Immune/NK cells pred thread #34

@Hopeandfaith1990 I don't know if it helps but they start reducing from 12 weeks as the placenta is taking over looking after your baby 🥰 It is scary but then I eventually loved not being on drugs all day, every day🤭 (I weaned from 12 weeks (which I think takes you up to 16 weeks ish and came off Cyclogest at 16 weeks)

Hi ladies, I just wanted to apologise if my joining in conversations is a bit lacking. Sometimes my post button seems a bit iffy !!

Hi @Hopeandfaith1990 of course I dont mind you asking about my weaning process. I was on 25 dose of pred till 13 weeks and my consultant, when I asked him, said I could wean off from 13 weeks by 5 per week. This would have had me off pred by 17 weeks. However, the other choice he gave me was to get my immune s rechecked at 13 weeks and see how they were and then wean off if all was looking okay. I opted to do both so I started weaning at 13 weeks and had another blood test (over stg1000 paid again). The results took about two weeks to come through, if i remember rightly. The blood test showed that my levels of NK cells etc had dropped but they were not perfect. This did worry me a bit to be honest. I continued, however, weaning but he suggested staying on the 5 dose until I had positive news re apparent health of placenta and related blood flows at my 20 week scan. This was the case so I came off pred completely then. I was on progesterone (cyclogest) until I was 14 weeks. Xx

Thanks for the message guys! Funny how mumsnet is the place to go for reassurance as no one else will ever understand! I actually found another thread from 2016 where the same conversations and worrries were being discussed by another group of women who all seemed to go one and have their babies. So hope this is the same for us all - no reason why not!

I have my 8 week scan on Tuesday - should be 8+2. The furthest we have got whilst still having a heartbeat is 8 + 1 so this is an important milestone! @Jecca88 did you restart the aspirin after the spotting stopped?

Best of luck @Gems2811 with your transfer. Have everything crossed for you and have the faith that this will be your time.

enjoy the weekend!

Ahhh @Gizmo1983 that had made my year, so happy to hear about your baby girl Elizabeth. I really hope you're enjoying your newborn bubble, i bet you can't believe you are here after everything you have been through.

@Hopeandfaith1990 fantastic news my love - will you start telling people now? Would the PGTA have picked the three major ones or is it still a risk?

@LoudAquaMoose oh my love - i had brown spotting too and the fear is soo real and you're bound to think the worse considering what you have been through. Just know that after the spotting you saw a heartbeat so its not related to the baby and it can happen again and the baby can be fine again. Stopping the aspirin also stopped my spotting which is a relief.

@RosieLouiseWilliams hello my love, its Jessie the one from Insta :) good to have you on here and been following your journey. I am keeping everything crossed for you this cycle. I never had the itchy, but the Pred made me a bit crazy - i am glad to be off it - wow my face has gone down in its puffiness and also my appetite has really gone down - i get so bloody full.

@Gems2811 good luck next week with your transfer. Will be keeping everything crossed for you too.

I am 19.3 weeks atm, got a midwife appointment today and every appointment am still so afraid.

Thank you @LoudAquaMoose , gosh I truly emphathise with the anxiety, it's just absolutely exhausting torture. Hopefully it was just the aspirin causing the spotting and your 7 week scan is positive news too. Every minute feels like eternity, but the days do click over into weeks. All that helps me is thinking of it as keeping putting one foot in front of the other.

And thank you @Hopeandfaith1990, this is so great to have had a positive 12 week scan and come back low risk for the trisomies. I'm so relieved for you!

Beautiful to hear from you @Gizmo1983 and your absolutely wonderful news

Also congrats @SWMum9 ! The hair stuff does go back to normal eventually...

How are you doing @Jecca88 and @Objectiontime ? Fingers crossed for your cycle @pagey23

Welcome @RosieLouiseWilliams , everyone here is so lovely, and there are so many pregnancies, it really gives some hope

I'm off to Athens on Sunday for my embryo transfer, we're transferring an embryo which we collected at the beginning of last year, before my endo surgery and before our loss, and so I'm equal parts absolutely petrified and hopeful that all this was just a bad dream in between. I'm having acupuncture and a fertility meditation before I go into the clinic to try and get into a headspace of new energy!

@Deerdancer34 Thank you so much for your kind words. Yes it is a shame however I am so grateful for forums like this where we can chat about it. Thank you for giving me hope regarding the superovulation treatment that is really helpful. Exactly I am holding on to hope and positivity that we will get there and one day I will be able to meet our baby soon.

