Immune /natural killer cell treatment when ttc or pregnant (aka the 16th pred thread!)

Ah i see snoopy ! That sounds positive then.

With the SO scan Dr s asks when you normally ov and works from that so if you are day 14 he says 11-13 for scan. He ll then adjust it if the medd make u earlier.

I actually worry about shorter cycles (since my mc my ov is now 12/13 instead of 15/16). Both times i ve been preg have been from later ovs (DS was latest ov i ve had on day 18/19). My acu lady actually tries to get peoples cycle to have an ov btw 16-20 so the egg has time to fully mature and lining is ready. So who knows what is best but there is some study out there that found a huge variation (like day 8-25) and concluded it didn t affect preg rates ! But i know its hard not question these things.

hula sorry, OH is occupational health at work. Apparently the person who had my case previously had incorrectly put me in recuperative duties when it should have been restricted. I have to get a letter from Dr s about treatment and importance of staying calm but my new case manager used to be a midwife and she said she'd have no problem recommending I stay office based. She asked what my previous role had been and I said 'going to 999 calls' and she replied 'no no no no no, far too stressful' haha.

Quick question for those who have done SO, how do you know when to scan? Were your cycles always shorter? This long cycle is worrying me, even if I did eventually ovulate would the egg have been bad quality?

And thanks Hula too for all the info, sent my msg before seeing yours. Xx

Thanks everyone for making me feel so welcome and for sharing your experiences. It's a daunting journey to be starting on! Hi Tina - hopefully the preds won't affect us too much, fingers crossed it all works out for us all. I keep thinking that my age is massively against me but I am already blessed to have a gorgeous 2 and a half year old daughter - had her when I was 40 so there is hope!

Sunnyday that's great to hear, congratulations! Who knows if it was the Hydroxy, either way it's wonderful news and gives me hope that it can all work out. Take it easy and try to relax if you can xx

Evening ladies.

Thanks Rosa for your SO info, i ll def aim for a no later than day 10 scan next time and i m very glad we at least had dtd b4 (only once but at least still gives us a chance).

Welcome Tina and Lisa, sorry you find yourselves here. I know i found it pretty daunting with the idea of a whole load of meds esp during preg. I ve not had sucess yet but heres what meds i ve taken and how i ve found them:
Aspirin - no issue
Pred - mild insominia (harder to get to sleep, waking earlier), feeling a bit revved up (like 5cups of coffee - good for getting housework done !), no other probs but did mess my cycle (cycle after was only 2wks!) so have been too chicken to try again since.
Humira (4 injections) - was really scared about this one after reading data sheet but so far no noticeable issues.
Letrozole - no probs except maybe a bit more emotinal as came off.
Ovitrelle injection - no issue.

Good luck on your journeys.

Snoopy - is it work who want to talk about how your treatment is going ? Sounds odd they can ask about details and annoying they won t do it by email.

seeking I think it's really a huge positive you didn't miscarriage. Hopefully knowing you can rely on the treatment will ease some of the pressure. One challenge at a time, and you've conquered that one!

Hello to tina and lisa, so sorry you both find yourself here but we are a very supportive bunch.

Had a call from OH on the way home from work. Apparently they need to speak to me to ensure work have made the changes they recommended and see how the treatment is going. I explained I wasn't really free to speak and it might be easier to email me but they insisted it had to be done in the phone so I have an 'appointment' at 10am. Don't know where I'll find an empty office to speak to them and I'll have to tell them that I haven't even finished one cycle yet, not great eh?

Thank you ladies for you kind and supportive messages. Will keep you all posted about my progress and experience.

Hi Tina and Lisa,
Welcome. Sorry for your losses. I hope you find this group of extraordinary ladies as supportive and helpful as I have. Although we each have our own battles we are all in similar positions and have between us been through all sorts.
Good luck with your cycles ladies, I hope you get your bfps soon.

Hi everyone

I hope you don't mind me joining you all, I'm just about to start DrS treatment too (preds for 10 days from ovulation then lots of other things added to the mix if I'm lucky enough to get PG). Think I'm gonna ovulate in 3 or 4 days.

Have read through lots of the posts and it's wonderful to see how lovely and supportive you all are, it's such a horrible thing to go through. Like a mad roller coaster ride of ups and downs. I've suffered 3 miscarriages since September and at 42 I am so scared I'm running out of time. Nhs harshly told me I was too old for tests so we found the money to go see DrS. Wasn't sure I had time to wait for nhs anyway.

My Nk cells were 35 but in the tests the preds bring it down to 14 apparently. So fingers crossed. Not sure if that is a really high count or not! And if it all works out my older eggs could still let me down at any point but one step at a time...!

This thread has been so helpful to me with all of my worries and concerns. Scared of my cycle going all wrong and am getting a bit crazy obsessed with each cycle thinking it could be my last good egg at my age! The whole thing is driving me a bit mad I think...

