Immune/NK cells pred thread #34

Any tips for first scan nerves? The last time I was at EPAU was for my first loss. I’ve had 3 more since but never made it to a scan.

That’s interesting about the pred… I do feel worse in the evenings and my boobs are like rocks! I have had back cramps a lot which I had early on with my son so just trying to tell myself it’s a good thing

Congratulations! I have my scan tomorrow at 7 weeks 5 days. Symptoms have been on and off but really only started up this week. Feel quite queasy if I'm hungry at all so have been eating a constant stream of toast! feel a bit emotional and anxious too. I have had a couple of dreams that there is no heartbeat at the scan :(

@Hopeandfaith1990 sorry to hear about the bleeding, that must have been really hard - especially at christmas. I am still looking for blood each time I wipe

Hey gals - hope the first day back at work isn’t too awful for those of you who are back.

I have my first scan tomorrow at CRP. Will be 6 weeks 6 days and I just don’t feel positive at all. I have essentially zero symptoms despite having a few last week and some crampy left sided pain has completely gone. I am on a load of medication (prednisolone, progesterone amongst others) and know they can mask so I hope it’s that.

Anyway, I’ll let you know how it goes. Just telling myself whatever happens we’ll get through it because we have to. @SWMum9 good luck with your scan too.

@TammyinCork im sorry for the disappointment in your results. It’s all so f*cking bollocks

Glad all is looking well so far! Yes, we did do ICSI and SpermSlow but the doctor was hinting that we might not even have needed it... It seems to be more my egg quality that is the problem sigh All these years of healthy living and they haven't translated into blastocyst formation...

Happy New year ladies, hope everyone is looking forward to this new year and what it holds for us all. I am glad to see the back of 2025, which may have been my hardest year yet. Ended up having a huge row with my sister on NYE - never have a felt pregnancy rage like it. I can;t even blame it on the steroids nows.

@TammyinCork my love i am so sorry to hear about the drop off, how incredibly hard when you responded so well and had such good result from EC. I am holding out hope for this 1 embryo. It only takes one they say. Did you do Icsi?

@Hopeandfaith1990 how are you getting on? Have you got anymore scans booked in?

Just a update on me, just had my intralipids, had a scan on monday, and now 17 1/2 weeks. All looking good, still cannot believe it. Told a few people - friends and family - which has been hard really - managing everyones responses and their excitment when really I am still so tentative. Wish i could have kept it a secret really.

Much appreciated, Gems, Pagey and Hope and Faith. They will get back to me in 2 weeks with PGTA result. If normal or a high-level mosaic, they will transfer, but anything less than that and I'm back to the drawing board, and can either do another cycle or stop with them. I've organised a phone call with ARGC London to see what they offer... While the Spanish clinic have been very good, I think I need a more tailored approach / daily monitoring, and maybe even human growth hormone (which is not offered in Spain). I have heard it helps with blastocyst and euploid rates, and might make sense for me, given that in my six naturally conceived miscarriages, they were always measuring behind.

Thinking of you @TammyinCork❤️❤️

I'm sorry to hear that @TammyinCork , the days following collection are just excruiating, do you have much of a wait for the PGTA results? I've got everything crossed for you. If you get a segmental, a chaotic or a mosaic rather than a full euploid they still have a chance. Do you know if your clinic offer genetic counselling to tell you more about your results when they come through?

Thank you all for your support... Unfortunately, we got bad news this morning: only one of the 7 fertilised eggs made it to blastocyst, and it has now been sent off for PGT-A testing. Beyond disappointed, especially as the initial results seemed so promising. Apparently, most of them fragmented by Day 3.

@TammyinCork I am very well, thank you. Hope everything goes well for you. Everything crossed for you xx

Those results are great @TammyinCork ! To have 9 collected in the first place, and your attrition is good, you haven’t lost many at all. I was on Pergoveris as well, it’s supposed to be good for quality for women our age. I’m 41 and the most I’ve had is 8 eggs collected. Best of luck with your blasts and PGTA results, have you joined many fb groups? There are a few for PGTA, I joined because I had a curve ball mosaic embryo and wanted to learn more about it. I was expecting only euploid or aneuploid, Hope the soreness passes soon and you get more good news in the coming days xxx

@SWMum9: Many congratulations... Such lovely news for you and your OH before Christmas!