@Hopeandfaith1990 Thank you for giving me all that information regarding the hydroxy. It does make me feel reassured. I was off pred for 2 months roughly so I am not looking forward to looking bloated however I am telling myself that when I am pregnant I will be bloated so this is prolonged pregnancy before pregnancy (haha).

That must feel amazing being that far along but yet so scary too. I really hope you find the next few months steady and your able to enjoy it. Was there a reason you didn't do the superovulation cyle at all? Sorry to ask such questions, it just helps me better understand your situation and help me work out what we do. I have a frozen embryo on ice still but it is our last one and we were thinking of doing a full round of IVF however Dr S felt as I ovulated normally, apart from having a low AMH (6.6) he felt that we should do the SO protocol first. I have had a few chemical pregnancies and never made it past that stage even with IVF we had 2 and that is why we are now with the CRP clinic as I felt there was something going on. sorry for the LONG message. xxx

@RosieLouiseWilliams Hello Rosie, welcome! Sorry you're here. If it helps I eventually conceived my first daughter on Superovulation protocol. Aside from the medications, I take Pregnacare Plus, Vitamin D, COQ10 100mg, baby aspirin, Inofolic.

I'm currently on my 5th round of Superovulation and the Prednisolone is making me feel crazy...makes me think its not worked but I know deep down you can't really tell until you do the test. The joys we put ourselves through but you don't care if there's a chance of holding that baby!

@Hopeandfaith1990 Thank you so much for getting back to me so quickly and thank you for your kind words it means a lot.

I have been on hydroxy for probably 1 month now. I have found my skin is very dry on that but not itchy. Itchiness started last night and I was on day 2 of taking omeprazole, pred and progesterone. I have taken pred before but not in the high dosage. It has settled a little today but was itchy this morning.

I have read so much about them and I am thinking maybe I need to do more research into the ones I take and if they absorb the same as Naitre. Thank you for being so open about it. How far along are you? Did you get pregnant via the superovulation protocol ?

xxx

Hello all,

I am new to this and have just started with the CRP clinic. I am currently in my first superovulation cylce and I am day 2 into taking the pred, omeprazole and progesterone. Did anyone have itchy skin from any of the medication?
Also I would really like to know what prenatal vitamins everyone has been taking? I am taking Proceive Max Sachets but wanted to see what everyones opinions are?

Also congratulations on all of the pregnancies, it gives me so much hope. I really hope this works for us 🙏

Thanks @Hopeandfaith1990 and @Deerdancer34 I’ll try both of these! Hadn’t considered sending pictures to chat gbt haha!

I think the ‘you can’t change it and you’ll deal with it if it happens approach’ is a good approach. Thank you!

@Hopeandfaith1990 congraz darling!!! Sooo good to hear ur wonderful news!! Enjoy it!!!! U deserve it!!!❤️

@Hopeandfaith1990 Amazing news hun, really happy for you xx

@LoudAquaMoose Bless you, its so hard. My mantra was 'I am pregnant now, if something happens I'll deal with it then because I'll have to & will have no choice.' It sounds silly but its the only thing that got me through the early weeks. It was to try and stop my mind careering off down a black hole. Keep going, every day is a step forward 💪

Congrats @Hopeandfaith1990 thats such great news!

I had a dramatic weekend with some spotting on Friday and the weak symptoms I had completely going. I went into full meltdown crying the entire weekend. Scan at EPU on Monday showed a heartbeat and 7 weeks 2 days which is about right. After stopping aspirin I have had no more spotting.

I have actually been signed off work for 2 weeks because I am in such a bad place pregnant again. Grateful ofc but always expecting the worst. It is an absolute head fcuk.

Any words of wisdom from those out the other side. Were you the same?!

@Hopeandfaith1990 Wonderful news!! I know there will still be fear but I hope you can enjoy your pregnancy now, it's so wonderfully special 🥰💞

🥹🥹🥹 lovely stuff!! Huge congratulations ❤️❤️❤️❤️

@SWMum9 Yes, it does seem to have different effects on different people. I started on 25 g pred and then tapered from 13 weeks until I got to 5 g per day but i had tge blood tests again at 13 weeks and although they were down my immune levels were still a tiny bit iffy so i had to stay on the 5g until the scan at 20 weeks showed the placenta was looking okay and the blood flows were fine. That said, i could not have the intralipids because of allergies so it was pred, cyclogest and aspirin for me. Xx