Immune /natural killer cell treatment when ttc or pregnant (aka the 16th pred thread!)

Meant only Cheryl was in office for few days. I called healthcare at home myself and paid and got everything set up so all they needed was the prescription to get it to me. So many variables we will never know what makes the difference but I understand wanting to control everything you can. Try not stress though as we all know that can't help. Fingers Xd :)

Lisa- congrats! I was in exactly same position a a had to wait.. Had same emotions & concerns and also older (39). Had intralipids 20 or 22 dpo depending on if ov before SO ovitrelle injection or not (think I did). Anyway wanted to share to try reassure as I'm 22+4 today .. So far, so good. Best wishes.
Waves & hugs to all - been lurking and hoping for more good news. Glad some of the ongoing af challenges are resolving. Xxx

Great news Lisa!fingers crossed we were due some good news on thread! Keep us posted.

Glad everyone af arrived, mine post mc is still awol....

Congrats Lisa
I had intralipids, but I don't need to have them until 6/7 weeks so can't really offer much help. Remember you are on the pred so that will already be working to keep your imunes in check. Fingers crossed for you.

Not sure what to say Dr.... I know I'd kick myself if I did get a bfp and hadn't done the IL if I was in your position. BUT I also understand the not wanting to waste money. Tough one.

Thanks so much guys, will keep you posted, will try not to worry. Didn't mean to sound negative about docs by the way, they've been amazing so far - I think I was just panicked and freaked out - just my luck for it to happen on the one day where Dr S and Louise both not there! X

Congrats Lisa! I also really really hope this is your take home baby!

Sorry to hear you had a tough time arranging treatment. I know it can be so stressful and worrying trying to do everything right for your BFP!

When I got my BFP on treatment I did intralipids very early (3 weeks 3 days!)... It didn't work out for me but now Dr S has suggested I need an extra dose even before BFP. Looks like you're getting them pretty early too though so I wouldn't worry!

Need some opinions- I'm thinking about skipping the pre-ovulation intralipids this cycle. Mainly because I'm anticipating the Pred may have messed things up and it will be a waste of £300... But it's always a gamble isn't it! What do you all reckon? I'd still ttc...

Congratulation lisa, really hope this is the one for you!

Hey
Glad you've all got your AFs ! This cycle messing is a right head fk on top of everything else. It's so ridiculously unfair.
I did just want to pop in with some good news though, I got a BFP on Sunday night!!!!! Had had the week from hell (crashed my car, lots of other crap things happened that I won't go into) so couldn't actually believe it (9dpo). I know I've not been in the chat much but wanted to let you all know (am 43 in a couple of months so there is hope for us who are a little older!!). Am terrified of course and am convinced the worst is going to happen again - it's the oddest feeling.
Gotta say I've been a bit upset as when I contacted Dr S office on Monday Louise was off sick and Dr S is on holiday so was pretty much told to wait until Louise was back in before there was anyone there that could tell me when I'd get my intralipids. I was in tears and freaking out and panicking! I normally miscarry around 5 weeks so was desperate to get them asap and thought more could be done considering my history (and how much it has us cost so far!) Basically the whole thing has been being delayed by 2 days and I'm unlikely to get them til the weekend, am hoping Friday (I'll be 4 weeks pg by thurs/fri). I finally spoke to Louise this afternoon and she did try to put my mind at rest and said as long as I have them at some point in first week it's fine but basically if it all goes wrong again really early on I'm always going to wonder if it was due to this delay.
Anyway, sorry to rant on, I know how lucky I am to be in the bfp position right now, but it's so bloody scary too I can't even put it into words.
if any of you did have the intralipids and you get a spare min please could you let me know how soon after your bfp you got them?!? Am freaking!!

Loki is soooo cute by the way Seeking!!!!!! X

*lp is 12 days! Not love!! Dam iPhone!

