Immune/NK cells pred thread #34

Fascinating how it all works! Also vice versa (but since I am 42 and he is 40, I think my egg quality could be worse than his sperm quality. Then again, I eat a better diet, so hard to say!).

Yep they listed hands, feet, arms, legs, stomach, bladder, etc including pallet.

@Objectiontime that is interesting they did look at the stomach and kidneys I think it was she listed them as she went through them. As soon as I see the heart beat I just kind of zone out lol xxx

@Gizmo1983 thank you. I'm just a bit edgy but I think everyone who has had our experiences would be the same. That is a very positive message and I will heed the words if the expert I think :).
Hope you are continuing to do well. I didnt mention but weirdly my 12 week scan listed all the body parts they could see. My friend said she only had that at her 20 week scan so that was interesting to me.

@TammyinCork Thank you and I'm sure I will. I am reminded that others have gone before me and weaned successfully at about the same time, ending with happy outcomes,

Regarding the sperm fragmentation I guess the first thing to say is that 3% over is more than you want but it could be worse so not disastrous. I recommend looking into some antioxidents for your husband in the first instance and I make sure he has some good quality Male fertility vitimins. I should also add that apparently sometimes if an egg is fertilised by a sperm with DNA damage the egg is able to repair it .

@Objectiontime this made me feel better

Medication is reduced gradually after 12-16 weeks. "By 10 weeks, the foetus starts producing its own steroids,’ says Dr Shehata. ‘I advocate weaning off the treatment from around 12 weeks, then the baby and the placenta produce natural components of these immune substances themselves."

Totally understandable to be wary... Really hope you get your answers when your bloods come back from the doctor.

My husband's sperm DNA fragmentation result came back and it is 18%, which is 3% over the healthy range. Did anyone else have something similar, and was Impryl enough to get it back to normal?

We are still waiting for my own results.

Aah bless you and thank you for your encouragement. You are right of course. 🥰🥰.

@Objectiontime I don't know what to say to reassure you because I don't know enough scientifically... But just think of all the women that have gone through this treatment and weaned off the steroids and its absolutely fine. They would not tell us to wean off them at this time if there was a worry. Plus I don't think NK Cells attack the placenta. I don't know if that's very reassuring, I just so want you to enjoy your pregnancy 💖🥰

Hi all, just getting more and more worried about the steroid weaning. Just thinking, if I wean off the steroids will the high NK cells and cytokine activity be likely to reactivate and attack the placenta?
I will obviously ask my doctor when I get my recent bloods back, just very wary! Xx

Ahh that's interesting, thank you xx

We are all with you. You will, get there xx

@Objectiontime with my first daughter she was quite small and my placenta was very calcified when she was born - Dr. S said it could have been that my immune system was beginning to attack placenta. Who knows what happened but it didn't have an adverse affect on my second baby (well obviously not second, but you know what I mean!)

This is great, thanks so much for sharing. Definitely going to be copying your 45 minutes of exercise and eating an egg a day too.

Thankfully my body now seems to be getting used to the Pred and my RHR has come down a few points. I was thinking this morning 'only five days to go' but of course, if it's worked then it'll be considerably more than that!

I hope everyone is doing well today.

@Lozzmax Congraulations on your little one. Hooe you dont mind me asking but I was just wondering why you were on hydroxy for your whole pregnancy? X

Thank you all for your congratulations, it means such a lot to have people on side.
Big congratulations to those who have had babies, wonderful news :)

@Objectiontime@Hopeandfaith1990 thank you both ❤️. Had my intralipid today and I will be 4 weeks tomorrow. Feeling really nervous and finding it hard to trust that any amount of meds will work. I will keep you all updated! Xxx

@Morgan236 Congratulations. Here's to a healthy and successful pregnancy for you x

Hi @Gizmo1983 They havent but I have now had tge bloods taken and I am going to start weaning from tomorrow. If they want me to raise the level again when my results come in I will but I am hoping they say not xxx

@Hopeandfaith1990 😂😂😂 your beautiful chart puts mine to shame I draw mine with a pencil and ruler I must get more technical 😂😂😂 seriously mine looks so similar we’ve even done the dates the same xx

@Hopeandfaith1990 Thank you for setting up the new thread, and hope all goes well with the oestrogen tablets. It sucks that we have to take so many medications - even the vitamins Dr S has put me on are a lot to take - but really hope they do the job!

@lozzmax and @kea1990, so pleased to hear your good news! An arduous process, but I've heard amazing reviews about Dr Edge from so many people, and how empathetic / reassuring she is.

@Objectiontime that must be an incredible relief! Great to hear...

@Gizmo1983 Really hope the migraines stop for you soon... That's great to hear that you reached the 15-week milestone.

@Morgan236 Congratulations, and wishing you well for the treatment ahead!

@Jecca88 Dreading moon face... May I ask what dosage you were on and from what point?

@Fletchasketch I listened to a podcast with Dr Thum where he said that he offers steroids from positive test. Others have taken them from 3 DPO.

@Newbeginnings22023 Wishing you well over this tough time, and taking a break sounds like a good idea.

I suspect I will be in the same boat as Objectiontime re: not being able to take intralipids, since I am allergic to peanuts and intolerant of soya! Will only start to TTC again once Dr Shehata gives it the green light / after getting results.

@Hopeandfaith1990 thanks for setting up the new thread.

To the new mums who have posted their success stories, I can't tell you how encouraging it is to hear- but mainly huge congratulations!

@Objectiontime so pleased to hear you had a positive scan, that's one very important milestone down, I hope the anxiety starts to ease a little from here.

@Gizmo1983 glad to hear your stitch is done, must be good to have it out of the way. I do hope the migraines start to ease soon.

@Newbeginnings22023 sending love and strength, what you're going through sounds incredibly tough. Taking some time out from TTC sounds like a good idea.

I'm just back from a week away visiting my partner's family- lovely to have some fresh air and home grown food! Now on day 4 of the post ovulation meds- I'm not really enjoying the racing heart I get from the Pred, does it settle down after a few days?! It's also the sheer volume of medications and supplements I'm taking now which is hard to keep up with. Not sure how I'll cope if it takes months and months. My losses were both around 8 weeks and so I can't help thinking medication from a positive test would be fine, will ask at my next appointment- sure it won't go down well though!

Hope everyone has a good week xx

@Hopeandfaith1990 Thank you for setting up the thread. So pleased to hear all is going in the right direction 💪* *

@Objectiontime Soooo happy to hear your news! I was wondering how you got on!

@TammyinCork It will feel good to have plan, I'm glad you had a good experience! I didn't have any problem with the medications, just the first time I took the steroids I blew up like a balloon. Weirdly after my ectopic, I didn't blow up - so it may be different for you.

@Newbeginnings22023 Sending so much love to you

It's lovely to hear so many positive stories! @Gizmo1983 You've got this! I actually found it very freeing coming off the medications but I completely understand your anxiety. Keep strong ♥

Much love to all xx