Immune/NK cells pred thread #34

Please don't worry, you haven't. I've been asked to stop aspirin because of a small bleed near to my cervix, apparently the aspirin might make it worse. I trust Dr Edge implicitly, I think I was just surprised as I know it's so commonly used in cases of recurrent loss. Really appreciate all the info from you and the rest of the group, you are all so amazingly knwoledgable.

Hi all, I know this is a PA odd thing to ask on here but my consultant wants me to deliver at 37 weeks if I get there via induction or c-section He thinks this is sensible to try and avoid the placenta starting to reduce in efficiency. Not too sure what I think about this. Interested to know if this is the usual view if anyone knows xx

@Deerdancer34 Really interesting about you being asked to come off the aspirin too. Did they tell you why?

For me, all fine so far, nearing 23 weeks xx

@Hopeandfaith1990 Just wanted to wish you well for tte hysteroscooy tomorrow. Heard only positive things about this procedure's helpfulness on tge journey we are in xxx

@Fletchasketch I wanted to come back to you on this because I didnt want to cause you any confusion or issues. When my specialist said he wanted to check placenta and blood flow he didnt specifically say why to be honest. I assume it was to do with any cytotoxic activity remaining that could cause issues for tge blood flow and placenta, maybe by clogging it or other but, as I say, he didnt specify and I didnt ask. I do know that tge aspirin is to help blood flow and I have been on 75mg per day constantly from even before I was on the pred initially last year. My specialist wanted me to remain on the aspirin right tge way through the pregnancy, although I have no known clotting issues or similar. I was advised to move up to 150
Mg from 12 weeks, which is pretty common but I have never done so because I have celiac disease and aspirin is not ideal medication for those of us with this disease, even the gastric resistant ones as it is a bit heavy on the tummy.
Guess what I am saying is that you may want to ask why they want you off the aspirin.
Xxx

Thank you 😘. Hope all goes well with the hysteroscopy tomorrow, I will be thinking of you. One more step in the right direction.

@Fletchasketch Huge congratulations, every milestone is a step forward in the right direction isn't it!? I'm so thrilled 💓 I was also told to come off the aspirin early.

@Jecca88 I think I woke early every night through most of the first Trimester and I used to panic about getting to sleep. The only thing that worked for me was putting on a podcast so I could concentrate on that rather than trying to sleep - I would either drift off or be in a near sleep like state so at least you might feel more rested. Just thought I'd mention in case any help!

@Objectiontime Hope you are well!

@Hopeandfaith1990 Good luck tomorrow!

@Objectiontime thank you, this is helpful intel. I think my main concern about giving up the aspirin was the blood flow element, I hadn't realised that was what the Pred was for, so good to know. After being initially resentful of these endless appointments that seem to cost a million pounds a go, I'm now really grateful that they are keeping such a close eye on me. Wishing and hoping are the order of the day. I'm sorry to hear it's still a bit worrying for you, honestly I don't think it will go away for me until I'm leaving the hospital with a baby. Wishing you all the best x.

@Fletchasketch it is really hard to let go of the worry isn’t it. I I started tapering the Pred at 13 weeks and was at 5mg by 17 but then I was told to stay at that level until an ultrasound could confirm that the placenta and cord blood flow looked normal. This was because a recheck of my immune cytology at 12 weeks had shown there there were still a few niggles. I came off the Pred after the blood flow and placenta had been confirmed as at least looking normal but I am forever fearing a relapse of dodgy immune system damaging the placenta. The fear doesn’t go away but I think all we can do is try to enjoy it and pray. xxx

Thanks, everyone. Small wins indeed! It certainly did feel like a milestone. Up until now my partner and I have completely avoided talking about the pregnancy, beyond what we absolutely have to in terms of appointments. I'm so cautious to acknowledge that it might be happening but we were able to talk about it last night, which felt good.

@Jecca88 yes, the next hurdle is the NIPT test which will be in two weeks, we're defintely going to go for it, terrifying prospect as it is. Re: the aspirin, Dr Edge noticed a small bleed near my cervix, so said it's best to avoid it.

Sorry to hear you've been feeling shattered, I do think it's normal though. I felt rubbish and had disturbed sleep on the Pred for about the first 5 days and then I think my body started to get used to it and now it doesn't bother me. How long have you been taking it for now? I also read somewhere that taking it super early in the morning helps with sleep- though that does mean having a very early breakfast which I wouldn't be keen on. I really hope things ease up for you soon and that the pregnancy continues to go well.

Sending lots of love and luck to all xx

Brilliant news Fletchasketch, really chuffed for you xx

Also @Fletchasketch did she say why you need to stop aspirin? Your blood work? Have you had any bleeding?

Amazing news @Fletchasketch small wins and each day and this is the furthest you have ever been! Remember that. They do say if you get to 10 weeks you’re in the safe zone for immune stuff! Have they started talking to you about the harmony testing yet?

I have been sleeping terribly since I started the protocol on Sunday. Last night after the GCSF injection I woke up at 3am and couldn’t get back to sleep. Such achey legs and lower back. I feel shattered today. CRP have recommended I come down to 20mg of pred like before- hopefully that will help me sleep better. Any tips welcome?

@Fletchasketch ahhh that is incredible news!! I’m so happy for you. Hope you can relax a bit, for today at least! Xx

There are just so so many things to consider, it's an absolute minefield and SO SO expensive!

