Immune/NK cells pred thread #34

@Jecca88 big congats on an amazing result- so pleased for you. Keeping my fingers crossed for the next stage. @Hopeandfaith1990 I had to google PUPO but it's a great mindset and I have everything crossed for you too. I remember the first time round I had cramps which I was sure was a period and then got a positive result. Good good luck!
@Deerdancer34 best of luck with the superovulation, curious to hear how it goes as I think that will be the next suggestion I get. Did you get anywhere with having the intralipids at home? I went for my second lot at CRP on Tuesday and it took over 2 hours out of my day- it's okay now as work is quiet but going to be trickier from September onwards so will be very tempted to do that at home. My tiny win is that my GP surgery has agreed to do my 'wellbeing bloods' so that's a few pounds saved.

Love and luck to all, I hope you're doing well.

@Jecca88 This is absolutely amazing news, gosh it makes me so emotional. We'll be waiting to hear 💖 Carry this high with you and enjoy that McD!

@Gizmo1983 How many weeks are you now? Will you look at gender at some point?!

@Hopeandfaith1990 Agh it's horrible waiting, its just the worst but anything you feel or don't feel doesn't mean a thing. Also I actually had really bad sleep when I turned out to be pregnant so it doesn't affect pregnancy if that's any help! Maybe try a podcast or audiobook when you're awake at night so your mind doesn't wander....And keep a positive mantra in your head when the negative thoughts start to creep in...I am PUPO, I am PUPO 💕

@SWMum9 Hopefully you get those referrals quickly?

My news is I'm gearing up to start Superovulation in September, we've decided to go straight to that. I do feel sick about having to do the whole process again and slightly anxious if have more losses, another ectopic etc but trying to close my mind to the what ifs. Plus I just have to think I'm in a better position this time because I do now have my daughter. I sometimes do get upset still that I can't just do it like so many women can do and that it'll never be an easy process or get that excitement at a pregnancy test that others get plus the time, cost and emotional worry...sometimes I feel like a child and want to stamp my foot and say Its Not Fair!! Anyway that's my moan 🤣

Lots of love to you all 💖

Wow @Jecca88 thats an amazing number absolutely amazing. Oh wow I could murder a McDonald’s ( gluten free 😢😢😢 ) we have the sex saved in an unopened file from the nipt at 11 weeks) take it easy today xxx
@Hopeandfaith1990 hey sweet absolutely any symptoms can mean everything and nothing I read up on so many people and how they felt some had none some had loads . Just keep yourself busy with nice things I’ve started sudoku it keeps my brain occupied when it’s running wild.
❤️

That’s amazing news 👏🏻!!

Hey ladies, had my first egg retrieval yesterday at kings fertility. Luckily we got 23 eggs which they constantly told me how surprised they were considering my AMH would have predicted only about 4 eggs. Anxiously waiting on the call to see how many fertilised, everything is out of my hands now. So relieved it’s over and had my post surgery McDonald’s fries and McFlurry lols!

@Hopeandfaith1990 congrats on being PUPO - what you doing to keep yourself distracted?

@Gizmo1983 that stitch sounds mental - glad you get it out at the end though. Are you going to find out the gender soon? Hope you’re ok my love ❤️

@Blossomvic hey my love, we have just gone through kings fertility which I think is the practice that works with CRP - but we very luckily got a referral that came through quite quickly. Think we requested our referral in April and just had my egg retrieval. It’s worth a shot asking GP if they came fast track you and then you can do the immune protocol alongside it with CRP and maybe even have an attempt over the next few months of just doing natural with CRP. Your partner can try and change the dna frag with diet and meds - and I think they retest in a few months to check if improved

@SWMum9 glad the GP is on your side and you get some clarity.

@TammyinCork @Deerdancer34 where are you at with your thinking? What’s next for you guys?

sending love to everyone xx

@Jecca88 @Hopeandfaith1990 @Deerdancer34 @CarpeDiem75 thanks ladies! They came back and advised that if my sneaked up to date (which it is) to get GP to make two referals. One to general gynae for the bleeding and one to fertility for the fact I’m not getting pregnant. She also advised to restart hydroxy as it doesn’t affect my cycle.

Ive got a GP apt this week so atleast I can be proactive. Was hoping they might say something more helpful lol

Omg @Hopeandfaith1990 thats awesome watch lots of funny/happy films laughing/warm fuzzy feelings in studies got higher implantation ☺️.
@Jecca88 yes the pain after the placement was something else dihydrocodeine and oromorph didn’t touch it for the 1st 12 hours but then some women get no pain at all ( typical I wasn’t one of them lol) no this one will be removed when/if I get to 36 weeks xxx.
@SWMum9 hope you’ve made some progress today xxx

@Hopeandfaith1990 Marvellous news, I've been wondering how it went! Keep us updated!!

Hi ladies, newbie here :)

I've just started at the CRP clinic after 3 early losses, low AMH, high sperm fragmentation, normal NK cells - we were advised to go ahead with IVF in the interest of time, wondered if anyone has done IVF at the clinic or if it's normal (& easy?) to go to a different clinic that will work with them on the immune side. Despite my NK results coming back as normal, I want to try everything I can on that side too 🙏

Any advice gratefully received! Wondering where to start with IVF clinics.. or if I even need to do the immunology stuff if my results are normal! 🫠

@sw9 hoping they come back with something today, but otherwise i would ask for a scan and some bloods. If the hosp say no - try the GP?

Thanks @TammyinCork :) what are your next steps?

@Gizmo1983 glad the stitch went well, but can imagine lots of recovery. did they discover you needed a stich with your last loss? or was it just something that came up this time? Are you in lots of pain? Does this mean you will need a C-section?

