Recurrent Chemical Pregnancies, anyone seen a GP?

Hey all, I hope you don't mind me joining.

I have started some private miscarriage tests after 2 miscarriages in 6 months (May and November 2020) - testing thyroid, autoantibody, genetic thrombophillia, thromboelastogram and antiphospholipid.

I have to have one final comparison test for antiphospholipid shortly but due to a minor accident there is a good chance I could be pregnant this month (the second tests cannot be taken if pregnant).

Has this happened to anyone else? Can they savour any of the results from the first round? I would have thought some of the tests are complete given it's only the antiphospholipid which is taken a second time.

Any advice would be appreciated!

Thanks

@blackcurrantqueen
I have children too, i dont know if there is a problem or just bad luck 🤷‍♀️ xx

Hello ladies
I hope you don't mind me joining your thread
I am also seeking answers after my fourth chemical pregnancy
Currently waiting on a clinic appt for the recurrent MC clinic at my local hospital , I have had my bloods done as has my partner (some genetics bloods)
I have tried to look into private clinics but struggled to find anywhere this specialist?
I looked for a way to find out about the natural killer cells clinic in Coventry but I couldn't find any details, I'm assuming it is maybe currently closed
If my local hospital tests show nothing and they are unwilling to prescribe progesterone or blood thinners then I think I will ask for a Tommy's referral
I have one DD who is nearly 2, had an emergency c section with her so wonder if that has anything to do with it

Xx

@Icklemissgem try them, they're not awful at all. You just put put them in and then the only thing is that some residue/wax might run out which is a bit annoying but to be expected. Unfortunately it didn't do anything for me.
Again, I can suggest reading up on the CERM trial and possibly contacting Tommy's directly. 🤞🏼

@MgW1 I think just because it's hormonal and also because there pessaries you have to insert twice a day and it's just given me the heebie jeebies, also if this doesn't work feel like I have nothing else left to try.

I hope your referral comes through quickly 🤞🏻

@choccrumpet sorry to hear about your losses sounds like we're in the same position as I've had 3 also 😞
I hope you get seen soon 🤞🏻

Hi everyone, I've had 3 chemical pregnancies and have been referred to a specialist by my GP but no idea how long the referral will take. I asked my GP about aspirin and she couldn't prescribe it but heard of specialists prescribing it. I did my own research and decided to try aspirin this cycle from my fertile week as there is nothing else I can do. My period is late at the moment but not yet sure why. I've also got a pelvic ultrasound booked in a weeks time to make sure everything is okay. There was nothing else my GP could do so we decided to keep trying and hope we are successful before the referral comes through.

@Icklemissgem
Hi there
Hope your ok , all sounds v.stressful. i have been referred but not been seen yet , informed its approx 13 week wait so will see what happens. What are the side effects of the pessaries ? Is it that your worried about or because its a hormone ?

Hi All
Hope nobody minds me jumping on this post. I have been reading through the thread and you are all so lovely and supportive, I am so sorry for everyone's losses.
I have now had 3 chemical pregnancies in a row and am currently 6dpo to see what this cycle brings - I am extremely nervous.
I had to self refer to a private clinic as my GP wouldn't help me as I already have a healthy 3 year old girl. I have been prescribed cyclogest pessaries to starting using when I next get a BFP but I am scared to use them as they don't sound pleasant 🥺 all my tests came back fine and the consultant just said try these and see as they won't do any harm 🤷‍♀️

@NoCallerID
I am sure it will do and I hope it works out for you too, good luck and i hope you have a healthy pregnancy v.soon!

@MgW1 Yes you'll have to be referred through your GP, stating Tommy's at St Mary’s in Manchester. If they need a name on it, I think it's Prof Myers. You can also contact Tommy's directly and ask what the process is. I had to do this as my GP wouldn't refer me after 2 MCs and they said they accept after 2 and I think my GP had to put something on the referral... I really hope it all works out for you.

@NoCallerID
Im in york.
How do i get referred ? G.P ? Can travel to manchester. I am so glad you have got the appropriate support and treatment. Its so stressful.

@MgW1 I suppose it is much lower. But since it's bacteria it can be caused by other things as well. But of course it could be something very simple. Tommy's do all sorts of tests with the initial blood test including testing for blood clotting disorders which isn't done by GPs (not sure if they offer it in local RMCs). They also have a few medical research trials going which they could suggest to you if they find you meet the criteria, which otherwise you wouldn't be able to take part in.
My husband and I have had karyotyping done too due to our TFMR baby having a chromosomal disorder. They did not check my progesterone but I was given a prescription for it anyway, to take from the next positive test. Unfortunately this didn't help and I had the 4th loss on progesterone. There's a Tommy's Facebook community which is great and you might get more help in terms of what's actually tested for in the beginning, I'm sorry I don't remember everything but it all came back fine (thyroid, kidneys, liver, blood clotting etc...)
Where abouts are you based? I'm under Professor Quenby in Coventry and she's absolutely fantastic. Tommy's have other clinics in Birmingham, Manchester and London too.