@pagey23 A very useful affirmation - thank you for sharing! Wishing you all the best for the superovulation.

@Hopeandfaith1990: Tommy's were always against NK cells treatment, from what I remember - they don't believe it's a thing. It's the reason their clinics rarely prescribe steroids, unless a lone doctor goes against the "script" / turns a blind eye. Sorry the call with the EPAU was so draining... They don't seem to realise that asking for people's histories over and over again is so exhausting for them!

@Jecca88: Congratulations on reaching 16 weeks - an incredible milestone :-D

@Objectiontime: Great news that you have reached 33 weeks! Hope all is going well with you.

@LoudAquaMoose: That's amazing re: the ovarian PRP and good to know that CRP offer this!

Sending good wishes to everyone, and hoping 2026 is good to us!

In terms of my updates, I was able to go ahead with our first cycle of IVF in Alicante. I was on Pergoveris and had my egg collection on Christmas Eve (ouch - I was sore for several days afterwards and am still not 100%). 9 eggs collected, 8 mature, 7 fertilised. Now waiting to see how many make it to blast in two days' time... We will then have PGTA testing.

Are these OK results for 42 years old (husband is 40). We had ICSI and the Spanish equivalent of Zymot, called SpermSlow.

It’s soooo great hearing these positive stories and gives me so much hope!! Congrats to everyone - it must be so lovely to be pregnant this time of year.

my journey continues to plod on BUT I’m on my first round of SOP and it went really well. Omg what a relief it is knowing exactly when you are going to ovulate - it’s soooo less stressful! I found triggering myself quite hard. It took us about 15 mins and at one point involved me lying on the kitchen floor (!). In the end I just couldn’t do it so my husband found some courage to get it done for me. I should have ovulated yesterday but today I had lots of EWCM which confused me so we just did it again today for good measure. I need to take a pregnancy test on New Year’s Day. I’m definately going to keep up with the SOP - it’s so much better and wish I had been able to do it earlier.

My husband and I also bought a baby blanket and wrapped it up to put under the tree - it’s an old wives tale but is meant to bring you luck. Anyone else done that?! I thought it was quite a sweet idea…. Husband bought a blue blanket though 🤣🤣

have a great Christmas everyone! Lots of
love and thank you for the support. Here’s to a great 2026 for each and every one of us. We bloody deserve it!!!!!

Hi all,
@Hopeandfaith1990 I do know what you mean. It is encouraging to know that we can have success despite our immune issues and I always found reading others'positive stories made feel more hopeful. No hydroxy, just the prednisone on the immune side. I did have progesterone to 14 weeks but only as a precaution, not for any known concerns with my levels. I am also on low dose aspirin and have been since before conception.

@Jecca88 I am well but very tired :) Not that I am complaining of course. Yes, it is a bit luck of the draw when dealing with the NHS. I am having a little girl. Was obviously happy either way :). Brilliant that you are now 16 weeks.

@Hopeandfaith1990 thanks for your reassuring words. It is very common i think and went to my Obstetrics appointment today and they did a doppler scan and his heart is still going very strong. So relieved and actually think i just prefer that to a scan. I am 16 weeks today and back at CRP next week for another Scan and Intralipids. I stopped the aspirin whilst i have the brownish discharge. I think i might continue on the progesterone till 20 weeks, will see what Dr Edge says.

@Objectiontime so nice to hear from you and wow 33 weeks, how are you feeling? has the anxiety got any better? Thats great you have a good consultant at the local hospital that isn't totally against the Immune stuff. I always find it so hard to navigate with the NHS when i list all my meds lols. Do you know what you're having?

@SWMum9 if you can wait - do it till the 7 week one. I actually registered with NHS after my 12 week nucal scan with the CRP. I just couldn't face all the appointments if we were going to lose it again. They fit me in s quickly for my NHS scan and midwife appointment and understood why i waited.

Merry Xmas everyone xx

@SWMum9 I actually waited until 9 weeks this time, just couldn't face it before that. I had had 3 scans by that time and thought i should probably get on the midwife list x