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Conception

When's the best time to get pregnant? Use our interactive ovulation calculator to work out when you're most fertile and most likely to conceive.

TTC Active Letrozole Thread

497 replies

Angelselevenx · 28/02/2024 17:09

Struggling to find an active Letrozole thread. Recently been prescribed Letrozole as I have low progesterone and signs of ovulation not being as effective as it could be, albeit I still ovulate on my own.

Would love to hear success stories or chat to people who are going through TTC with letrozole now x

OP posts:
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Angelselevenx · 12/03/2024 18:43

CD9 today and been getting a fair bit of ovulation pain, not expecting O to be yet as I don't normally O until CD20 but something must be going on in there 😆

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Loz365 · 11/03/2024 15:49

@Dija89 oh my gosh!! Yay!!! I knew it! 😂 congratulations!

@Daydreaming91 good luck on Friday! Yea the hot sweats were my worst side effect, it really affected my sleep. But it worked so at least it was worth it in the end 😆

Daydreaming91 · 11/03/2024 14:33

@Dija89 thanks for sharing, this is my first 'official' cycle of letrozole. Waiting for my follicle scan this week so keeping everything crossed for the next few cycles. I hope the breast pain eases.

@Optimistic66 hi, I'm just taking letrozole at the moment, no trigger shot. It's nice to actually feel like you are in a level playing field with ovulation, fingers crossed for you

Optimistic66 · 11/03/2024 13:46

Dija89 · 11/03/2024 09:37

@Loz365 the test was positive 😊

Congratulations 💖💖💖

Optimistic66 · 11/03/2024 13:46

Can I join?

I'm waiting for my period to start letrozole 2.5mg - i don't seem to ovulate regularly (maybe a couple times a year!)

Looking forward to be in with a chance to actually fall pregnant - so tired of no BBT rise or positive OPKs. Is anyone else doing a trigger shot?

Dija89 · 11/03/2024 13:43

@Daydreaming91 yep this was my 3rd cycle of 5mg . My 1st cycle they monitored me and they were happy with how I responded. So they gave me another 5 months and just follow the same protocol as cycle one. I didn’t bbt or use any ovulation strips we just dtd everyday after my last letrozole pill. My main symptom was very very very sore breasts. It gets very unbearable sometimes

Daydreaming91 · 11/03/2024 13:25

@Dija89 I hope it eases for you! Fingers crossed for some slightly warmer weather too.

It's nice to hear that the medication works, was this your 3rd cycle?

Dija89 · 11/03/2024 11:47

@Daydreaming91 just feeling nausea . And my breast have been in pain for the last 2 weeks. Esp when it gets cold 😒

Daydreaming91 · 11/03/2024 09:49

@Dija89 Congratulations! Hope you are feeling ok!

@Angelselevenx I have a follicle scan Friday, I think this will be just to check the dose has done it's thing again. I'm on my last tablet today, I've not felt as bad this time round but the hot sweats have been worse! I'm going to start testing Wednesday I think. I'm away next week for 3 days so worried we will miss our peak window

Dija89 · 11/03/2024 09:37

@Loz365 the test was positive 😊

TTC Active Letrozole Thread
Angelselevenx · 11/03/2024 09:27

@Daydreaming91 no I don't have any scans or tests this month, do you?

CD8 and started testing LH now as I have no idea if it'll bring my ovulation day forward!

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Daydreaming91 · 07/03/2024 17:15

@Loz365 thank you, haha that's exactly what my brain is trying to tell me! Hope you are doing ok!

@Angelselevenx ah good luck to you too! We can try and keep each other sane with the 2 week wait. Do you have any scans or bloods this cycle? My ovulation tends to be around the same time too

Angelselevenx · 07/03/2024 15:55

And the mood swings!? @Loz365 @Daydreaming91 that hit me this morning but seems to have gone now!

Good luck with starting let @Daydreaming91 we will be in similar stages as I'm only on day 3, I normally O around CD18-23 so I'm not sure how much it'll differ on the medication

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Loz365 · 07/03/2024 15:30

@Angelselevenx yep still taking them, I've googled it and looks like they're safe to continue.
Oh yea the night sweats were bad! It took me ages to work out it was the medication, I thought I was ill 🤣

@Daydreaming91 good luck! I always told myself at least if I had side effects it meant it was working 😂

Daydreaming91 · 07/03/2024 15:12

Hi everyone,

Hope you are keeping ok!

Ready to start my official first cycle of letrozole later, I'm taking the tablets at night too to try and minimise side effects. They made me so anxious last time so hoping I cope better this round.

The hot sweats are on another level 😂

Angelselevenx · 07/03/2024 07:55

@Loz365 that's interesting! Are you still taking them now?

