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Immune /natural killer cell treatment when ttc or pregnant (aka the 16th pred thread!)

992 replies

sunnyday01 · 05/06/2015 19:22

This is a thread for those diagnosed with high or very high natural killer cells and trying to concieve or are pregnant and taking steroids/intralipids etc

Newcomers very welcome

OP posts:
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5
Tryingno1 · 02/07/2015 12:39

Hey guys
Hope everyone is ok!
Huka u must be in 2ww!
Determined when do u get bloods results?
Sunny hope ur hanging in there!
I'm feeling so normal and sup 5 weeks today. I have no symptoms it's really freaking me out. My scan feels like ages away :(

Drttc · 01/07/2015 21:05

I'll update my info!

Hopender- (38 yrs old) 7 miscarriages, one DS, pred, cycolgest, baby aspirin and intralipids. Baby boy born!

2nd trimester

Rosa (39yrs) - 3 MMC
(11.5, 6.5, 7.5). 6 months ttc on treatment. On complex programme for high NK, cytokines and thyroid antibodies (hydroxy, pred, intralipids)- had allergy to Humira. SO programme (16 Weeks)

1st trimester

Sunny (32 yrs)- high nk cells - hydroxy, pred intralipids - 3 mc (1 on treatment). (8/9weeks?)

Tryingno1 (31 yrs old)- 3 mc. Ttc since April 2012. 5.5 weeks, 9 weeks, 6 weeks. Ivf bfp this time as low sperm. Also High nk cells, pa1 mutation. C4/m2 mutation. Hla dq match and low LAD. (Last ones done by ivf clinic) on dex, asprin, metformin,clexane,hydroxy and Intralipids every 4 weeks till 16weeks (4 plus 5)

TTC

Hula2 (39 years) - one DS (took 18mns with low amh but no other probs), one MC at 9wks, ttc no 2 19 mns (12mns since last mc), low amh, borderline cytokines, high nks, on complex nk plan (pred, intralipids). Humira completed. SO cycle 1.

Drttc- (28 yrs old) 4 MCS, 1 on treatment (6 wks, 4wks 2 days, 5.5 weeks, 6 wks), very high NKC on complex treatment plan: hydroxy 2x day, 25 mg pred from ovulation, add cyclogest on bfp & Intralipids every 4 wks until 16 wks.

SeekingMiracles: 31.
4 mcs (sad) DEC'13 (5.5w), JUNE '14 (blighted ovum 7weeks), OCT '14 (Chem) JUNE '15 (9w).
High NK cells and ProThrombin gene variant.

WTTC

Determined123- awaiting (retest) results. 4mcs (2 on treatment).

Snoopy-high nk cells. 3mcs??

Tryingno1 · 01/07/2015 19:17

Baby smile

Hopender- (38 yrs old) 7 miscarriages, one DS, pred, cycolgest, baby aspirin and intralipids. Baby boy born!

2nd trimester

Rosa (39yrs) - 3 MMC
(11.5, 6.5, 7.5). 6 months ttc on treatment. On complex programme for high NK, cytokines and thyroid antibodies (hydroxy, pred, intralipids)- had allergy to Humira. SO programme (16 Weeks)

1st trimester

Sunny (32 yrs)- high nk cells - hydroxy, pred intralipids - 3 mc (1 on treatment). (8/9weeks?)

Tryingno1 (31 yrs old)- 3 mc. Ttc since April 2012. 5.5 weeks, 9 weeks, 6 weeks. Ivf bfp this time as low sperm. Also High nk cells, pa1 mutation. C4/m2 mutation. Hla dq match and low LAD. (Last ones done by ivf clinic) on dex, asprin, metformin,clexane,hydroxy and Intralipids every 4 weeks till 16weeks (4 plus 5)

TTC

Hula2 (39 years) - one DS (took 18mns with low amh but no other probs), one MC at 9wks, ttc no 2 19 mns (12mns since last mc), low amh, borderline cytokines, high nks, on complex nk plan (pred, intralipids). Humira completed. SO cycle 1.

Drttc- (28 yrs old) xx MCS (6 wks, 4wks 2 days, 5.5 weeks), very high NKC on complex treatment plan: hydroxy 2x day, 25 mg pred from ovulation, add cyclogest on bfp & Intralipids every 4 wks until 16 wks.

SeekingMiracles: 31.
4 mcs (sad) DEC'13 (5.5w), JUNE '14 (blighted ovum 7weeks), OCT '14 (Chem) JUNE '15 (9w).
High NK cells and ProThrombin gene variant.

WTTC

Determined123- awaiting (retest) results. 4mcs (2 on treatment).

Snoopy-high nk cells. 3mcs??

