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Conception

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Original poster

Autoimmune conditions, NK cells, recurrent miscarriages?

36 replies

Daniki · 08/12/2022 19:50

Hey ladies,

Just wondering if anyone with any auto immune conditions is having trouble conceiving or recurrent miscarriages?

My first pregnancy in 2020 was successful and I had my DS in April last year.

In July we decided to try again and I got pregnant straight away but miscarried at 8 weeks. I got pregnant again next cycle and miscarried at 9 weeks.

Iv been getting acupuncture and the lady ,who was also a nurse for 20 years , mentioned about natural killer cells and how in some people they can actually attack the fetus as if it's a foreign body and maybe that's what's happening to me? I have ulcerative colitis so my immune system is already out of whack.

Thinking back to my first pregnancy I was actually on steroids and humira for the most part, definitely the first 20 weeks anyway, so maybe that's why it was successful?

Has anyone been through anything similar and has any success stories? I'm losing all hope and can't go through another loss, I only miscarried last week and it's really shook me 😢

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Original poster
Daniki · 12/05/2023 10:21

@AllIwantforChristmas22 thanks for reply! I kind of thought as much 😂 I don't have much hope tbh but I'm ok and I'm a good frame ready for next cycle 🙈😂

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AllIwantforChristmas22 · 12/05/2023 10:11

@Daniki sorry to hear. It’s not over until you get your period.

progesterone in my experience does not affect line progression. It progressed nicely with my rainbow pregnancy, and baby is 19 months now.

Original poster
Daniki · 11/05/2023 16:16

Hi ladies, how are you all? Hopefully someone sees this but iv such a silly question.

So since the last time I posted I went and seen a specialist and she gave me prescription for progesterone. Aspirin & steroids to start as soon as I became pregnant again. On Monday gone by I tested at 9dpo and got a very faint line, tested again the next day and it was the same. I started the script anyway as wanted to give this pregnancy the best chance possible. Have been testing daily and I have had no progession, possibly even fainter tests. Such a faint test this morning and I'm 12dpo today. Didn't even bother taking the meds as I'm assuming I'm having a chemical. 😥

My silly question which I'm only asking to give myself hope, wouldn't the progesterone be affecting my levels and maybe that's why there is no progression? 🫣

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Original poster
Daniki · 09/12/2022 10:21

Can I just say thank you all for your replies you have truly gave me hope and it has made my day! 🥰

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Daffodil21 · 09/12/2022 10:17

Oh I also did acupuncture too. Cured my fear of needles 😅

Daffodil21 · 09/12/2022 10:17

@Daniki I've just popped you a PM X

AllIwantforChristmas22 · 09/12/2022 10:11

Re money I have spent ££££ on acupuncture, vitamins, chinese herbs, private consultants and private tests and it was all worth it. A million times! Apart from the £50 chinese tea that made me vomit!

AllIwantforChristmas22 · 09/12/2022 10:10

@Daniki also 5mg.

good luck! Remember you have one baby, so your body can carry a pregnancy to term. There is no reason to believe you can’t do that again, maybe you just need the right medical support (I have an older DC too).

Th10 · 09/12/2022 10:08

@Daniki Ah, it does doesn’t it! 😆 well, good luck on your journey! X

Original poster
Daniki · 09/12/2022 10:02

@Th10 thanks, you too! Hopefully they will see me In The clinic but it’s the same criteria here it needs to be 3 Mc.
must look up private clinics and see. Waiting to drawdown mortgage aswell at the minute so money is tight—it all happens at the one time 🥴

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Original poster
Daniki · 09/12/2022 10:00

@Daffodil21 i did see this thread actually which gave me a lot of food for thought! Considering I was on steroids and humira for my first successful pregnancy (for my colitis rather than pregnancy) it all makes sense, I’m just afraid I won’t be taken seriously when I bring it up 🥴

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Th10 · 09/12/2022 10:00

Hi, how have you been since, are you trying/had C a successful pregnancy ?

Th10 · 09/12/2022 09:59

@Daniki Thank you, I am so sorry for your loss too! It’s frustrating when you now know something can be done! I went to my GP yesterday, and they said it’s not until 3 MC that they refer to the Recurrent MC unit. I’ve booked an appointment with the Recurrent MC Clinic in London, it is expensive, but its given me hope, but no availability until January. I hope all goes well for you!