Loki is such a cutie. Could easily stay cuddled up with him all day every day. He's being a bit of a terror with the cats but he's only a puppy, they just need to learn to stand their ground!
Yes - I'm ready to try again Drttc. although DH are going through a bit of a drought... If you get what I mean so that's gonna have to be dealt with! Haha!

Glad you're covering all bases. I feel so much more relived knowing that DH are fine chromosomally!

Generally my love is 12 days... I really hope this month was just a blip and it doesn't continue like that!!

Hello everyone!

Snoopy- fingers crossed that was just a one off and cycles will go back to normal now!

Seeking- yay glad you're enjoying puppy life! Do you feel ready to try again?

Trying - Yes I think being pregnant may alter cycle length as well! But when Pred messes it up it feels different... Symptoms at the wrong time of month and not quite feeling right. How are things with you?

Determined- Lovely that you've been able to have a break. Not sure if you said but where is your mum's?

Hula - sorry about the bfn :( It really really sucks seeing that stupid negative test. Sounds like SO does have promising results though...

As for me- AF did end up coming on with a fury! Was glad to have it but boy did I feel awful!! Also, I use clearblue digital to monitor ovulation and I've always made sure to start Pred a few days after I ovulate (to be safe)... So anything that's happened hasn't been due to taking it early.

I've just tried my new beetroot (mixed with lemon juice) supply today and it is SO GROSS! Yuck yuck yuck. Drank it with my nose plugged and my mouth still sensed a deep funkiness in there... Will be drinking it for the next week though :-/ Oh and it looks like you're drinking blood!

Also, I've paid for karyotyping. My results will come within 2 weeks. Hubby takes his test on Sunday so his will be 2 weeks from then. Little by little I'm making sure to leave no stone unturned!

I'm going to try and remain hopeful and believe I just started the pred too early so it delayed ovulation. I didn't really want to do tests on holiday but I guess it's not that big a deal in the grand scheme. Really hope the even longer cycles are not here to stay.

seeking how is little loki? I've heard b vits can extend your luteal phase but not sure which ones/ dosage etc.

trying how are you? Hope you're feeling a bit better

Hey ladies!
Sorry to see so many of you are have issues with your cycle!!
It looks like I'm about to come on ... Only10 or 11dpo I think! Which mean my lip is only 9/10days! Pissed off! Not only is miscarriage heartbreaking it the continues to fuck with your cycles meaning getting pregnant again is an issue! FFS!
Christ know what my cycle will be like with pred next cycle!!

Sorry I've been AWOL! Been busy with puppy. I hope you're all ok(aside from bfns and wonky cycles). Xx

hey guys sorry about ur cycles, how annoying

i always took my pred 2 days after my first positive lh surge so i was sure it was after ovulation and always stopped 10dpo, sometimes 9po when i felt i wasn't preg......i was on it for about 5 months and my cycles were from 25-29...it was told that post MC you cycles can take 4-6 months to sort out....also every time u get preg, ur cycles can permantley change (I've been a 29 day girl for 20 years! then after 1 st miscarriage and NO PRED i was more a 26/27 girl!) ..so don't know if any of you are seeing a change thats just due to the pregnancy rather than pred? either way its a right pain!

maybe delay when you take the red until your sure u ovulated?

hula I'm sure SO will override any red effects as the trigger forces the egg out regardless of anything else....

glad it finally came determined and snoopy.
x

My period arrived last night! Never been so happy to see it haha

Cd46 when I usually have a 33 day cycle

I think the steroids delayed ovulation for me because I got the positive opk as soon as I stopped them and now af exactly two weeks after positive opk.

But now my next af is due right in the middle of our holiday and just in time for my thirtieth how crappy.

hula how many rounds of so have you tried? It must be so hard knowing what to do for the best but I still think you've got such a good chance if you decide to keep going.

SO does sound interesting to me. I know this ha only been one cycle on pred but I've always been paranoid I don't ovulate (although the proof I do is in the three mc )

determined has Dr s suggested any alternatives for you?