How's everyone else doing? Day 3 of Let today. No one warned me of the hot sweats 😂

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Loz365 · 06/03/2024 10:10

@Angelselevenx I have PCOS so I'm taking inositol, my fertility clinic recommended it and it did seem to regulate my cycles even before I started letrozole. I also took vitamin D, folic acid and coq10. No idea if the last one made a difference but continued taking them all just in case 😅

Angelselevenx · 06/03/2024 09:45

@Loz365 I've had a few hot sweats but nothing too bad! 🤞🏼 I'm hoping it brings O a bit earlier but I doubt it.

Did you take any vitamins? I'm on the pregnacare conception max tablets and have been for the last month (before that was wild nutrition) so I don't know whether to keep going on the pregnacare tablets.

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Loz365 · 06/03/2024 09:02

@Angelselevenx exciting! Did you notice any side effects?

@Dija89 yes I have had 7 cycles on letrozole over the past 2 years and always ovulated once they got the dose right. Keeping everything crossed for you!! 🙏

Dija89 · 06/03/2024 08:47

@Loz365 yesh you are righter only testing is going to give me the answer.
my doctor was adamant that I would ovulate on all 6 cycles hence they said to me they don’t need to monitor me, they said it’s very very rare that the medication would just stop working especially within months. They said you ovulated beautifully twice. I might wait till Friday and take a test. Wish me luck xxxx

Angelselevenx · 06/03/2024 07:11

Started my first round of Letrozole last night, I took it at night to try and stop the size effects and seems to have worked.

@Loz365 look at that test!! 😍 just amazing. Best of luck for yours can in two weeks let us know how you get on!

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Loz365 · 06/03/2024 06:38

@Dija89 I would think it's more likely that you keep ovulating every cycle with the letrozole but I guess there's always a chance you hadn't.
I know how you feel, it's all that uncertainty and unknowns, TTC is so hard 😔
I always found that testing at least gave me an answer so I knew either way

Dija89 · 06/03/2024 04:10

@Loz365 awww congratulations darling. I hope it all goes well.
mom just so scared to test just in case it’s negative 😔
but I know I have to test. I hate the fact that I didn’t check if i ovulated this month(the month where I havnt got my period yet) but I know I got ovulation pains.
I guess there is 2 things

  1. I ovulated and am pregnant 2) I didn’t ovulate so no period . do you think it’s likely to ovulate on 2 cycles and then not ovulate on the next cycle 😐
Loz365 · 05/03/2024 23:00

@Daydreaming91 thanks! So pleased letrozole worked for you, took us 3 cycles to get this positive so fingers crossed for you!

@Dija89 letrozole always worked for me and I had fairly regular and short cycles with it. I would definitely be testing!!

I think I finally got my dye stealer today. Never got that far with the MC so hoping it's a good sign 🙏

TTC Active Letrozole Thread
Dija89 · 05/03/2024 20:53

Hi guys so glad I found this thread.
just a background I was diagnosed with pcos at a very young age due to irregular periods. The longest I went without a period was 6 months.

fast forward now 34 and have been trying for nearly 2 years. I am under a fertility hospital now. They did blood test, hsg X-ray to check if my tubes were blocked, all test came out good

hubby had an SA analysis and all was fine so they gave me 5 mg letrozole in December . I had to take provera to kick start my period. Anyway I took letrozole from cd 2-6 went in for a scan on cd 9 and then cd 12 and I had one dominant follicle , the doctor told me to baby dance and then come in for a progesterone blood test to see if I ovulated . My result was 34nmol . Anyway I didn’t conceive that cycle and for the first time in my life I had a 30 day cycle.
now onto 2nd cycle I had to go for a baseline scan to check that there wasn’t any cyst on ovaries and again the doctor gave me 5 mg of letrozle but this time they gave me 5 months in total and said I didn’t need monitoring as they were happy how I responded to the medication and so gave me 6 months in total. So cycle 2 I took the the letrozole for 5 days has no scanning done but I got a progesterone test done privately on cd 21 and the result was a whooping 79nmol. However I came on my period on cd 29. Now cycle 3 of letrozole took the same dose for 5 days . I had same ovulation pains as cycle 1 and 2 . This time I didn’t get a private blood test done as my doctors told me you will ovulate again and again on letrozole. Now I am cd35 and no sign of period. I havnt taken a test because I don’t want to break my heart. The only symptom I’m getting is a slight stitch pain on left side and more painful when Baby dancing. And my nipples are very sore especially when i am cold sorry tmi.
so my question is do you think I ovulated this month and just take a test or wait it out till Sunday. I don’t know what my natural cycle is as my periods were very irregular before I took letrozole. Looking foward to some replies xxxx