My scan was this morning, was unbelievably nervous, barely slept last night but thankfully saw a strong heartbeat and now measuring a bit ahead at 8w5. Not out of the woods yet, but it's the furthest we've got so for now I'm happy. Dr Edge has told me to stop the Aspirin which makes me nervous, but she's given me good news twice now so I'll pretty much do anything she says at this point.

Hope everyone else is doing well x

@Fletchasketch thanks so much! It’s interesting isn’t it, I feel if things don’t work out this time I’ll be wondering if this is a factor…it’s a (very expensive) process of elimination going down one route at a time, but I just try and remember we’re doing the best we can with what we know at the time! Anyway, for now probiotics have been ordered. It’s so hard isn’t it - this is also a critical time for me, trying to distract myself as much as possible by watching lots of trash on tv. My 6 week scan is next Wednesday. When’s your next one?

@Jecca88 great you’ve got everything in place so quick - the timings sound good, hope your first injection went ok tonight? I haven’t done g-csf so nothing to add I’m afraid, but I always have a bit of a wobble when I first do injections. Then I get used to it, and feel quite a sense of achievement that I’ve done it! I’m with you on the early weeks - I just want to know so I can deal with it either way. I emailed CRP today to double check on probiotics and they said it was fine.

x

Hey all, thank you so much for your well wishes and congrats.It means so much. Had my Intralipids this morning and got all my meds topped up. Injections arrived this afternoon so starting them tonight. Has anyone taken the G-CSF before?

I also did a Clear blue and it says 2-3 weeks, so probably only 4 1/2 weeks i reckon. I have my first scan booked in next Friday. I hate early pregnancy - one min i am like maybe this is the one, next i am like its doomed, hoping the miscarriage will happen sooner rather than later.

@MC8 i am going to email the nurses as wanted to ask about Magnesium, i will also ask about Probiotics too. I have had accupunture before - but never when pregnant, but i have a voucher from my birthday that i want to use so think i might go that after the 6 week scan if we make it that far.

x

Amazing news, @Jecca88! Wishing you very well for this new pregnancy!

@MC8 glad to hear you had a great acupuncture session, I always come away feeling so relaxed and also cared for, it's worth every penny. I was taking probiotics whilst trying to conceive, I used to get thrush ocasionally but haven't since and so they were worth it just for that. These are the ones recommended by my acupuncturist that I used https://www.ebay.co.uk/itm/406222440536?chn=ps&_ul=GB&_trkparms=ispr%3D1&amdata=enc%3A128Ghvf2DRRiocuWXCtvXCA24&norover=1&mkevt=1&mkrid=710-134428-41853-0&mkcid=2&mkscid=101&itemid=406222440536&targetid=2361954446071&device=c&mktype=pla&googleloc=9045979&poi=&campaignid=21701214154&mkgroupid=168798367673&rlsatarget=pla-2361954446071&abcId=10027104&merchantid=5614842426&gad_source=1&gad_campaignid=21701214154&gbraid=0AAAAAD_Lr1cWe2Z_A5MxU_iUOYbF3VcGB&gclid=Cj0KCQjw9JLHBhC-ARIsAK4PhcrUe2_Fam7Bra1g3BGVibSXV-mhLWmPF-79M3WrOJRHKM3oqX_gx2AaAg08EALw_wcB

I'm also curious about the microbiome, and Shehata discusses this on the podcast episode he did with Hannah Pearn. He basically said he's open to it being a factor but that there it's still an evolving field and there's not a huge amount of evidence out there yet. Link to the podcast in case you're interested: https://hannahpearn.com/2025/06/06/101-miscarriage-and-your-immune-system-with-dr-shehata/

Hope you're doing well and surviving the stress of these early weeks. I am approaching the time that my previous losses were so the stress levels are high.

@Jecca88 all the best for the intralipids today. I'm sure you'll feel reassured just being there and knowing that they've been done.

@Jecca88 brilliant you can get the intralipids tomorrow! They were so lovely at CRP when I went last week, so I hope they put you at ease.

@Hopeandfaith1990 best of luck for Friday!

I went for my first acupuncture session in over a year this afternoon and was reminded how relaxing it is - so thank you to everyone who suggested it :) I caught my acupuncturist up on everything since I last saw her and she hadn't heard of CRP/Dr S but was very supportive of the protocol and agreed that it feels aligned with my general history and health which was reassuring.

She mentioned I should be taking probiotics. I think i saw some discussion on probiotics here, is anyone taking them? I can't remember if they're ok to take with the meds (pred, hydroxy, progesterone)? She said to look into Zita West but I'd love any recommendations if anyone is taking them.

She also asked if I've had a uterine biome test done. It's too late for me to do it now, but was wondering if anyone has done it or spoken to Dr S about it?

Gentle congratulations @Jecca88. Keeping everything crossed for you.

OMG @Jecca88 Amazing news! Gentle congratulations to you. Dont stress about the meds, start as soon as you can and wishing you the absolute best for this one hun xxx

Thanks everyone, really appreciate all your support and so glad to have this group. I have called the CRP and they said not to worry - they have booked me in tomorrow for intralipids and put the prescription through for GCSF - which i should hopefully get tomorrow.

@Hopeandfaith1990 it is a total headfu*ck, you should have seen me staring at the preg test, like a cartoon character rubbing my eyes as i couldn't believe what i was seeing. It didn't help that i had been at a birthday the night before in central london and got home at 2.30am, also had a few drinks :(. I have ordered the clear blue - should be arriving today so hope can shed a bit of light. Thanks for the tip hun. When is your Hysteroscopy hun?