Tryingno1 · 01/07/2015 19:07

I hope it was ok given the shitty timing xxx

Tryingno1 · 01/07/2015 19:07

Seeking isn t ur bday today????

Happy bday!!! Actually no it was last wednesda? So sorry I forgot when u rem mine. I got my bfp that day but didn't log on as was too scared! Smile

Tryingno1 · 01/07/2015 19:04

Yeah rosa! She had a boy! Sounded a bit stressful has had placental abruption but baby was safe and sound as was she! Last we heard he was in neonatal ward but hopefully he's home now!

Seekingmiracles · 01/07/2015 18:59

Can't re-post the whole list with myself on so someone will ha rot add me on...

SeekingMiracles: 31.
4 mcs (Sad) DEC'13 (5.5w), JUNE '14 (blighted ovum 7weeks), OCT '14 (Chem) JUNE '15 (9w).
High NK cells and ProThrombin gene variant.

Rosa27 · 01/07/2015 18:57

WHAT???!!!! Hopender had her baby?! How did I miss that!! Amazing news Smile
Hope - I can't believe you're there already .. Hoping you're ok and loving your new wee one.

Trying - thanks for updating things. Crazy how much changed in just a couple of months ?! I'm 16 weeks if you're updating again (17 on Sat all going well). Sorry you've had a nightmare with intralipids.
Snoopy - hope you feel better when you're back into a routine and everything else then starts to fall into place too.
X

Tryingno1 · 01/07/2015 17:23

Swlondonnanny sorry not got urs please add if u lurking :)

Tryingno1 · 01/07/2015 17:11

Baby :)

Hopender- (38 yrs old) 7 miscarriages, one DS, pred, cycolgest, baby aspirin and intralipids. Baby boy born!

2nd trimester

Rosa (39yrs) - 3 MMC
(11.5, 6.5, 7.5). 6 months ttc on treatment. On complex programme for high NK, cytokines and thyroid antibodies (hydroxy, pred, intralipids)- had allergy to Humira. SO programme (? Weeks)

1st trimester

Sunny (32 yrs)- high nk cells - hydroxy, pred intralipids - 3 mc (1 on treatment). (8/9weeks?)

Tryingno1 (31 yrs old)- 3 mc. Ttc since April 2012. 5.5 weeks, 9 weeks, 6 weeks. Ivf bfp this time as low sperm. Also High nk cells, pa1 mutation. C4/m2 mutation. Hla dq match and low LAD. (Last ones done by ivf clinic) on dex, asprin, metformin,clexane,hydroxy and Intralipids every 4 weeks till 16weeks (4 plus 5)

TTC

Hula2 (39 years) - one DS (took 18mns with low amh but no other probs), one MC at 9wks, ttc no 2 19 mns (12mns since last mc), low amh, borderline cytokines, high nks, on complex nk plan (pred, intralipids). Humira completed. SO cycle 1.

Drttc- (28 yrs old) xx MCS (6 wks, 4wks 2 days, 5.5 weeks), very high NKC on complex treatment plan: hydroxy 2x day, 25 mg pred from ovulation, add cyclogest on bfp & Intralipids every 4 wks until 16 wks.

Seeking
?????

WTTC

Determined123- awaiting (retest) results. 4mcs (2 on treatment).

Snoopy-high nk cells. 3mcs??

I thought I would do this again. Seeking we don't have ur info. I hope I didn't make any upsetting mistakes? I think it's useful for the lurkers out there and might encourage them to join!

Also, I felt weird putting I was in first trimester? It feels too early to say that I wanted to put - just found out she has a bfp?! But that's a bit odd!

Xx

Tryingno1 · 01/07/2015 13:40

Thanks seeking that's v kind. It's sorted! I gave them a good teling off and my DH is leaving work early to get their last delivery. What a pain!

Got to work and had 2 bites of a brie sandwhich! Was harrased and not thinking! then went oh this is "gross" out loud when I realised I shouldn't be having brie and chose another one! Need to be careful And also less obvious!

Hi snoopy been thinking of u. Maybe work will be a good distraction for u? Are u back to ttc yet? Make sure u just do what feels comfortable for u. I hope they ease u in.

Snoopysimaginaryfriend · 01/07/2015 13:15

Hello everyone, just checking in to say hello and let you all know I'm still thinking of you all.

It doesn't seem to get any easier no matter where in the process you are, ttc, pregnant, waiting for scans.... The whole thing is heartbreaking.

trying I agree with the crystal ball idea, I'd go through this a dozen times if someone could tell me the thirteenth time would be my healthy, happy baby. It's the not knowing that is most painful to me.

I'm back at work on Saturday to do admin and then starting my Monday to Friday 8-4 office job. I'm relieved in the one hand but on the other I'm not relishing all the time at home alone that will bring.