Hey Hula, yes I got AF on day 53 which has never happened before. I believe it's because I took it before OV and for 14 days. Louise said they used to give it to women for 14 days before but it messed their cycles up to much. The last time I had a wonky cycle that wasn't an mc was when I think I took it too close before OV and I hadn't actually ovd yet. After which I always left it 2 days and was always ok. My last cycles lp was only 4 days (took 49 days to OV!) so I am grateful of a little extension by a few days!

I tried reflex, acu, high vit c, everything but as I hadn't ovd nothing really worked until then :(

It's so pants you guys cycles have gone wonky, it just feels like another thing to bloody manage on top of it all. I just keep myself busy and eventually my body did what it needed to but I did have a couple meltdowns! I'm cd 13 and prob still a week away from Ov still looks like it is so again for me next cycle! Gulp!!!

Hula-I don't remember my cycles being messed up when I did so I think there drugs were powerful and overrides it. My prob is sluggish Ov really, once that happens am generally ok.

Snoopy Do you have any cyclogest? Dr S said you can use that to induce a bleed if it goes too long...(I held off in the end) so couldn't tell you how long to do it for but maybe worth asking!!

Am away at mums and it's so hot! So needed the break as been super busy lately waves to all xx

Sorry Dr this is happening to you too. I get what you re saying Snoopy, its a comfort to know its not just your body playing up and i felt the same.

Re SO i ve only done two cycles and since i had this prob with pred and had recently had four doses of humira the plan was to wait on bfp for pred but normally u do it from ov, which obviously is very accuratley pinpointed because of the scan. I think Rosa and Sunny where fine on pred from ov when doing SO. I don t know if the SO drugs would help override things, i m really in two minds whether to try pred again for my next SO cycle as it did seem to take about three cycles for me to get back to normal but if immune issues are stopping me even get preg then if i don t take pred will i ever get preg, so hard to know !

I hope everyones af start behaving, mines due tomorrow, Determined is yours back yet ?

Thanks everyone.

It's so upsetting to see that so many of us are struggling with the same issue but ( I hope this doesn't come across the wrong way because I pains me that any of us have to suffer this) it does comfort me to know I'm not alone and you're always here for me.

hula when you're doing the SO do you take pred from ovulation or bfp?

Just saw your post snoopy and wanted to say I'm in a similar position!

AF was due yesterday and for the first time ever instead of a full period I've only have some very light spotting/bleeding. Don't even need anything in! Before Pred I was like clockwork for 17 years. AF on CD26 in the same predictable flow pattern. Now, I have NO idea what's going on this cycle and like you it's upsetting. It makes me question if this actually is treatment that is ever going to work for me :-/ If it stops my cycles/ovulation then how can I get pregnant?!

Oh Snoopy i m sorry, how frustrating. Acu can be good at bringing on af or maybe ring Louise and see what she suggests.

Many people have sucess just taking from bfp (seems like only dr s uses from ov, unless you re doing ivf) and some places seem to use intralipids pre ov instead. Quite a few of us are in the same boat with steriods messing cycles. I don t know if SO can override the effects as haven t tried steriods with my two SO cycles for same reason but might try again next time if i dare.

Hope af shows up soon.

Bad day today. No period, no anything after 46 days. How have steroids messed everything up so badly in one cycle. Where do I go from here?

Thanks Trying. Gosh 10 rounds of ivf, goes to show how determined people can be. We can only try our best and ultimately what will be will be...

Better get some sleep. Night x

It's a tough one, to know when to stop.... For now keep on ur SO, and I really really really hope it works out soon for u. And this is just hypothetical talk! U have been waiting long enough. Xxx
A woman on the ivf thread got her bFp on ivf number 10!!!

Yeah i know, i was actually glad not to be preg today with all the stress it caused.

I have wondered if we should consider it and we were about for ds when i fell preg. I think i could prob manage the actual process but the 90% chance of failure now would be what i d struggled with and dh was a def no last time we discussed it.