Anyone had any luck with Letrozole?!

@Alexis7890 i can call tomorrow but I feel like they’ll say to wait a few more days. My cycle is never longer than 34 days, there were no dominant follicles, I had no signs of ovulation and I’ve had no PMS symptoms so it feels obvious to me that it hasn’t worked 😭

@Hoping43 that’s rubbish! Is there anyone you can speak to tomorrow? Or will they just say wait for your period to naturally come?

@Alexis7890 No they didn’t see anything. They just said estrogen was coming from somewhere because my lining had thickened so they concluded that they missed it but I was never convinced and seems like I was right!

@Hoping43 did they see a follicle that looked like it was going to ovulate? I take provera for 5 days then period starts 2-3 days later, i was told I can start taking it anytime after CD22 so then can get cracking with the next cycle and try 5mg

@Alexis7890 how long did the provera take to work? I’m so anxious that I’m just in limbo wasting time 😭it’s causing me so much stress

@Alexis7890 No they haven’t mentioned it at all. Last conversation I had with the consultant was that I had ovulated between scans and they missed it because my lining had thickened to 13.7mm from 8.7mm but I was never convinced by it. Now I feel stressed that I’m just wasting more time and when is it ever going to come 😩 x

@Hoping43 that’s very different to our clinic, letrozole failed and as soon as they confirmed it failed around day 21 I was given a prescription for provera to start taking to be able to start a new cycle at a new dosage. Have they mentioned anything like that to you?

@Victoriaspa i have to ring back on CD39. I’m guessing ultimately the dose wasn’t right but obviously can’t move forward with anything until my period comes. So don’t know how long they will leave my in this limbo or when/how my period will eventually come!

@Victoriaspa no it didn’t. Im
on CD 37 which is my longest cycle and I’m not pregnant so really feels like it’s missed everything up. I’ve never missed a period before 🙁

Hi. Please can I join this thread? We have been TTC our third baby for 16 months after no problems conceiving our first two. I have just finished my first round of letrozole though it’s believed I ovulate naturally as my cycles are 28-34 days but told it can help even with a small degree of irregularity.

anyway, it hasn’t been a great success as I had four scans between days 9-21 and they never saw a dominant follicle. However, my lining has thickened in line with with an ovulatory cycle so they are saying they think I did ovulate but between scans and it was missed. I don’t feel convinced! Waiting for my period now. If it doesn’t come tomorrow I can have my dose increased so hoping and praying it holds off a bit longer! X

@Victoriaspa We tried for about a year without medication. Then about a year with letrozole and metformin. Blood tests determined that my wife wasn't ovulating successfully with letrozole alone so then her doctor recommended adding the trigger shot with the max dose of letrozole. I have read many other trigger shot success stories on this site too.

@Victoriaspa it is a hCG injection that "triggers" ovulation. There are a few brands I think, but we used Ovidrel.

We finally got our BFP after using letrozole and a trigger shot! My wife had taken letrozole for about a year, but it was our third cycle using the trigger shot with it that we got our BFP. Currently 17 weeks!

Yes! I tried clomid and tamoxifen, and neither made me ovulate. Tried letrozole as a least ditch attempt before IVF (was waiting for my 30th birthday as that was the Criteria in my area for now ivf). 3 rounds of letrozole and we fell pregnant with my beautiful little boy - after 3 years trying it felt like an absolute miracle!

I have just began letrozole again for baby number 2.

happy to try and help with any questions x

About 18 months. So the doctor thought perhaps I was only ovulating about 7 times a year based on the length of my periods. They did say they didn't see why I wouldn't conceive myself naturally if I kept trying, but by that time I just wanted to try something.

Yes, me!!

I'll give you abit of background (I remember I wanted to hear success stories at the time too!)

At the time I was 33, PCOS so although I was ovulating (most months) it was always quite late so my cycles ranged from 35 days to 55-60 days. I was told Letrizole would hopefully shorten my cycles giving me more chances to ovulate a year.

So I was put on 2.5mg, and it worked first time. I was not expecting it to so was very shocked. I ovulated on cycle day 15, which was the earliest I had ever ovulated. I had a scan on cycle day 10 which showed a follicle at like 16mm (i think) and so I was told you "do the deed" during the next week. I think we did it cycle day 10,12,14.

Side effects: I was really nervous about this, as had heard stories about cramps, hot flushes and headaches however I read somewhere (on here probz) to take your tablet at night time and you'll sleep through it and I never had any side effects whatsoever so taking it at night time worked for me. Although aware I was on a low dose.

Hope it all goes well for you, fingers crossed! We are considering taking it again for our second, but will leave it another couple of months and then see about getting another prescription.

Yes, me! I conceived my 16 month DS on letrozole on 7.5mg. This was after 3 failed rounds of clomid and 2 non starters with lower doses of letrozole - the only time I ovulated was on the 7.5mg.

We also started the supplement regimen in 'It starts with the egg', so I took inositol, Co-q10 and some other weird and wonderful stuff. No idea if it actually helped but it got us to our goal.

Good luck!

@BeatAroundTheBush thank you, he said it’s unlikely to work for me with my hormone levels. I was diagnosed with PCOS years ago and very rarely have a natural period so he was setting my expectations that I’ll likely need a high dose or injectables as the hormones are so unbalanced but you never know!