Immune/NK issues - aka Pred Thread no. 22!

Hi @Anatrina. I decided to not go with Mr S after my last miscarriage with him (I won't go into it again but it's all written down here somewhere!) I just chose an IVF clinic who sort of believed in immune therapy etc and their protocol was very similar to that of Mr S. Maybe even more conservative. You'd need them to be happy with the drugs you were taking I suppose. I started on the pred 2 days before embryo transfer I think but I'd already had intralipids before (twice before and then twice after BFP). I hope that helps. Are you already with a clinic? Where are you based?

YES @Chickjen! YESSSSSS!!!! XXX

@KittyKatSmile Can I ask how your immune treatment works with ivf? When did you start taking the drugs etc? Just wondering how mr s plan would work alongside an ivf cycle and if there would be any need to even tell him about it?!

@Chickjen I am so so happy for you!! Sending you hugs!!! ❤️❤️❤️

Awwww @Chickjen and little chicken, I'm so over the moon for you both. It's a worrying time but just try to keep calm and remember the mantra. Once you're through you'll look back on it and think the time flew...

Cutie and I sending our best wishes x

@Chickjen So pleased to hear your amazing news!!!

@Chickjen congratulations, so happy for you! Keep growing sticky bean!

@Chickjen yay so happy for you! And I think measuring ahead is a really good sign. When is your next scan/intralipids?

Thank you everyone, I am flattered by the support, and very sorry for the moaning over the last few weeks! ❤️❤️❤️
@Pop1234 by LMP it is 6.5 weeks but my cycle is less than 28 days so everything is measuring ahead at 7 weeks. I have only got this far once before size wise.
@KittyKatSmile little chicken 😍 I love it! I am going to call it that from now on 😀
Keeping everything crossed for the next couple of weeks 🙈

@Chickjen I’m so happy for you, I hope this is take home baby. Good luck lovely Xx

@Chickjen Ahhhhh amazing!!! I have been checking all morning waiting for your post and crossing my fingers 😍👏🏽 Sooo pleased for you!! Believe it because it’s true, live in the moment & don’t worry about what you can’t control xx

@Chickjen That is absolutely fantastic! Congratulations!

@Chickjen I knew it! I bloody knew it! God I'm so freaking chuffed for you! It will be utterly terrifying for the next 6 weeks but stick with the mantra 'today, I am pregnant'

So much love to you and little chicken xx

@Chickjen That is wonderful news!!! X

@Chickjen amazing, so glad you got good news! How many weeks? Are you 6 now?

Oh my god, oh my god, oh my god! There is a baby with a heartbeat! I can't tell you how floored I am, I was so so convinced there was no hope.
There is some bleeding near the baby so I need to double up on cyclogest and start nifedipine, whatever that is, so not quite out of the woods yet, but this is the furthest Ive been in about 2 years 😱

@MrsMargot It was £1,130 for two injections to be taken two weeks apart. After a MMC on the usual treatment (pred, intralipids, progesterone) the doctor gave me intralipids and then tested again for NK cells - they'd actually risen not fallen. I apparently come in the 10% of women who intralipids don't work for.

There's a national shortage of humira at the moment, so it was very much just find it where you can - usually places like Lloyd's online and Pharmacy2u stock it, but they can't get it from their supplier at the moment so i just had to suck up the cost rather than shop around.

@Chickjen thinking of you and hoping you get an amazing surprise. Which day is it again? Or don't say if you prefer not to (I could of course be less lazy and look it up myself!) Much love x

@Wewin thanks, I do hope everything is ok and if not that we’ll fall pregnant on our first try and be successful with the new medication. What’s your treatment for NK cells? I’m seeing that it varies (Humira, lovenox, prednisone) and I’m wondering if I should have more medication. I just have prednisone, intralipid, progesterone and Levothyroxine. I plan to ask my doc if he thinks it’s worth throwing lovenox in too. GL I do hope you’ll report bfp next week!

@Chickjen I’ve noticed less bleeding too, probably because pregnancy is earlier and earlier and not much to pass?

Yay @ginandtonicformeplease you found some 🎉 I honestly felt nothing at all after taking it, I was convinced I had messed it up and the injection hadn't worked, and yet my TNF cells more than halved. I know you are taking for NK but if it can zap one without side effects why not the other 🍀

@zoe16 yes I am the same, the baby stops growing earlier and earlier but the actual mc happens later and later 😕 Plus I've noticed far lighter bleeding than expected too. After the last cp it only really lasted one day. It's something I plan to ask tomorrow assuming it's bad news and I don't forget!

@Wewin fingers crossed for you, let us know how you get on 😀

@ginandtonicformeplease would you mind telling me how much Humira costs? I am trying to put together potential costs so I have an idea what to expect. I know it is expensive I just do not know how much. Thank you!

I took my first dose of humira on Monday (after almost crying at the price of it!). I've been waiting for the side effects to kick in, but none so far. Just fingers crossed it's working 🤞

Zoe abd Chickjen praying all will be ok.

With my four losses, they’ve been:
5 weeks
4 weeks
6 weeks (TMR D&C)
4 weeks

I usually get pg first try. This is my first cycle on prednisone and progesterone from ovulation. It was also a super ovulation cycle. I do ‘feel’ we’ve caught again on first try even with prednisone. Will keep you posted. I was worried it would delay getting pg but hopefully not. 5dpo today.

@MrsMargot it is annoying! I found my d&c somewhat traumatic, I don’t know if it’s because it was my first pregnancy or all the side effects from the d&c, I was in a lot of pain afterwards.

@Chickjen yes mine have been ending earlier and earlier which I guess is the body responding faster each time because it recognizes what is going on. Although in my case the embryo stops growing but I have to wait a few weeks to miscarry. However, I’m not sure if it’s the medications particularly progesterone which tricks the body that it’s still pregnant? I hope your scan pleasantly surprises you!

@MairMum18 sounds like your sorted hopefully it does the trick

@MairMum18
I became pregnant after 3 cycles of pred but then miscarried.
Hydroxy was then added and after about another 5 cycles I was successful.

@Chickjen keeping everything crossed for you today x