Seekingmiracles · 01/07/2015 11:17

Oh no! What a nightmare!! Is it going to arrive in time?
If you get stuck I have loads of Fragmin, does the same job as Clexane. Could try and get it to you some how??

Tryingno1 · 01/07/2015 10:59

Agh! Cock up with delivery! I'm mega late for work need to leave like now! Need infusion on Friday and my clexane runs out tmrw!

Tryingno1 · 01/07/2015 10:06

I know it goes sooo slow doesn't it. But hopefully u will be busy making ur home beaut while it happens.

Waiting for my intralipids! Need to get into work wish they would hurry up!
No cramps or twinges today?! Slept really well too. Feeling fine. Trying not to obsses as what this means now!

Have a good sunny day everyone x

Seekingmiracles · 01/07/2015 09:03

Yeah I suppose in the grand scheme of things I fall quite quickly.. 4months of trying for pregnancies 1,2 &3 and 6 months for pg4. Seems like an age when you're actually going through it though. I'm hoping now with meds it might be sooner. I know eventually like you say,one will work in my favour but I'm so impatient. A crystal ball would be lovely!

Tryingno1 · 01/07/2015 07:41

Morning seeking. I'm going to try keep a lid on it today!

Aw it's so hard hearing other people's news, u sound like ur doing so well though. It will be you soon again, hopefully the house and puppy will keep you busy for a bit and before you know it you will be back on ttc. U get preg quite quickly don't u? I was thinking yest essentially it's just a numbers game-one of them will work out for us all its just a matter of when. So we all have to have hope that it's the next time and if not, the time after. I just wish I had a crystal ball that could tell us when that time was!

Seekingmiracles · 01/07/2015 07:35

Hope you feel better today Trying.... One day at a time is a much as you can do. Just try to keep yourself busy. Cyclogest def played havoc with my bowels, so all those twinges could well be that.
Hope you have a lovely holiday Hula, I hope it passes time quickly and ends with a happy bfp!

I'm ok thank you Trying, I just want tiger back to ttc and feel like I'm at least doing something.
One of the girls at work has found out she's pregnant... Very early Hmm she was very kind when she told me ( they all know my mc history) but I found it tough. It should be me Sad
Generally though I'm ok and feeling positive.

Tryingno1 · 01/07/2015 07:03

Haha hula, we are all a bit cuckoo I wouldn't worry! Great a holiday, Best thing to keep your mind busy
Have a good day everyone, thinking of u drtcc and seeking and hope ur both ok x

Hula2 · 30/06/2015 20:49

Hmmm sounds good might have to fall off the diary wagon and try one !

Yep lets hope these next couple of wks fly by. We re actually going on hol next week and loads to do up till then to keep me busy. Will have to test on hol, already did a hpt to see what it looks like after the trigger (am i wierd ? sometimes i feel like my own personal science project !!!), actually fainter than i thought but even tho they we re nt real it was strangely nice to see two rather than one line (i m definetly weird and need to get out more, ha ha !).

Tryingno1 · 30/06/2015 19:26

Great timing! I always find early
Morning DTD is so forced my DH used to hate it! But needs must! Ur test date will be around my scan date right, so let's hope the next 12 days go super fast!

Yeah I'm ok thanks, I can't do anything. And I don't want to have hcg bloods and worry and Google them up. Even if they not rising as should there is nothing anyone will do until 6ish weeks and I can have a scan. And now A scan is too early. So I'll just have to be patient and enjoy this heatwave and try keep sane! Have discovered magnum pistachio whoops and yum!

Hula2 · 30/06/2015 19:13

Yep managed another bd this morning at 6 and did the trigger at 8am so think we covered our bases as much as poss and plan to bd wed eve, thurs am and then just have to wait and see. Did an opk before the trigger to make sure not already getting a natural surge and was neg so hopefully can be fairly sure ov will be 36hrs later just as dh get home (poor thing!).

Hope you re feeling ok, you re right you ve just got accept what will be will be and just try and stay positive.

Tryingno1 · 30/06/2015 17:56

Thanks hula-did u trigger and manage to DTD? I have everything crossed for u, u so so deserve ur bFp soon x

Tryingno1 · 30/06/2015 16:47

Ps I don't do a clearblue what will it acheive. I can't have a scan and even I did it would Reassure me for ten minutes! What will be will be. I just need to have some faith and hope it's nothing chromosnolal and the meds are doing their med.

Hula2 · 30/06/2015 16:34

Trying - just hang in there and try to distract yourself. So hard I know but you re pregnant now and not bleeding and nothing else can reliably tell you anything. Def don t do a CB, its not worth the potential stress. Hugs.