unwin and look at the free Freshwell app.) But if someone who reversed their diabetes through diet and weight loss went back to eating how they ate before hand they will regain the weight and end up with blood sugar control issues again and become a diabetic again. So if someone who loses weight through using Ozempic stops taking it and goes back to eating the way they ate before they will obviously regain the weight.

I have been taking it for over a year and have lost three stone. It’s been really interesting seeing who it seems to work for and who it doesn’t. It seems to me to possibly work more for people who have blood sugar and insulin issues.

It is not an appetite suppressant per se. That’s a side effect. Obviously Wegovy is not yet available here but as you can take higher doses of that possibly the appetite suppression is much stronger.

In the first article @greenspaces4peace linked to the woman in it went back to eating sugar. Nowhere does it say her appetite doubled. She said she was craving sugar. If she had changed HOW she ate and cut out sugar and reduced carbohydrate intake would she have had the same issue?

In the second article @greenspaces4peace linked to the doctor quoted said you “may” regain weight.

How many of us gained weight by eating high protein and fibre and low carbs with lots of vegetables? Not many I don’t think! But that is how you are advised to eat while taking Ozempic. Most of us put weight on because we eat too much sugary and fatty foods. Processed foods. Treats. And it stands to reason if you revert to eating processed foods and sugar and carbs hey presto you will regain the weight lost. It’s not really rocket science. With the original Atkins diet you go full on low carb until you reach your goal weight. Then you are supposed to gradually reintroduce carbs. Healthy carbs that is. More vegetables and fruit and some wholegrain carbs. Not processed sugary foods and pasta etc. Even with WW and SW when you reach goal they suggest you keep going to meetings to stay on track. I think with WW for instance it’s free once you get to goal but if you lose or gain more than four pounds you start paying again. You are supposed to keep eating the way you ate to lose weight.

We are not supposed to eat a diet high in processed foods and sugary foods and high carbs. We need protein, fibre, vegetables, some fruit and some whole grains.

For me personally I was dieting and getting bigger for 30 years. Ozempic has worked for me. I’ve still got more to lose but I’m getting there. For me I think it was insulin resistance. And if I have to take Ozempic for life along with changing now I eat it’s what I have to do.

But anyone who thinks they can take Ozempic for a few months and lose the weight and then just go back to eating the way they ate before is kidding themselves.

I think a problem with this though @Peridot1 is that we all have good intentions on diets and don't intend to return to our bad habits of eating processed food, sugary food etc. It is easy to be virtuous on Ozempic when you don't crave unhealthy food anyway - much harder when you are relying on just willpower. That same willpower that has let you down before.

Not many people will, I suspect, be able to maintain the healthy diet they find relatively easy while taking Ozempic. There is the option to stay on Ozempic for life or very long term but I'm not sure how many people are prepared to do that. I respect your position though, and that you are prepared to stick with it past the 2 year current guidelines.

Greensleevevssnotnose · 19/04/2023 16:01

Great post Twiglets. Absolutely any diet will be ruined if you go back to your old ways. That's how they get you hooked. I lost 6 stone on Cambridge for IVF and when that didn't work I comfort ate got divorced and ended up 10 stone heavier. Mine is absolutely blood sugar and insulin resistance, I lost 3 stone on hard core keto then came lockdown 1 stone on, then WFH another stone and then menopause another stone on. I've had enough, this works so far and I will keep on till it doesn't. It's pretty expensive longterm and I imagine they won't prescribe it once I reach a healthy BMI so will need another strategy then.

Peridot1 · 19/04/2023 16:06

I know what you mean @Twiglets1. I’m just trying to counter the whole “you will put the weight back on as soon as you come off it” brigade. You will put the weight back on as soon as you come off any diet. It’s not rocket science. If the way someone used to eat caused them to put weight on then there is something that needs to change. It may well be that weight loss from Ozempic is about as sustainable as with any other weight loss method but that is in people’s control to an extent.