Lupron

my friends daughter is taking Lupron she is 4 , years old , its been used in precocious puberty. I understand she has regular scans , she also takes various suppliments

it has been used sucessfully for PP for a number of years , without it girls would go through the Menopause , probably before they were old enough to even consider having children ,

its only been used to keep Puberty at bay for kids with GID a few years

as a number of girls with PP have gone on to have children , one would assume , its safer with trans kids ,insomuch as the shorter time they would be taking it the only aspect kids who take it may be slightly shorter than had they not taken it

to understand the legal ramifications , please read The Children's Act 2004
there is one legal argument if a child informs their parent they think they are Transsexual , and the parent refuses to act upon that, it is possible in theory that child might be taken off those parents, as has happened to adults who refuse transfusions on religious grounds

I am not for or against Luprons use , as treatment for anything , as long as its Dr/Clinictian lead

We discussed this at one of our womens only dinner partys, at the weekend , both lesbians /and straight women none of the women wanted other women telling them , what they should be thinking , or telling them what is best for their children

I have to live with the fact my father made me give my daughter up for adoption when I was 16

Lots of information here.
www.transgendertrend.com/puberty-blockers/

Lupron is not prescribed in the UK by the children’s Gender Identity Development service (GIDS) - they prescribe a similar drug called Triptorelin.

The UK endocrinologists at GIDS prescribe the GnRH analog called Triptorelin. Although slightly different to Lupron all these drugs are in the same class of GnRH analogs and all have the same mechanism of action. The mechanistic safety issues will most likely apply to the whole class of drugs.

Here is the full prescribing data:
www.accessdata.fda.gov/drugsatfda_docs/label/2012/020011s040lbl.pdf

Vaginal dryness is indeed noted as a side effect.

Here is a good thread where we talked about side effects. www.mumsnet.com/Talk/womens_rights/3288846-Article-on-the-side-effects-of-Lupron

This document is worth a look as it shows the manufacturer, ‘TAP has agreed to plead guilty to a conspiracy to violate the PrescriptionDrug Marketing Act and to pay a $290,000,000 criminal fine, the largest criminal fine ever in a health care fraud‘ (as of 2001)
www.justice.gov/archive/opa/pr/2001/October/513civ.htm

Are there good studies on what it does to young women? No. The drug is being used off label, there have been no clinical trials looking at safety in gender questioning behaviour.

The drugs are actively contraindicated in anyone with mental health issues (including anxiety and depression.)

Bowel are there studies on what that does to young women? Do they get all the symptoms of menopause, including possible vaginal atrophy?

Lupron is one of a class of drugs known as gonadotropin-releasing hormone analogues (GnRH analogues)

GnRH analogues interact with the GnRH receptor and modify the release of pituitary gonadotropins FSH (follicle stimulating hormone) and LH (lutenising hormone.) what that means is that when you inject someone with Lupron you shut down the production of testosterone in a male and oestrogen in a female as well. (Before that you have a stimulating effect and more hormones are released.)

They were developed in the 80s to treat advanced prostate cancer and then that was extended to cover endometriosis, uterine fibroids and eventually precocious puberty.

The link with bone density is predominantly oestrogen based - lower oestrogen and you lower bone density. Just as happens after menopause. In a female, what you’re doing is inducing in almost instant menopause.