Original poster
Daniki · 09/12/2022 09:59

@AllIwantforChristmas22 im on 5mg folic acid and have been since my pregnancy/1st miscarriage. What dose were you taking? i’m going to pick up aspirin myself and just start taking it that’s what my acupuncture lady recommended also.
i emailed my (Gastro) consultant office also but not sure if they would prescribe anything but worth a shot!
think we’re going to take a break for a 2-3 months my heads all over the place still

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Daffodil21 · 09/12/2022 09:56

Hi,

I had 3 mcs and suspect an autoimmune condition/NK cells (but not confirmed). I had steroid treatment and progesterone in my fourth and successful pregnancy.

Have you seen this thread?

Immune/NK cells - pred thread 30 www.mumsnet.com/Talk/conception/4626382-immunenk-cells-pred-thread-30

An immense amount of support and knowledge on there

Wishing you all the best!

AllIwantforChristmas22 · 09/12/2022 09:55

@Daniki the waiting list for miscarriage clinic is very very long too. I waited 6 months for my first appointment which was a phone call!! Thankfully I could cancel it as I was pregnant with my rainbow baby. I encourage you to get progesterone prescription before you fall pregnant again. Also I took 100mg aspirin not a small dose, and high dose folic acid. You don’t need a prescription for the aspirin but for high dose folic acid. And obviously take another pregnancy vitamin too.

Original poster
Daniki · 09/12/2022 09:51

@AllIwantforChristmas22 yes that's my fear that it will be too late 😢 iv emailed my maternity hosp to see if I can meet someone from the miscarriage clinic so hopefully hear back but it's usually from 3 miscarriage you're referred there. Glad to hear you've got your rainbow baby 🤗

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AllIwantforChristmas22 · 09/12/2022 09:50

@Th10 I had the same issue and was also exactly advised of this. I got the progesterone from a private place too.

Original poster
Daniki · 09/12/2022 09:49

@Th10 I'm so sorry you had a loss at 21 weeks that must of been so hard 😭 I feel like that's the same route I'm going to go down that I won't really be listened to and my GP already has said he's not too sure on the protocols so he's not comfortable prescribing which is fair enough. Did you go to a fertility clinic?
I was thinking of starting to take half dose of aspirin daily anyway without a prescription!

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AllIwantforChristmas22 · 09/12/2022 09:49

Progesterone from heartbeat is too late! I had to take it from ovulation. After three MC finally have my beautiful rainbow baby. Like a PP I had to take high dose folic acid, aspirin, progesterone and I also took blood thinners. Please find info on progesterone on Tommy’s website and show it to your GP.

Th10 · 09/12/2022 09:44

@Daniki Hi, after my first miscarriage at 21 weeks the autopsy found that I had antinuclear antibodies and may have contributed to the mc, I was told that during my next pregnancy I would be given aspirin from 12 weeks. I found out I was pregnant again but mc at 6weeks, I then went to my GP but they said they wouldn’t give me anything earlier then 12w because that’s what had been stated by the consultant. But I went to a private clinic and been told they’d put me on aspirin progesterone and a low weight heparin as soon as I get pregnant next time. I hope that helps? My GP wasn’t to helpful but I think going to a private clinic for advise gave me hope

Original poster
Daniki · 09/12/2022 09:13

@LBF2020 hard to say but defo worthwhile checking with your specialist anyway! It’s so hard to know what to do, I’m finding it very hard to deal with the anxiousness of where to go next or what will happen with a next pregnancy.
we’ve decided to stop trying for 3 months and going to give these holistic medicines the lady I’m seeing recommended. I don’t normally pass much heed on holistic remedies but can’t see the harm!

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LBF2020 · 09/12/2022 09:09

@Daniki I rang to let the team know I had stopped (I just assumed that was what I had to do) the specialist nurse said I could actually continue to take it and stop in the third trimester. She also mentioned that the increase in estrogen can help alleviate symptoms. I do have enough injections to get me through to 12 weeks so I wonder if I should continue with these (even though I've been off for a while?)

I also have a Prolactin secreting tumour which I think set off my anky spon. Since the tumour has been treated my back has been a lot better. Now I'm pregnant I have had to stop the medication for that too 😭 I have been booked in to antenatal clinic with my endocrinologist.

I do really feel for you, it's so hard to know what is best and I'm sorry for your loss. I have found the specialist nurses really helpful, so it's definitely worth checking with them.

Original poster
Daniki · 09/12/2022 08:55

@Twinklenoseblows I did actually come across one of them actually! I'm Irish tho so no access to that doctor I seen a lot of them talking about! 🥴
Wouldn't even have a clue where to start with private doctor here. The miscarriage clinic in my maternity hospital only sees you after 3 miscarriages which is harsh I feel 🙈

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