Anyway, just wanted to say hi really and introduce myself. Sending positive thoughts to all xx

Also- other than my cycle blip, I've not had side effects from meds. But not been on them terribly long either!!

Hi Tina,

I got pregnant within 3 cycles, but miscarried again. The Pred messed up my cycle & so I skipped it on month two. I also have a history of catching quickly (3 pregnancies in 5 cycles). However, I have v high NK cells so it looks like I need stronger treatment. I'm now taking intralipids before even getting BFP! I think all our experiences vary a bit, but we get there in the end :) Good luck!

Hi Tina - I took 8 months on treatment to fall pregnant. I found pred tough with insomnia but manageable. I didn't get weight gain until after about 6 weeks but you don't care so much about symptoms at that point. Best of luck to you x

Hula - really hope you caught one by dtd early. I think that's what happened to me.. My first SO cycle was useless as I think I told you , on the second we dtd day 10- the day before day 11 scan and my mine were 26 , 16.5, 14&11- was told the last two were two small but the biggie would pop before injection had chance to work so v glad dtd before as assume that was 'the one'. Was told to do injection anyway and dtd day 12 and 13 incase it caught the 2nd biggest one. The drugs make your cycle shorter so I think good to dtd every 2nd day from day 8. I ALWAYS used to ov day 17 according to these predictor kits but think you need to put all that aside when going SO .. Everything crossed for you this month, or you'll be 3rd time lucky if not.
Hi everyone else x

Hi Tina.
I had no se at all! Was fine on it. I didn't get preg but that's due to another issue with DH.
Usually the side effects u mention are when ur on it long term like a few weeks/months.
Some of the ladies on here have had their cycle go wonky on it! I hope ur ok on it!

Hi all,

Looks like a lot of DR Shehatas patience on this thread and you ladies are much further along than I am. I'm on my first month of trying, just started my first pack of prednisolon and panicking a little as I've been reading horror stories about lack of sleep, weight gain and joint problems. Can I ask how quickly did you get pregnant once on the treatment? What are your experiences with prednisolon and the rest of the medications?

Thanks Snoopy I know it's not all bad. And really right now I'm not worrying too much. I know there is a way round it. To be honest I'm just relieved the treatment stopped me miscarrying so I have faith that it will work. I have to just accept the rest I guess.

hula how annoying. Hopefully you caught the egg/s though. Would it be possible to have the scan earlier next cycle if needed? Sorry, I'm so ignorant when it come to this super ovulation stuff.

seeking I know it's very hard but please try not to worry until you have all the information. I have a friend who had two girls with his wife and then she had a surprise third pregnancy. Despite a normal pregnancy his son almost died within twenty four hours of birth and tests revealed both he and his wife had balanced translocations. And yet they have two healthy girls and didn't have any idea there was anything wrong. I know this story is a bit doom and gloom but even with their complications they have had children.

oh i see seeking, i have everything crossed that it was a rare one off thing.....im sorry i know what it feels like to think u have maybe hit a brick wall and don't know where to go from. BUT we all always think worst case....and usually its not WORST case, it just means a change of plan...i don't know if that makes sense!

but when dh sperm was low i went into google frenzy mode and found stories of men needing surgery to extract sperm and there not being any there and it was TOTALLY not needed and worried me for no reason...i automatically jumped to worst case scenario and panicked HUGELY....its hard not to google! but before u have all the facts keep everything crossed. well I'm crossing them for u.....:)

Gosh Seeking sounds scary but i d try and stay away from dreaded google if u can until u have your results as u may be putting yourself thru unnecessary worry. Sending Hugs, the uncertainty must be horrible.

Thanks Trying - yep i think i must ov pretty soon after and at least we did dtd yesterday so prob was pretty well timed, dh will get an easy month this month ! I knew it would be tight to try and stretch scan to day 12 but with the weekend and work i had no choice. I would think the argc would be able to help your lining with such close monitoring, i think you can have oestrogen patches if your levels are low.

Oh that's crap Hula Hopefully though you've done enough to have caught the egg(s) any way. Rubbish that you won't know wether this dosage is corrector not though.

I know that if either of us are carriers of a translocation it doesn't necessarily mean that we're 100% out, but the issue the baby had was so rare -unbalanced robertsonian translocation with the same chromosome. Normally it's between 2 different ones. There are rare cases when carriers have both chromosomes fused which essentially means they will never produce 'normal' babies.
If either of us has a balanced translocation it means theoretically there's a 1/6 chance of normal pregnancy, 1/6 chance of same balanced translocation and 4/6 chance of chromosomal defect. It's scary!! Google is a scary place at times!

oh hula I'm sorry, u tend to be a quick ovulator when u get ur positive lh stick don't u?....hopefully 2 eggs came out and at least u DTD the other day....im sorry, will maybe take a few cycles to get things perfectly timed???.great ion the lining i only ever get to 7mm (more often 6) which i think is a problem I'm hoping argc addresses.....