Hello my lovely lovely ladies. Have just caught up with everything and the stages where everyone is at.
i think we are all such fighters and crikey sometimes it just is sooooooo bloody hard isn’t it.
im getting used to stitch it’s been a pretty long recovery and I think my way of coping is just going into myself and I need to pull myself out of this.
@Hopeandfaith1990 so sorry you hit a low I’m pretty sure the same happen to me I think you’ve just been through so much to get to this one point and it’s a lot to deal with mentally.
@jecca that’s sounds like you are going to get some good numbers
@SWMum9 i absolutely feel for you after my 2nd loss I just could not get pregnant again. It sounds like you definitely have something going on could it maybe be a polyp or fibroid I had similar and it was a polyp. You defo need investigating don’t let the nhs brush you off xxx

No I haven’t been scanned since the beginning of the year and my last blood tests were February also.

hoping the doctors come back with something on Monday rather than just ‘keep trying’ which is super unhelpful.

we are thinking about going to Greece next month for some investigation too. That will be a saline scan, endometrial scratch and microbiota test. I think we will just go for it and that may give us some answers and if it’s all fine then that’s good too!

@Jecca88 Sending very best wishes for the egg collection - hope all goes well!

@CarpeDiem75 and @SWMum9: So sorry to hear you're going through this. Some ladies in the UK Recurrent Miscarriage Support Group on Facebook say that taking progesterone from ovulation day has messed with their cycles... Probably why there is a difference of opinion amongst doctors re: taking it (and prednisolone) from ovulation, 3DPO or from positive test.

@Hopeandfaith1990: Sending you my warm thoughts. It's such a lonely (often protracted) journey and I'm so glad to have the support of this group of women, plus the Facebook forums.

Thanks @Deerdancer34 really hoping we can get something from this!

@Hopeandfaith1990 - keeping everything crossed for the next two weeks for you - I really want this to work for you.
so I only originally booked off the EC day but gonna book off the two days after I think. So nervous about that 5 day wait.

@SWMum9 hoping the midwives come back with something Monday. Have you been scanned at all in the last few months? Or any blood tests?

Ah that’s helpful to know. No, not on Letrozole. I really felt hopeful for the protocol but I feel it’s only set us back as now I don’t know my cycle or body at all where as previously it was like clockwork with EWCM and then positive OPK. I don’t get either now.

@SWMum9sorry about your issues. I am under Dr S under the nhs too and under the same protocol as you but I do super ovulation privately. I have not had issues in my ovulation however I did notice that I have no symptoms after ovulation which is really weird for me as I always have breast tenderness or sensitivity after ovulation (Even if I am not pregnant!) which makes me worried that my hormones are not as strong as they should be during the luteal phase… I have a 6month follow up appointment in September and I will definitely ask them about it.

are you on letrozole? I know this can cause some spotting (I had this before but very very light)

@Deerdancer34 @Jecca88 thanks both. I’ve emailed my concerns in for the last two months and was just told to keep trying.. this month I said look I’m having heavy spotting again when I should be ovulating and I know something is wrong. The midwife said she will discuss with the doctors Monday and let me know. Fingers crossed. Would rather stay nhs care if I can for financial reasons but equally I don’t want the age gap between my first and second becoming even bigger but hey it is what it is x

@Deerdancer34 @Jecca88 thanks both. I’ve emailed my concerns in for the last two months and was just told to keep trying.. this month I said look I’m having heavy spotting again when I should be ovulating and I know something is wrong. The midwife said she will discuss with the doctors Monday and let me know. Fingers crossed. Would rather stay nhs care if I can for financial reasons but equally I don’t want the age gap between my first and second becoming even bigger but hey it is what it is x

@Hopeandfaith1990i am really sorry you are feeling like this. I know it is hard to feel positive about the whole process as we always have that fear of miscarrying but I will cross everything for you! Who knows ivf is a new process to your body so that a new beginning!😊
i am feeling really down as i am not even able to fall pregnant now I have all these medications. It took us 4 years to finally get the formula right to get pregnant ie letrozole plus Preseed and now I have all the immune treatments it doesn’t even work anymore.. I am feeling so defeated. I also keep getting false positive as my body is ultra slow at absorbing the trigger shot (still there at 14dpo)… so it is hard mentally…but I will carry on!

has anybody else had issues to get pregnant once on an immune protocol (pred and hydroxy)?

@Hopeandfaith1990 Well done for getting out, I actually think that really helps too but it's very hard to make yourself in the first place! Gah don't feel guilty! Sounds rather a nice salad though 😄 Focus on a nice weekend 😉

@Jecca88 Sounding really good 😎

@SWMum9 See what they say before you switch! They really should be giving you answers...

Oh @Hopeandfaith1990 my love, im so sorry you're feeling this - i have had so many of those and when ever i get a positive pregnancy test i feel that doom and it does change. Each day at a time and you're doing everything you can to try and make this a success, these are good embryos and you're on the immune protocol - this is a completely different process for you with the IVF.
Had another Scan yesterday and i now have 26 follicles, 22 of them are a good size, but won't be triggering until Monday, so egg collection on weds. I feel like a whale and will take your advice and only wear floaty dresses from now on.

@SWMum9 sorry to hear you're having side effects from all the meds and that it has been a while for anything to happen. The only thing thats different from the CRP private is the intralipids and i think you could get them elsewhere? I know that if you do get pregnant the scans are also £300 each and consultations and thats every 2 weeks. Unless he thinks you need more than intralipids, then there are loads of other meds, but he wouldn't let me mix NHS and private and i had already gone down the private crp route before my referral came through for the NHS st helier. Plus you also have to pay for the meds and don't get them on nhs prescription. Just something to think about - i have spent £15K with CRP already.