@NoCallerID
Natural miscarriages every time so i think the risk of infections is lower. Did they do all the other tests at tommys ? To check for blood and progesterone etc ? I put mine down to stress after 1st miscarriage , but i dont know. Strange i have never had one before , had 2 children and then had 3 in a row. Did you have any symptoms of CE?

@MgW1 I'm soo sorry. It's awful going through this.

Did you have a natural/medically managed miscarriage? Any intervention or D&C?

The co-amoxiclav was to prevent an infection after the manual vacuum aspiration.

For the chronic endometritis (make sure it doesn't autocorrect to endometriosis if you email your GP on your phone...) it was 100mg Doxycycline twice a day for 14 days starting with the first day of the period. It was a crap two weeks for me - I felt incredibly down and struggled with my stomach, both which are side effects of Doxy, it's definitely no walk in the park. Unless you have a very very compassionate GP who is willing to bend the rules it's unlikely that they would prescribe this. CE isn't tested for in the UK yet as there is no NHS guidelines / approval on it. We tried to go private due to the 50/50 risk of getting the placebo in the trial but no one would do it. That's the whole reason for the trial - to get this treatment approved on the NHS by showing that Doxy is effective.
You can read up on it or even send it your GP, it's called CERM Trial.
Doxy is already being used in other countries with (partly) privately paid for health care despite there not being a lot of research into it.

Was co - amoxiclav for C.E?
I think i have been on that before for something but not recently

@NoCallerID
I shall speak to my G.P and ask if it is possible and how it can be ruled out. I had a miscarriage at the end of my first trimester and then 2 early mc's.....very stressful. No i meant treatment for Chonic endemetriosis, il see what my doc says thank you 💕

Nope, taking that back... just checked my notes if was co-amoxiclav 625mg...

@MgW1 Sorry, I think you meant the one week course after the MVA, no that wasn't Doxy, I think it was metronidazole.

@MgW1 yes, it's either the Doxycycline or the placebo, so I had the doxy. It's a blind trial so no one knows what you're given but due to the side effects (and me opening the capsules because I needed to try and find out whether I had the real stuff or would have to revert to plan B) I knew I had the actual drug.

@NoCallerID
Were you prescribed doxycycline?

@MgW1 I had several scans after the termination due to heavy bleeding. I was fobbed off at first and told the remaining products would clear themselves. I continued to bleed and pass clots and they eventually did an MVA to remove the tissue and gave a weeks course of antibiotics after that. It was too late at that point and the antibiotics I was given to 'prevent infection' were the wrong ones for this kind of infection anyway. I've since had another scan after my 3rd miscarriage (privately in my home country with a specialist consultant) because I was worried about scarring from the procedure being the cause for the miscarriages. This all came back fine and the condition I was eventually diagnosed with can only be diagnosed with a biopsy, it can't be seen on scans or detected in blood tests.

@NoCallerID
Wow I bet you couldnt believe it and thank fully you have got to the bottom. Just read up about it now ans it can be nasty if untreated. Dis you have a pelvic scan after mc? I have had a pelvic scan and im going for another in a few weeks time ( internal for a closer look) so will ask to make sure uterus is clear.

@MgW1 they only managed to find out because I was willing to take part in a medical trial. I also have one living child and never had issued conceiving. We had a termination for medical reasons last year and after this the early losses started (4 of them within 6 months). It turned out that I have a bacterial infection called chronic endometritis which was either caused by the retained placenta after the termination or the follow up procedure to remove the placenta. Most women don't have any symptoms so never know they have it. It was only possible to be diagnosed through Tommy's due to them running the trial. I got medication for two weeks (you either get antibiotics or a placebo as part of the trial - I'm 100% sure I got the antibiotics) and then had another biopsy and now we're good to go again. We decided not to waste any time because we've already lost a year and wanted a small age gap for our children. (It's now already 1.5 years more than we wanted...).

@NoCallerID
Its a referral locally not through Tommys.
We already have 2 children. I dont know if its bad luck or what but too anxious to try again just yet, will wait a few months and see.
That is a positive outcome for you , has it been quick for them to identify a cause? Iv had my thyroid checked and that was normal.